Talk:High-density lipoprotein/Archive 1

L
Lechitin-cholesterol acyl transferase (LCAT) is NOT a plama enzyme. This enzyme is present on the suface of HDL. (Francesca Lentini)

Antioxident suppliments block the response of HDL to Simvastatin-Niacin Therapy (Cheung, Zhao, Chait, Albers, Brown - Arterioscler Thromb Vasc Biol. 2001; 21:1320-1326.)

Antioxident combo used was 12.5mg beta carotine, 500mg vitimin C, 400 IU vitimin E and 50 mg of selenium.

HDL increase from statin+niacin therapy was reduced 33% (+25% to +18%) when the antioxidents were added to the statin/niacin therapy.

NIH HATS s(HDL Atherosclerosis Treatment Study) confirmed this observation. Niacin HDL effect reduced from +30% to +20% with antioxidents. Major effect on HDL2. Physical evidence noted in Angiographic and clinical events during study.

---

I believe cortisol is produced in the adrenal cortex (not in the liver as the article currently states).
 * is it supposed to mean serum amyloid A, mentioned at the start of the scentence? Its confusing as its badly worded.

Cat
Every article can be classsified more than one way. So, it is with a lot of mainstream activities like exercise, diet, and even HDL. They are part of natural approaches to health such as Natural hygiene which is classified alternative medicine. I have replaced the orange box with one that doesn't even look like a box. -- John Gohde 07:47, 2 Jun 2004 (UTC)


 * It'd be nice to get a list of the foods that are high-density lipoprotein (HDL)

Well, HDL is not in foods. It is only a lipid particle in the body. Some foods influence HDL levels. Those may indeed be listed. JFW | T@lk  04:50, 28 November 2005 (UTC)

Is it important to mention that drinking more than 1-2 cups, or even that amount in certain individuals, may lead to heart problems? (reference 3) C3045051 04:47, 19 August 2006 (UTC)

toxic level?
Is there a point where the blood HDL level is considered too high or toxic? KBi 01:50, 1 December 2005 (UTC)


 * Not to my knowledge. JFW | T@lk  01:58, 1 December 2005 (UTC)

What is as important as HDL level is HDL function. Is the excess choelsterol in the artery plaque been taken away to be eliminated? Des HDL that has picked up this excess cholesterol deliver it to liver for elimination? The critical issue is that 40% of individuals who develope clinical event (such as a hear attack or stroke) have normal LEVELS of HDL. One reason they still develope clinical event is that their HDL is old. It has not delivered its load to the liver and can not pick up excess cholesterol from artery walll.


 * 1) What exactly triggers a loaded HDL molecule to release its cholesterol load?
 * 2) Is it possible to create injectable HDL (like insulin)? Bioengineer some bacterium to squirt it out?
 * JeramieHicks

Large vs small HDL
This claim that the "large" HDL correlates better with clinical outcomes than "small" HDL. Is there a reference for that? --Slashme 17:33, 15 January 2006 (UTC)


 * Sure. "for HDL, H5-1, with H5, H4, and H3 being the largest particles... H5, H4, and H3, are negatively associated with coronary artery disease, whereas H2 and H1 are positively associtaed with coronary artery disease." Kwiterovich PO. The Metabolic Pathways f High-Density Lipoprotein, Low-Density Lipoprotein, and Triglycerides: A Current Review. Am J Cardiol 2000;86(suppl):5L.

Ulgo 00:27, 3 April 2006 (CET)

The article goes beyond the negative association between large HDL and cardiovascular disease, to claim that large HDL is atheroprotective. Is there any support for this stronger claim? I have seen mechanisms proposed, but I am not aware of research offering strong support. To the contrary, it seems equally plausible that large HDL is a consequence of an active atheroprotective mechanism, rather than a cause. The distinction is important. The causality claim suggests that elevated levels of large HDL should reliably predict freedom from atherosclerosis in an individual, whereas mere association could still show statistically significant trends in a population but still not be useful in predicting disease in individuals. --ErikNilsson (talk) 18:40, 14 December 2007 (UTC)

Restructuring
I did a major restructuring, including a separate section for "Structure and Function", and adding info about treatment and references. I respectfully removed the unverified Oxford trial comment, since it can be misunderstood of even taken out of context. Carloseduardo 15:59, 30 December 2006 (UTC)

