Talk:Growth cone

Wnt does act as a guidance cue, not sure about Shh. Probably though - most things that set up gradients determining cell fates also act as guidance cues. Specifically wnt guides Retinal Ganglion Cell axons pathfinding to the optic tectum. CWB —Preceding unsigned comment added by 188.223.85.80 (talk) 21:01, 31 July 2010 (UTC)

I
I noticed something bizzare, there is a line in the page that reads " It has more recently been shown that cell fate determinants such as wnt and sonic hedgehog(shh) can also act as guidance cues."

I don't think that is correct, can someone who is more experience on this topic than I, please fix it


 * Basic vandalism. WhatamIdoing (talk) 05:04, 19 June 2008 (UTC)

Expanding the Article
Hi, I'm going to be editing this page. I plan to just expand all the categories and supply more detailed information in each one. I also plan on adding another category about axon and branch growth in addition to the category on axon guidance. The images that I will be adding are my own, and I am willing to make any changes to the images if anyone has suggestions. I will make these changes soon, and they will probably be made in just one or two additions. Chris1387 (talk) 19:04, 4 April 2008 (UTC)

I think it is true that shh at least can act as a repulsive cue in the optic chiasm. I'm not perfectly sure how this works, but isn't the target of Shh-Signaling (Ci/Gli) bound to microtubili by factors that are phosphorylated during Shh-Signaling? I hope someone knows better than me... Clbl134 —Preceding unsigned comment added by 132.230.21.52 (talk) 16:50, 16 April 2008 (UTC)

Reticulon 4, or Nogo
Someone with the knowledge of the subject might add a proper clause telling that this protein inhibits axonal growth. -- C opper K ettle  15:33, 12 January 2009 (UTC)
 * There are literally hundreds of genes/proteins that activate or inhibit axonal growth: that's how axonal guidance works.  Mentioning individual ones without some sort of overview would be very misleading.  Unfortunately, I don't know enough about this area to write such a thing. Looie496 (talk) 18:14, 12 January 2009 (UTC)

"Axon guidance" image
This image is needlessly confusing, since it reverse the colour coding for actin and microtubules that's followed in the first image. (The colouring in the second image is not clear). The usual textbook standard is actin in red and MTs in green. 67.230.143.151 (talk) 14:57, 23 April 2013 (UTC)
 * I agree, but it's very difficult to find good images that are licensed in a way that makes them usable for Wikipedia. It would of course be possible to reverse the colors using an image editing program, but I'm not sure that would be a legitimate thing to do. Looie496 (talk) 16:29, 23 April 2013 (UTC)
 * It's perfectly legitimate for the last image, which permits derivative works under the license. 67.230.143.151 (talk) 12:23, 25 April 2013 (UTC)
 * There's no doubt that it is legal to change it. The question is whether it is moral -- manipulation of scientific images must be handled very carefully.  My opinion is that it is okay here if the caption clearly states that the colors have been reversed from the original to make the color scheme match the earlier image. Looie496 (talk) 16:41, 25 April 2013 (UTC)
 * I'm only suggesting changing the hand-made image, not fiddling with the microscope data. I don't see an ethical issue there, particularly since the sole point of the image is pedagogic. 67.230.143.151 (talk) 23:42, 26 April 2013 (UTC)