Talk:Heparin-induced thrombocytopenia

Synchronize with Thrombocytopenia
''cross posted Thrombocytopenia should be synchronized with Heparin-induced thrombocytopenia, and summarize it. Could an expert do this please? --Hroðulf (or Hrothulf) (Talk) 09:12, 22 May 2008 (UTC)

Spontaneous form
Four patients with spontaneous HIT:. Primary research but possibly worth mentioning. JFW | T@lk  12:16, 26 June 2008 (UTC)

ACCP
ACCP guideline JFW |  T@lk  01:14, 3 October 2008 (UTC)

Rewriting
I don't usually do this, but today I had to refactor some content that was standing in the way: here. Much of the content was unsourced despite making numerical claims, and most of the sources were primary sources. Finally, much of the content was highly technical. I will be populating sections per WP:MEDMOS in due course. Please bear with me. JFW | T@lk  22:16, 25 November 2008 (UTC)

Beware of antiphospholipids
JFW | T@lk  23:24, 23 July 2009 (UTC)

NEJM 2006
I had completely overlooked:



Let's see if I can get hold of it. JFW | T@lk  12:57, 9 August 2009 (UTC)

Treatment
As usual this article has been lying fallow because I was too chicken to write a good "treatment" section. I think we need to cover all three licensed anticoagulants, their monitoring and drawbacks. Perhaps a bit about the troubles about setting the target for lepirudin. JFW | T@lk  23:18, 8 September 2009 (UTC)

Could use some images of this condition
Similar to or   Doc James  (talk · contribs · email) 08:47, 15 December 2009 (UTC)


 * Haven't seen any. Have you got a few? JFW | T@lk  20:09, 15 December 2009 (UTC)


 * No it is no very common. Will keep my eyes open a get a picture when possible.  That uptodate article I sent you expands a bit of epidemiology.  As we switch over to LMWH HIT will be less common. Doc James  (talk · contribs · email) 20:14, 15 December 2009 (UTC)


 * Warkentin is a bit more cautious about LMWH being less HIT-ogenic. The last case I treated was due to dalteparin. JFW | T@lk  23:38, 22 December 2009 (UTC)

Heparin IS natural, and found in the human body
I saw that the article mentioned that heparin is not naturally occurring, but that is obviously false. I cited my edit. I'm not a Wikipedia person, hope I did it right. 68.46.171.223 (talk) —Preceding undated comment added 00:11, 22 February 2010 (UTC).


 * The problem is that your edit introduced a non-sequitur. Pharmacological heparin is clearly immunogenic and your edit doesn't explain that. Please revise your contribution. JFW | T@lk  19:58, 22 February 2010 (UTC)

RIETE
A very large data set (RIETE) shows UFH indeed carries a higher risk than LMWH. 10.1111/j.1538-7836.2011.04402.x JFW &#124; T@lk  07:49, 21 September 2011 (UTC)


 * The report does not seem to discuss confirmation of the diagnosis with anti-PF4 or serotonin release assays. JFW &#124; T@lk  07:52, 21 September 2011 (UTC)

Paper to follow up
10.1111/j.1538-7836.2011.04536.x is an ISTH working group report on standards in HITT diagnosis. Accepted for publication, but still a bit raw to be cited. JFW &#124; T@lk  22:37, 18 October 2011 (UTC)


 * 10.1111/bjh.12059 is the new version of the British guidelines. May need to review those and update the article. JFW &#124; T@lk  21:42, 15 October 2012 (UTC)


 * 10.1111/jth.12153 is a systematic review on HIT in children. Again pre-publication, but seems MEDRS and needs following up/incorporation. JFW &#124; T@lk  16:49, 30 January 2013 (UTC)


 * 10.1056/NEJMct1206642 NEJM review on treatment. JFW &#124; T@lk  07:08, 21 February 2013 (UTC)

New NEJM review
FYI, a new review in NEJM is out, with some good info such as the use of fondaparinux for treatment; probably a good time to update the treatment section anyways, now that Lepirudin is off the market. Yobol (talk) 01:26, 22 April 2013 (UTC)


 * I wish I had time for it. Perhaps in a little while I can update the article and get it to FA at the same time. JFW &#124; T@lk  21:04, 29 April 2013 (UTC)

Criteria
Recommendations for standardization of laboratory testing for drug-induced immune thrombocytopenia: communication from the SSC of the ISTH 10.1111/jth.12852 JFW &#124; T@lk  21:27, 25 January 2015 (UTC)

NEJM
Greinacher review: 10.1056/NEJMcp1411910 JFW &#124; T@lk  08:05, 16 July 2015 (UTC)

Immunology
Heparin-protamine antibodies 10.1111/jth.13405 JFW &#124; T@lk  07:03, 7 July 2016 (UTC)

JTH review
10.1111/jth.13813 JFW &#124; T@lk  11:59, 7 November 2017 (UTC)

Treatment
Systematic review 10.1182/bloodadvances.2020002963 JFW &#124; T@lk  11:28, 15 April 2021 (UTC)