Talk:Guaiacol

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Is Guaiacum resin a name for Guaiacol?
Being bold, I have tentatively wikilinked Guaiacum resin as Guaiacol in the Guaiacum page because they seem to be the same ... but a subject matter expert should know better. If so, maybe said person could add the resin name in the top and as a redirect? --Eliyahu S Talk 06:47, 29 January 2010 (UTC)

Plant resins such as Guaiacum resin are typically mixtures of several distinct chemical substances, often terpenes. Guaiacol is a particular non-terpene substance (C7H8O2), so I think it is different from guaiacum resin, and may not even be a component of the resin. The similar name may come from its being a decomposition product from heating the resin. The resin itself seems to contain, among other things, the sesquiterpene alcohol guaiol (C15H26O), but I have not been able to find a good reference for the resin and what it contains, nor its relation to the guaiac used in the diagnostic stool guaiac test.CharlesHBennett (talk) 05:47, 18 February 2010 (UTC)

Naturally Occurring?
How is Guaiacol naturally occurring if it occurs as a residue from Pyrolysis incineration that requires a temperature above 430 °C (800 °F) when most fires are in the 200°C - 300°C range? Secondly, if it requires the absence of oxygen which does not occur in Nature, how again is that "naturally occurring"?

It is a natural product of pyrolysis of lignands. creasote and fractioning through distillation to pharmacologically useful products. [see sanskrit at bottom of page] Sanskrit sources undoubtably contain references to oil of creasote and its main three fractions. I am beginning to wonder if any of the German and Japanese patents are valid in light of Ayurveda and Traditional Chinese Medicine. I am not fluent in Sanskrit or German, though I am thankful to both traditions. Ayurvedic medicine is the oldest, much of the most ancient sanskrit texts do appear to be preserved in Chinese. Further study of Sanskrit and Chinese will probably give us a better idea of who discovered the pyrolignans and catecholamines, not Von Brohn Van Huesen, or that japanese guy it was probably Charaka or Vibhava.

Stevenmitchell (talk) 19:04, 12 August 2010 (UTC)
 * There is no reason to think that two possible origins are mutually exclusive.  Some organisms can biosynthesize guaiacol, so it is accurate to say that it is a natural chemical compound. Here is a reference for one example where it is found to be made by an insect: Duffey, S. S.; Aldrich, J. R.; Blum, M. S.  Biosynthesis of phenol and guaiacol by the hemipteran Leptoglossus phyllopus.    Comparative Biochemistry and Physiology, Part B:  Biochemistry & Molecular Biology  (1977),  56(2B),  101-2.  Separately, guaiacol can also be formed artificially by pyrolysis of lignan.  -- Ed (Edgar181) 19:13, 12 August 2010 (UTC)

Sirolin
It may be quite bizarre and tangential, but on page 138 of one of Roche's [www.roche.com/rochea_z.pdf self-publicity pamphlet] there is a late 19th century ad for Sirolin antiseptic, whose active ingredient is guaiacol, or more specifically a saint card provided by Roche syrup. Given its age, it cannot be copyrighted and I found it quite intriguing. I admit that a photogram of a olde bottle of the syrupe itself would be better, but that would be near impossible to get. --Squidonius (talk) 23:07, 28 January 2012 (UTC)

Sanskrit texts predate sited sources
क्रव्यप- तैल - Oil of creosote [Pharm] (guaicol, catechol, sryngol; known fractions); "Smoke Flavor" क्रव्यप       - Creasote, pyrolignands (related) क्रव्यप- प्राङ्गारीय - Creasote Carbonate [Pharm] (related)

Ayurvedic use of creasote predates the 1800s. Check Indian Materia Medica. — Preceding unsigned comment added by 207.118.95.141 (talk) 07:27, 9 June 2015 (UTC)

unsourced
moved the content below here per WP:PRESERVE. Per WP:BURDEN please don't restore without finding reliable sources, checking this content against them, and citing them.

Guaiacol carbonate is known as duotal, the phosphate as phosphatol, the phosphite as guaiaco-phosphal (phosphotal is a mixture of the phosphites of creosote phenols). The valerianic ester of guaiacol is known as geosote, the benzoic as benzosol, the salicylic as guaiacolsalol, while the glycerin ether is the drug guaifenesin. The related derivative, dimethoxybenzene or veratrole, is also useful. In preparation of food by smoking, guaiacol is the main chemical responsible for the smoky taste, whereas syringol is responsible for the smoky aroma. Eugenol is guaiacol with a vinyl substituent on the 4-position.
 * Related compounds

In basic solution, it is readily oxidized, giving yellowish brown and absorbs light maximally at about 470 nm.
 * (from uses section)

Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic.

--Jytdog (talk) 02:19, 1 May 2017 (UTC)

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CAS report
Guaiacol has been mentioned or discussed in 18,501 reports according to Chemical Abstracts as of today.--Smokefoot (talk) 12:14, 19 November 2019 (UTC)

Names section
One of the names on here seems wrong. The last one, "2-methoxyl-4-vinylphenol." morsontologica (talk) 13:32, 13 December 2019 (UTC)

Petrochemical
If guaiacol is described as a petrochemical or petrochemical precursor, why is the term "petrochemical" mentioned nowhere in the current version of this article? 173.88.246.138 (talk) 05:55, 23 July 2021 (UTC)