Talk:Hepatitis E/GA1

GA Review
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Reviewer: Casliber (talk · contribs) 20:29, 14 August 2019 (UTC)

I'll take a look. I will make straightforward changes as I go and jot queries below. Please revert if I accidentally change the meaning. Cas Liber (talk · contribs) 20:29, 14 August 2019 (UTC)
 * Cas Liber thank you--Ozzie10aaaa (talk) 20:50, 14 August 2019 (UTC)


 * I'd link incubation period, zoonosis, capsid.
 * ✅ incubation period, capsid while 'zoonosis' was already linked via 'zoonoses' (alternate spelling)


 * Convert centigrade to fahrenheit
 * ✅ and  placed in parenthesis


 *  After a short prodromal phase symptoms lasting from days to weeks follow.  - are there any symptoms in the prodromal phase? Also, "days to weeks" is a bit vague/noninformative for the reader
 * ✅ agree have clarified the text in question per......an initial phase of mild fever, reduced appetite, nausea and vomiting


 * How long do/can chronic infections last?
 * per review.......chronic Hepatitis E can be diagnosed at 3 months however as to how long chronic Hepatitis E can last (according to this review) is not as obvious, "A few liver-transplant patients with chronic HEV infection were given a 3-month (n = 3) or a 12-month (n = 1) course of pegylated interferon (135 μg/week) ", according to the author within the first year chronic Hepatitis E can cause complications. I therefore have inserted  the time to diagnosis of the chronic condition.Should you wish me to elaborate on how long the chronic condition can last (and almost invariably its potential for complications) then I will do so
 * Adding the 3 month diagnosis is good Cas Liber (talk · contribs) 14:31, 17 August 2019 (UTC)


 *  For some of these reported conditions the relationship is tenuous, but for several neurological and blood conditions the relationship appears causal - do you mean the ones listed below? Or is this all and only some are causal?
 * ✅ agree have added per...... "According to the available data, HEV infection appears to be strongly associated with acute pancreatitis, neurological disorders (with primarily dominant peripheral nerve involvement, most commonly manifested as Guillain-Barré syndrome, followed by neuralgic amyotrophy), hematological diseases (hemolytic anemia due to glucose phosphate dehydrogenase deficiency, and severe thrombocytopenia), glomerulonephritis, and mixed cryoglobulinemia. More data are needed to clarify whether an association exists with musculoskeletal or other immune-mediated manifestations"


 *  As mentioned, the incubation period following exposure to the hepatitis E virus ranges from 3 to 8 weeks, with a mean of 40 days - you've already mentioned this, in fact teh mean should be at the top mention. I'd say something like, "The length of the incubation period means that/leads to..." or something
 * ✅ agree have added


 * The article has two different cooking temperatures and times...and one is more confident than the other...
 * ✅ agree have added
 * Err, there is still the discrepancy....Cas Liber (talk · contribs) 14:33, 17 August 2019 (UTC)
 * per ... "suggested that 71oC for 20 minutes was needed to kill the virus completely. Other studies in various food matrices including pig liver, suggest that 71oC for 10 minutes or even 70oC for 5 minutes would be sufficient to kill the hepatitis E virus"...the source indicated different times for different temperatures
 * Problem is, then, the two different values in two different parts of the article just looks like two inconsistent parts of article. Would be best in same place of article somehow Cas Liber (talk · contribs) 12:57, 20 August 2019 (UTC)
 * a solution could be to incorporate the text the source indicated different times for different temperatures (which it does)
 * Yeah just something that explains the (apparent) discrepancy Cas Liber (talk · contribs) 00:35, 21 August 2019 (UTC)
 * ✅ have added


 * Has the chinese vaccine been used outside China?
 * per Chinese-HEV vaccine, clinical trials in the United States have started, however there has been no approval/license


 * Also, if the Ugandan outbreak was the largest, it probably should be expanded a bit to give proper weighting. Also, was the vaccine used in any of these outbreaks?
 * ✅ agree have added
 * was unable to find periods of use of HEV vaccine, furthermore per WHO... the	absence of sufficient information at this time,WHO does not make a recommendation on the introduction of the vaccine for routine use in national programmes...where HEV is common


 *  Outbreaks of epidemic hepatitis E most commonly occur after heavy rainfalls and monsoons because of their disruption of water supplies - probably better to explain this a little more - i.e. contamination of drinking water with effluent (I guess). Cas Liber (talk · contribs) 22:29, 17 August 2019 (UTC)
 * ✅ agree have added with reference


 * What is the rationale behind the para splits in Recent outbreaks section? The first one is the largest outbreak...but then you have an African and Asian one in the next para...aaand an African one in the last.
 * the events are set by order in which they occurred, first being 2007 to the most recent 2019should you feel the 'para splits' should be different I would change then to your suggestion (however as indicated in the answer below this one, the outbreak in Namibia has been updated, and therefore has more text)
 * Nothing else is jumping out at me as a better way to do it. Cas Liber (talk · contribs) 20:53, 20 August 2019 (UTC)


 *  An outbreak was reported in Namibia in southern Africa, in January 2018, the total infected is reported as 490 - is written like it was just added...and left. Needs to be reworded to fit with the next two sentences.
 * ✅ have reworded and updated per...