Major rewrite needed
This whole article reads like it was written for a medical journal. It should be completely rewritten so that it can be understood by the average person. 66.219.150.35 (talk) 11:47, 3 August 2010 (UTC)
 * Do so on simple.wikipedia.org --John Moser (talk) 16:32, 25 August 2016 (UTC)

Niacin versus Niacinamide
Niacin, (which can lead to "flushing" of the skin), has been proven to raise HDL. Does anyone know if Niacinamide, (a form of niacin, which is ofter found in vitamin supplements, and does not cause "flushing" of the skin), has been tested to see if it raises HDL, and if so, what were the results?204.80.61.10 21:25, 11 January 2007 (UTC)Bennett Turk
 * It would appear that Niacinamide will not raise "good" HDL or lower "bad" LDL. Too bad since Niacinamide is found in most B-vitamin supplements, as well as most multi-vitamins sold in stores.24.195.255.68 00:00, 29 January 2007 (UTC)Bennett Turk

HDL new research
I use the following website for up to date information on HDL research. I feel that it could be worth considering as an external link. www.hdlforum.org/ Thanks, Jane Jane1898 (talk) 12:47, 13 February 2008 (UTC)

Furthermore I completly miss anything about the new therapy with anti-miR33. HDL can be upregulated by blocking (via antisense microRNA) the microRNA-33 (responsible for downregulating ABCA1 expression). For those with acces to PubMed just look for : HDL Cholesterol miR33 — Preceding unsigned comment added by 84.28.72.114 (talk) 10:34, 29 November 2011 (UTC)

Limiting intake of dietary fat to 30–35% of total calories
The article says that "Limiting intake of dietary fat to 30–35% of total calories" is a suggested lifestyle change. That makes it sound like you should get a minimum of 30% and a maximum of 35%. I assume this is actually meant to reflect disagreement between whether 30% or 35% is the maximum. The recommended minimum is somewhere around 10% AFAIK. --220.253.29.116 (talk) 09:33, 20 June 2008 (UTC)

== The page says to remove trans fats from your diet and to add monounsaturated or polyunsaturated foods...

But the link to trans fats has this : "Trans fat is the common name for a type of unsaturated fat with trans- isomer fatty acid(s). Trans fats may be monounsaturated or polyunsaturated."

A complete contradiction? Please clear it up. Thanks Shaun —Preceding unsigned comment added by 41.240.93.182 (talk) 09:47, 28 July 2008 (UTC)


 * No contradiction here, just a misunderstanding. Fats may be saturated or unsaturated. Unsaturated fats may be classified as monounsaturated or polyunsaturated. Unsaturated fats may also be classified as cis or trans. Thus there are cis-monounsaturated, cis-polyunsaturated, trans-monounsaturated, and trans-polyunsaturated fats. Current advice is to eliminate all kinds of trans fats from your diet, while increasing cis fats, especially cis-polyunsaturated fats. --  Solo Owl   20:02, 17 September 2013 (UTC) — Preceding unsigned comment added by Eall Ân Ûle (talk • contribs)

Measurement of HDL
I've tried to start a Measurement of HDL section (a bit like LDL) . Rod57 (talk) 19:42, 12 September 2008 (UTC)

foods to raise hdl
I was looking for foods that help with raising hdl, and I found this:

Among these six spices, beneficial effects on lipid metabolism would probably be in the order: garlic > onion > red pepper/capsaicin > turmeric/curcumin > fenugreek > ginger. http://www.informaworld.com/smpp/content~content=a713632612~db=all

also a study showing that a red onion worked better than a white one. —Preceding unsigned comment added by Luminair (talk • contribs) 12:27, 17 September 2008 (UTC)

I believe the last item in the list of things to raise HDL is wrong. Increasing saturated fats intake to raise HDL???? --Geekish (talk) 21:36, 17 March 2009 (UTC)


 * Saturated fats tend to raise total cholesterol. Total cholesterol is mainly LDL-C + HDL-C + a smaller amount of other stuff.  So saturated fats do indeed raise HDL with lauric acid deserving special mention by raising HDL-C proportionally greater than LDL-C. Lambanog (talk) 07:58, 28 March 2011 (UTC)


 * Oops. Made correction.  HDL-C is different from HDL. Lambanog (talk) 07:58, 28 March 2011 (UTC)

Flush free niacin (inositol hexanicotinate) does raise HDL
The following statement appears to be inaccurate, or at least, contested: "However, niacin products sold as "no-flush", i.e. not having side effects such as "niacin flush", do not contain free nicotinic acid and are therefore ineffective at raising HDL..."

