Talk:Granulin

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Wpongster8.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:37, 16 January 2022 (UTC)

The Progranulin Project
Hi!

The goal of this project is to present an updated review on progranulin's role in both healthy and diseased individuals. I plan on reorganizing the entire page to fit this goal while maintaining the information that is already present on this page. The primary focus of the page will be on circulating theories on progranulin function. I am wondering what the community thinks about the proposed outline. All feedback (especially constructive criticism) is welcome!

Introduction

Structure

1) Genetic

2) Protein

Expression

1) Expression Levels Across Cell Types

2) Post-Translational Modifications

3) Epigenetic

The Difference Between Progranulin and Granulin

Function

1) Trophic Factor in Development  a. Neurite Outgrowth

2) Synaptic Pruning

3) Wound Healing

4) Inflammatory Response  a. Peripheral Cells   b. Central Nervous System

5) Cell Proliferation

6) Signaling Pathways  a. SORT1

7) Maintaining Protein Homeostasis  a. Lysosome

Disease

1) FTLD

2) Cancer

3) Metabolic Disease

4) Neuronal Ceroid Lipofuscinosis

Current Areas of Research

Current Models

1) Mice

2) In Vitro — Preceding unsigned comment added by Wpongster8 (talk • contribs) 07:28, 10 May 2018 (UTC)