Talk:Homochirality

Untitled
what is "chiral transmission"? I am familiar to the field of chirality in chemistry but this term is new to me. It also doesn't appear a standard IUPAC term. Maybe someone should elaborate on this in the article, instead of devoting only two lines to it. I&#39;m with gerrit 03:38, 6 August 2007 (UTC)


 * I have included the reference that I used for that particular segment. I had never heard of it either but it makes a lot of sense: induction-amplification-transmission. V8rik 20:21, 6 August 2007 (UTC)

Optic resolution
On the subject: Okay, it's in Dutch, but what it boils down to is that if you stir long and hard enough, you get an optically pure mixture. Whether it's L or D depends on present contaminations (e.g. a human hair in the mixture triggers formation of D-crystals). If anyone could find an English reference, that would be very handy. 78.21.62.169 (talk) 02:12, 13 June 2008 (UTC)


 * I can't read Dutch, but I've read the JACS article cited there. It doesn't mention anything about hair, but it discusses an experiment in which a racemic mixture of crystals in equilibrium with a basic solution where the compound can epimerize, led to an single enantiomer in the solid state when they added 0.1% of enantiopure phenylglycine. --Itub (talk) 10:04, 13 June 2008 (UTC)


 * Just because it was originally written in another language, doesn't excuse a lack of readibility. Optical resolution has another definition; if you are using another definition, spell it out. Use plain English. Elucidate! Kortoso (talk) 22:41, 13 December 2013 (UTC)

"Chiral amplification" section of the main article
Nitrosobenzene condenses with "active" methylene groups, e.g. of malonic esters, benzylcyanide PhCH2CN etc. by scheme:

Ph-N=O + R-CH2-R' => [ Ph-N(OH)-CHRR' ] => Ph-N=CRR' + H2O,

i.e. carbon of the methylene group bonds with nitrogen atom, not oxigen atom of Ph-N=O (and the resulting bond is C-N bond, not C-O bond).

But this image in the #Chiral amplification section:

shows as methylene of propionaldehyde bonds with oxigen atom of Ph-N=O, forming C-O-bond. Is it a mistake? Krasss (talk) 18:06, 29 September 2009 (UTC)
 * please consult reference number 5 V8rik (talk) 18:51, 29 September 2009 (UTC)
 * Done. Both types of reactions (with C-N and C-O bonds formation) are possible, here is useful link: Asymmetric O- and N- Nitroso Aldol Reaction - an efficient access to a-oxy and a-amino carbonyl compound (PDF, 640 kB). Krasss (talk) 20:32, 29 September 2009 (UTC)
 * Thanks for the info, I take it there are no misunderstandings about the image then? V8rik (talk) 19:00, 30 September 2009 (UTC)

D/L notation vs notation
I suggest we use smallcaps notation instead of D/L to be consistent with the Chirality (chemistry) article. If nobody has an objection I will change it. Sprlzrd (talk) 01:01, 14 April 2015 (UTC)

Frank's model of homochirality
The article lacks a theoretical section explaining the mechanism through which autocatalysis leads to homochirality. I am planning to add a section for Frank's model of homochirality (Frank, F. C. "On spontaneous asymmetric synthesis." Biochimica et biophysica acta 1953), which is the original model that suggested homochirality is a consequence of autocatalysis and explained the mechanism for it. The Soai reaction is the first experimental verification of Frank's mechanism. Any objections? Sprlzrd (talk) 01:10, 14 April 2015 (UTC)
 * Go for it! Cheers, BatteryIncluded (talk) 02:16, 14 April 2015 (UTC)
 * Sounds like a good idea for content. We have an article specifically for the Soai reaction that could use an additional sentence or two about this application of it. We also have an Spontaneous absolute asymmetric synthesis article that might be more appropriate for some of the material you are thinking of writing. DMacks (talk) 04:24, 14 April 2015 (UTC)

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