Here are some references indicating that flush free niacin (inositol hexanicotinate) raises HDL:

http://wiki.answers.com/Q/Is_inositol_hexanicotinate_effective_in_lowering_cholesterol

http://www.life-enhancement.com/article_template.asp?ID=7

68.63.209.192 (talk) 04:32, 31 March 2009 (UTC)HighCholesterolGuy


 * Oh boy, oh boy. I checked your references. The first says NO [their emphasis], inositol hexanicotinate has no effect on lipid levels. (Maybe it had a different opinion when you checked it.) The second website is in the business of selling food supplements, so it is not to be considered a reliable source of unbiased information. --  Solo Owl   20:12, 17 September 2013 (UTC) — Preceding unsigned comment added by Eall Ân Ûle (talk • contribs)

Alcohol reference
The ref (17) in the list does not support the statement that purports that alcohol consumption raises HDL, the reference states "Raising HDL-C can be achieved by both lifestyle changes and pharmacological means, the former of which include smoking cessation, aerobic exercise, weight loss and dietary manipulation." A new supporting text needs to be found. Also don't hit the IP with a welcome message, I'm retired and it is dynamic.99.27.12.196 (talk) 04:41, 7 January 2011 (UTC)

== It won't be hard to find support of alcohol raising HDL levels. It is common knowledge among physicians ands there is a ton of work on the alcohol-lower_CVD linkage. (It annoys the anti-alcohol people but is generally accepted as a solid finding these days.) Here's a few: http://www.ncbi.nlm.nih.gov/pubmed/11864868 http://www.ncbi.nlm.nih.gov/pubmed/11734581 http://www.ncbi.nlm.nih.gov/pubmed/9719399 http://www.ncbi.nlm.nih.gov/pubmed/7749823 http://www.ncbi.nlm.nih.gov/pubmed/3987006 http://www.ncbi.nlm.nih.gov/pubmed/3772283 —Preceding unsigned comment added by 71.235.36.31 (talk) 01:15, 22 April 2011 (UTC)

Raising HDL section unclear
Is the section Raising HDL about raising HDL or raising HDL-C? There may be a significant difference between the two. Lambanog (talk) 08:06, 28 March 2011 (UTC)


 * As I understand the structure and function section, I think it is pretty clear that if you increase either one, you will increase the other one. The article also makes clear that neither one absolutely correlates with heart health, and that more research is needed to find out exactly how HDL-particles and artery plaques interact. One hopes that better measurements will appear in a few years. --  Solo Owl   20:18, 17 September 2013 (UTC) — Preceding unsigned comment added by Eall Ân Ûle (talk • contribs)

HDL Subfractions
This page discusses "HDL subfractions", but it neither defines nor describes them. It claims "clinical significance" (weasel words?) for them, but does not specify how they affect health. Come on guys, get with it! --  Solo Owl   20:25, 17 September 2013 (UTC) — Preceding unsigned comment added by Eall Ân Ûle (talk • contribs)

External links modified
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Flaxseed oil et al dispute
The Flaxseed oil citation is WebMD, which carries commonly-held advice. That is to say: if everyone says eggs are bad for you, then WebMD says eggs are bad for you; this isn't a bad position to take, and is the position many doctors will take as well. Omega-3 fatty acids and flaxseed oil are well-known to increase HDL, unless you're looking at PMID 17056811, PMC2989356, or a number of other studies (see "High Blood Cholesterol" section in PMC2989356) which report no effect on HDL concentration by flaxseed.

Likewise, PMID 8054260 shows HDL increases from magnesium supplements in patients with [diabetes|diabeetus]; while PMID 938987 shows HDL improvements in healthy Japanese subjects. There is less research on this topic, and the little I've found suggests a benefit as stated. --John Moser (talk) 16:29, 25 August 2016 (UTC)

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Remove GW501516?
At the bottom of the article, GW501516 is mentioned as a possible drug to raise HDL. However, after reading about it, the side effects of this drug seem to massively outweigh the possible benefits. Would it be a good idea to just completely remove that paragraph? Myoglobin (talk) 02:29, 20 February 2018 (UTC)