Talk:Hemostasis

Redudant paragraph
Two of the paragraphs of the current edition of the article read as follows:

"Platelet plug formation - Platelets adhere to damaged endothelium to form platelet plug (primary hemostasis) and then degranulate. Platelet Plug Formation: Platelets play one of the biggest factors in the hemostatic process. Being the second step in the sequence they stick together (aggregation) to form a plug that temporarily seals the break in the vessel wall. As platelets adhere to the collagen fibers of a wound they become spiked and much stickier. They then release chemical messengers such as adenosine diphosphate (ADP), serotonin and thromboxane A2. These chemicals are released to cause more platelets to stick to the area and release their contents and enhance vascular spasms. As more chemicals are released more platelets stick and release their chemicals; creating a platelet plug and continuing the process in a positive feedback loop. Platelets alone are responsible for stopping the bleeding of unnoticed wear and tear of our skin on a daily basis.[3]

''The second stage of Hemostasis involves platelets that move throughout the blood. When the platelets find an exposed area or an injury, they begin to form what is called a platelet plug. The platelet plug formation is activated by a glycoprotein called the Von Willebrand factor (VWF), which are found in the body’s blood plasma. When the platelets in the blood are activated, they then become very sticky so allowing them to stick to other platelets and adhere to the injured area."''

Notice how the first paragraph already includes the "second step of the sequence" without making it explicit it is secondary hemostasis and explains the platelet plug formation. The following paragraph then describes the same thing, even saying that it begins to form what is called a platelet plug, when this term had already been introduced in the previous paragraph! It also mentions that platelets become more sticky, which was already covered previously as well. The only useful thing this paragraph introduces is the VWF. I suggest for the VWF part to be inserted in the first paragraph and the second paragraph to be erased entirely. --Ericobnn (talk) 15:29, 19 September 2012 (UTC)

Student comments
I particularly enjoyed how you chose to arrange the article. It has a very logical, clear flow to it. I wonder it you have too much detail in the introduction at the top of the page though? Perhaps that material should be included elsewhere. Just FYI as well, I'm not sure why, since I see your in text citations and end references, but wiki has this tagged as not having references. KaitVW312 (talk) 15:13, 26 April 2012 (UTC)
 * The mechanism and steps section areessentially duplitious. They should be merged. Don't have time to do the merger, but I'm going to make sure the steps are numbered sequentially. 129.180.166.53 (talk) 06:30, 10 June 2012 (UTC)
 * Yes check.svg Done OK, I've done this myself. But we should look at why hemostasis and coag is different. Coag is a lot better quality of an article. 129.180.166.53 (talk) 06:51, 10 June 2012 (UTC)

Homeostasis
Could somebody add "not to be confused with homeostasis", these are very different concepts but very similar words! —Preceding unsigned comment added by 194.72.81.141 (talk) 15:43, 5 June 2009 (UTC)

I
I have no medical training, but I'm researching Hemostasis and Hemostatic Products as part of a larger project. It seems like this article could be expanded, just based on the basic research I've done so far. Again, I have no expertise to expand it myself...

Thanks! Katiewray 16:38, 3 July 2007 (UTC)

Instead, one could merge it with Coagulation. --Dietzel65 (talk) 21:49, 19 November 2007 (UTC)

this link: http://www.hemostasisllc.com/ is inappropriate

Should be expanded. Might help if someone added links to "platelet plug formation", "coagulation" and "fibrinolysis" (don't know how to do it myself), but the article still should be expanded. More info about cellular and blood-derived mediators would be nice.

André Flakk —Preceding unsigned comment added by 194.54.110.98 (talk) 21:01, 24 April 2008 (UTC)

Broad definition
Note: This was initially posted on the article page by Dceferguson, so I moved it to the discussion page.