 * This [https://academic.oup.com/cid/article/42/12/1685/294418 2004 outbreak0 in South Sudan was interesting as they discuss the water supply.
 * ✅ have added with reference


 * I just came across this article, which should be included - other salient facts - historically we used to call other viral hepatitises non-A non-B hepatitis. It also cites this paper, which seems to be about the discovery of the virus.

So yeah, finding out who called it Hep E and when and adding would be good....
 * ✅ have added per


 * The Webb article also states that Hep E is the most common cause of viral hepatitis worldwide. That should be included prominently if true.
 * Hep E is the most common cause of viral hepatitis worldwide.(per above)....however per the WHO Every year, there are an estimated 20 million HEV infections worldwide, leading to an estimated 3.3 million symptomatic cases of hepatitis E ....while WHO estimates that in 2015, 257 million people were living with chronic hepatitis B infection (defined as hepatitis B surface antigen positive)...this table from ..., is also noteworthy


 * WHO estimated that in 2016, approximately 399 000 people died from hepatitis C, while Hepatitis E caused approximately 44 000 deaths in 2015
 * The comparisons would be good to put in Viral hepatitis. Good to get some perspective on that...Cas Liber (talk · contribs) 23:00, 20 August 2019 (UTC)


 * The Webb article also states in epidemiology "Young adults are most commonly affected, especially the 15–35 age group, and men are more likely to be infected than women" - not mentioned in this article.
 * ✅ have added


 * The Webb article also mentions renal complications
 * the article already states under 'Signs and symptoms' in the 'Other organs' subsection.... Glomerulonephritis with nephrotic syndrome per
 * Aaah missed that. was CNTRL-F looking for "renal" and "kidney" Cas Liber (talk · contribs) 23:03, 20 August 2019 (UTC)


 * The Webb article also has a table "Who should we test for HEV?" - article lacks information on indications for testing..
 * article has a 'Diagnosis ' section which contains subsection 'Virological markers'
 * Yes but the newer article has some discussion on when to test. Cas Liber (talk · contribs) 23:03, 20 August 2019 (UTC)
 * ✅ have added with reference


 * The Webb article gives 2-8 weeks as incubation period (vs article's 3-8 weeks. I'd take a review article over a fact sheet but might be good to figure out why there is a discrepancy and think of a rationale to go with one or the other.
 * ✅ have added however have used a different source...


 * The Webb article also discusses unanswered questions/dilemmas - I think this is fascinating and illustrates science as a work-in-progress and highlights the challenges i.e. the knowledge is by no means set in stone.
 * yes they are interesting questions, how should we proceed...--Ozzie10aaaa (talk) 23:53, 20 August 2019 (UTC)
 * The article has them in point form, but I am thinking that prose is better. I'll have a look and think....Cas Liber (talk · contribs) 00:35, 21 August 2019 (UTC)


 * Ok, looking at the questions - they can be sprinkled into prose (I guess) next to the relevant discussions, such as "Other animal reservoirs are possible but unknown", "The mechanism of neurological damage is unknown". , "The mechanism of/reason for its severity in pregnancy is unknown".  Cas Liber (talk · contribs) 08:40, 21 August 2019 (UTC)
 * I'll add the 3 you've indicated above, however as for the remaining 8 questions, inserting too much text that indicates 'unknown' might have a negative effect on how the article is viewed by readers...IMO--Ozzie10aaaa (talk) 09:05, 21 August 2019 (UTC)
 * Yeah - I agree that some are not really encyclopedic and after looking at them was thinking exactly the same thing (i.e. using a select few) Cas Liber (talk · contribs) 09:28, 21 August 2019 (UTC)
 * ✅ have added--Ozzie10aaaa (talk) 14:40, 21 August 2019 (UTC)

1. Well written?:
 * Prose quality:
 * Manual of Style compliance:

2. Factually accurate and verifiable?:
 * References to sources:
 * Citations to reliable sources, where required:
 * No original research:

3. Broad in coverage?:
 * Major aspects:
 * Focused:

4. Reflects a neutral point of view?:
 * Fair representation without bias:

5. Reasonably stable?
 * No edit wars, etc. (Vandalism does not count against GA):

6. Illustrated by images, when possible and appropriate?:
 * Images are copyright tagged, and non-free images have fair use rationales:
 * Images are provided where possible and appropriate, with suitable captions:

Overall:
 * Pass or Fail: Cas Liber (talk · contribs) 13:43, 22 August 2019 (UTC)

For bonus points, the references need aligning to a consistent format. You have dates in both "1 Jan 1990" and "1990-01-01" in article. choose one and align others. Similarly authors - some are "Smith J, Jones B", others are "Smith, J.; Jones, B." - pick one format and align others.
 * thank you, will look... I used the citation bot and prior to my edit Dawnseeker2000 did this, not certain if that's enough, I did look hereHelp:Citation_tools (will take to DYK)--Ozzie10aaaa (talk) 15:02, 22 August 2019 (UTC)