Currently, more and more in discussions relating to health status and fitness, particularly in relation to geriatric ftiness, health promotion, and in relation to exercise, hemostasis is increasingly used as a term to refer to health benefits of promoting hemostasis over and beyond assisting coagulation processes. One is reminded of the use of the term homeostasis which extends beyond the simple concept of balancing sympathetic and parasympathetic nervous systems to broader notions of balancing bodily systems beyond them. Given what is known about exercise and prevention of cognitive decline it seems likely that hemostatic processes go far beyond coagulation and such benefits are likely mediated by as yet not clearly defined changes in hemostatis. Both muscles AND brain benefit by physical activity, both are mediated by improved blood supply and waste removal, and both are mediated by vascular patency and biochemically healthy changes within the blood itself beyond simple coagulation action. I would argue the concept of hemostasis needs broadening in the same way that homeostasis now covers a variety of component processes beyond the simple ones.

Coagulation and related terms are quite adequate to describe what these activities do. They are not in need of synonyms, however hemostasis as a concept which is increasingly being used to describe processes and functions which go beyond coagulatory housekeeping affords the opportunity to enlarge a term to a wider health related set of component functions. Please note I intentionally have not specified specific particular additions, but hope to stimulate thought and debate as to what might be usefully added to the conceptual breadth of an increasingly utilized term.

As a retired Professor of Preventive Medicine I recognize the need for additional ways to speak about and define health and wellness functions and processes. This concept presents a golden opportunity to enrich our technical conceptual language. We already have narrow operational definitions for most individual physiological functions, but have a limited repertoire of higher order concepts and terms that embrace multiple health related processes. What does the Wikipedia community think, and what can be meaningfully and usefully subsumed under Hemostasis as a broader term so as to give it the more useful breadth it seems to cry out to embrace? Necessity is said to be the mother of invention. We know rather well what illness is, but simly try to define health as I have asked my physician MPH candidates to do as term papers and you will find yourself in deep conceptual water very quickly.

Cmcnicoll (talk) 15:52, 10 February 2009 (UTC)

You should probably add the websites into the citing section so that viewers can look at your sources. The three different mechanisms by which homeostasis is maintained could be made into their own section, instead of in the Overview section.

(Bleonard4 (talk) 03:01, 22 April 2012 (UTC))

Anatomy Class
I thought it was a very good start but I feel that in the overview it seems that what was already on the page was just reworded. In the beginning of the page you talk about how when Greece took over Egypt they made medical advances, what were these advances? The only other thing I saw was some of the wording could be redone. Str7 (talk) 01:55, 25 April 2012 (UTC)

I was curious about the history of hemostasis: these are techniques in hemostasis but isn't hemostasis a natural process as well? I feel like that section should be the history of artificial hemostasis. Morgandalis (talk) 11:30, 25 April 2012 (UTC)

I thought this was a well constructed article with a lot of great information. There is some repetition within the article itself, and just be careful of using filler words that make your sentences unnecessarily long. The only suggestion I might make is perhaps combining the mechanism section with the steps section since they both tire in with one another. Also there are some important words through out this stub that you might want to try and link to other wikipedia articles. Other than these few minor changes I think you all did a great job on this. The pictures are a great touch. (Dgklp18 (talk) —Preceding undated comment added 20:00, 25 April 2012 (UTC).

Very well organized. It was interesting to learn the steps of hemostasis as well as the mechanisms and different types of hemostasis. The article was well organized with alot of information. I do feel that there are many stubs in this article however that do not need to be there. Other than that great work. "Mikechuchla (talk) 23:54, 25 April 2012 (UTC)"

I'm very impressed. This Wikipedia article was informative, concise, and easy to understand. It was laid out very nicely, and was well organized (although I'm confused as to why the "overview" section isn't included with the intro at the top of the page). Caroline E Jones (talk) 10:37, 25 April 2012 (UTC)

Good article nomination
As it might look strange that I failed this article with out a tag having existed, I did so based on this manual inclusion on the list. --LauraHale (talk) 02:46, 29 April 2012 (UTC)

The article is interesting but it contains grammatical errors and is written in a casual—rather than technical—style in parts. 66.26.95.207 (talk) 20:48, 27 May 2012 (UTC)

Uncited material
I've removed all the uncited material from the article. This is a major first step towards working towards WP:GAN. The information should be replaced with new text and citations as it now leaves rather gaping holes in the article. :( When adding the information, please try to use prose instead of lists. If you're inclined to use lists anyway, consider using tables instead as a better visualization tool.--LauraHale (talk) 03:00, 29 April 2012 (UTC)

Citation review
The article uses only ten sources. I've looked at other medical good articles and they used way more than ten. For example, HIV has 210. Herpes simplex has 100. Poliovirus has 49. Consciousness has 122. Malpuech facial clefting syndrome has 26. Prion has 85. Homeopathy has 225. Hypertension has 110. Hypopituitarism has 28. Kidney stone has 71. The following is the complete list of sources used in this article:


 * Marieb, Elaine Nicpon, and Katja Hoehn. Human Anatomy & Physiology. 8th ed. San Francisco: Benjamin Cummings, 2010. 649-50.
 * Wies, C. H. "The History of Hemostasis." Yale Journal of Biology and Medicine 2 (1929): 167-68. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606227/
 * Boon, G. D. "An Overview of Hemostasis." Toxicologic Pathology 21.2 (1993): 170-79.
 * Clemetson, Kenneth J. "Platelets And Primary Haemostasis." Thrombosis Research 129.3 (2012): 220-224 http://www.sciencedirect.com/science/article/pii/S0049384811006323
 * Kulkarni, Roshni. "Alternative and Topical Approaches to Treating the Massicely Bleeding Patient." Ed. Craig M. Kessler. Advances in Hematology 2.7 (2004): 428-31. Clinical Advances. Current Development in the Management of Hematologic Disorders http://www.clinicaladvances.com/article_pdfs/ho-article-200407-hem.pdf
 * Aldo Moraci, et al. "The Use Of Local Agents: Bone Wax, Gelatin, Collagen, Oxidized Cellulose." European Spine Journal 13.(2004): S89-S96.
 * Smith, Shondra L., John M. Belmont, and J. Michael Casparian. "Analysis Of Pressure Achieved By Various Materials Used For Pressure Dressings." Dermatologic Surgery 25.12 (1999): 931-934.
 * Orhan Kozak, et al. "A New Method For Hepatic Resection And Hemostasis: Absorbable Plaque And Suture." Eurasian Journal Of Medicine 41.(2010): 1-4. Academic Search Complete.
 * Mohammadreza Tahriri, et al. "Preparation And Characterization Of Absorbable Hemostat Crosslinked Gelatin Sponges For Surgical Applications." Current Applied Physics 11.3 (2011): 457-461.
 * Tocantins, Leandro M., William O. Reid, Melvin J. Silver, and Louis A. Kazal. "Current Problems In Hemostasis." Annals of the New York Academy of Sciences 115.2 Computers in (1964): 21-30 http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1964.tb41028.x/abstract

The total is ten. Can another 20 sources that pass WP:MEDRS that are not reliant on the same author or book (but with different page numbers) be identified for use in this article as sources to expand it? --LauraHale (talk) 05:22, 29 April 2012 (UTC)

Hemophilia does not result from insufficient clotting.
I am surprised that none of the previous readers picked this up. Hemophilia is a cause, not a result!


 * Depends. The clinical syndrome of haemophilia is the result of disordered coagulation. This in turn results from coagulation factor deficiencies. JFW &#124; T@lk  17:44, 19 November 2014 (UTC)

MicroRNAs
Play a role. 10.1111/jth.12788 JFW &#124; T@lk  17:44, 19 November 2014 (UTC)

Digestivesystem 103.121.173.17 (talk) 12:38, 15 January 2024 (UTC)