Talk:Hydrocodone/paracetamol/Archive 1

Trivia section
I removed it as per WP:TRIV guidelines, thought I'd mention it here. TheDapperDan 09:06, 16 May 2007 (UTC)

Brett Favre
Is it notable to put that Brett Favre was addicted to vicodin in the '93-'95 seasons? Pbroks13 16:08, 2 July 2007 (UTC)

Exactly how long does it stay in your system, drug testing-wise74.73.112.170 00:59, 11 July 2007 (UTC)

Bizarre emphasis
This article reads as if it were written for drug addicts or narcotics agents. Very little is said about the pharmacology, indications, contraindications, and other data concerning the drug, whereas most of the article talks about abuse potential, laws, and adulteration of the drug. It needs to be rewritten to get it away from the drug-culture tone and towards a more clinical, professional tone. Agateller (talk) 19:22, 1 November 2008 (UTC)

"generic vicodin" (pills containing Hydrocodone & APAP that aren't technically like the brand)
Might this page also show some pills which are commonly presented as Vicodin, but generic, like at this site, where the pills have a "check mark" like a big "V" on one side. I've seen one like this, but in a different shape which was yellow. 4.242.192.128 (talk) 21:45, 13 November 2008 (UTC)

Other Hydrocodone + other substance pill brands.
Are the following also Hydrocodone + APAP, or is the additional substance an NSAID (like "Vicoprofen" seems fairly obvious from the name it is not APAP but an NSAID.) - Dicodid, Hycodan, Hycomine, Hydroco, Tussionex... Are there any more? 4.242.192.128 (talk) 21:58, 13 November 2008 (UTC)

drugbox fix (cosmetic)
"legal status" in drug box is hard to read. 1. needs space between "III" and "(us)"   2. also, would expect to see "us" as "US" drugbox seems to be a template and i can't quite figure out how to amend. hope someone more skillful will.--71.183.238.134 (talk) 10:37, 8 February 2009 (UTC)

Fiction based (pop culture) references
Is it relevant to add references to fictional works with Vicodin? For example, I think it's irrelevant that Gregory House in House TV series uses Vicodin. Should we also list all fictional works that mention AK-47 in the AK-47 article? I would say famous Vicodin users are relevant, say a famous pop star, but not any reference that is fiction based. I would like to remove the fiction based references. What do you think? Shd 21:23, 8 August 2006 (UTC)
 * I think it's relevant. It isn't just a mention, it's prominently featured in the series (well, that sounds like product placement, but you know what I mean).  I think the point of the pop culture references section is to see what kind of role the drug plays in current pop culture, and for that, fictional references are just as important as real-life ones. --Galaxiaad 22:07, 8 August 2006 (UTC)


 * Seems reasonable to include House, since this show is a part of pop culture.203.213.77.138 04:50, 10 August 2006 (UTC)


 * Yeah, seems relevant to me. Given the prescription drug crisis going on today, mentions of vicodin ought to include their prevalence in pop culture67.86.173.66 21:19, 18 August 2006 (UTC)


 * Especially since almost every single House episode makes several mentions of Vicodin (In fact I came to this page from the House (TV Series) article).


 * Wasn't Rush addicted to Oxycodone instead of Vicodin? The pop culture reference section says otherwise though.PatDonovan130 15:21, 19 August 2006 (UTC)


 * Yeah, and we have a reference for that: Conservative radio host Rush Limbaugh is a famous admitted former OxyContin addict and abuser .  (from the oxycodone article). They're the same type of drug, so it's possible he was addicted to both, but I'll take it out of the article unless/until we get a reference. --Galaxiaad 20:55, 19 August 2006 (UTC)
 * Oy, I should have done a Google search first. I haven't found any really neutral sources, and I have to go now, but there are a bunch of sites that say it was both oxycodone and hydrocodone.  Sorry, will work on it later! --Galaxiaad 21:05, 19 August 2006 (UTC)

The popular culture section contains a lot of passing references to vicodin in movies and songs. Many of these are of questionable relevance. I can see the argument for the house reference, since it's a well-known show and vicodin apparently plays a prominent role. I can see similar arguments for the Eminem and Six Feet under references. I'm going to take out some of the "x took a vicodin in whatever movie" type references though. Feel free to add back anything you think was removed in error.

Once trimmed down, I think the section would be a lot better if it was in prose rather than in list form. This would also discourage the listcruft problem from resurfacing here.--Eloil 21:06, 8 May

I'm changing the heading from "Fiction based (pop culture) references" to just "Pop culture references" since this is both more common for such sections and much more accurate, as it includes the addictions of real people to the drug. I don't think an article benefits from a whole section on fictional references to the topic. Imagine how long the articles for love, sex, war, family, death, murder, crime, the sun, flowers, god... just about anything. If the list is not reasonably comprehensive then it puts undue weight on those that are utterly trivial yet managed to be added, while if it s comprehensive the article would be page after page after page of references... what is gained? I don't really see why it is important some actor was addicted to the drug, but I don't think anything about most actors is important enough to bother with anyhow - I recognize I'm the odd one out there. I don't think the House or Eminem references add much to this article, I would put those in the articles for the series or the artist, but at least they make sense: the drug plays a major role in defining the context of each.

Also, It seems like the reference section has crept back to being a list since you cleaned it up back in May. I will go and remove those that seem unnecessary. This follows the "Be bold" approach, but I will not argue with anyone who wishes to change them back. I only ask that you consider if the entry adds to the article or just makes it longer. Keep in mind that we are expected to try and avoid lists. Thanks. --Fitzhugh 20:57, 28 September 2007 (UTC)

I agree with the original poster. The pop culture references are silly and irrelevant. No one cares if someone said the word "vicodin" in a song. There are many references to vicodin everyday, and we could post every single one of those references, but it wouldn't make the article any better. The few pop culture references seem to be picked out of someone's ass and don't give one a sense of context or what it adds to the drug's notoriety. No one cares if the Stone Temple Pilots mention it in a song. Just get rid of it and add a section about famous vicodin addicts. --Hegemonster

Just removed it again. Pure POV. Zerocannon (talk) 04:03, 22 November 2007 (UTC)


 * Just thought I'd mention that I searched wikipedia for a confirmation that House uses vicodin. Just as I suspected, that particular info was removed from the page that is indexed by google and Wikipedia's own search engine, so I had to go to the talk pages, where, just as I thought, people had come up with arguments to remove that particular bit of useful info to make my life more cumbersome. Mlewan (talk) 12:04, 8 March 2009 (UTC)

How it works
Anyone know how it effects the body chemicly? (as a painkiller) Klosterdev 16:47, 12 September 2006 (UTC)

It binds to mu-opioid receptors in the central nervous system, like other similar drugs such as morphine and oxycodone. This binding affinity is associated with feelins of well-being and relief of pain; your body uses the same receptors for endogenous chemicals generally referred to as endorphins that have a similar function. I believe that this is explained in the main hydrocodone article.

Then again, it may not be. Also, I forgot to mention that since it's hydrocodone combined with acetaminophen that it has some other not entirely understood method of producing analgesia that is most likely related to the inhibition of prostaglandins. Archmage Brian 03:00, 14 September 2006 (UTC)

Krusty the Clown from "The Simpsons" show blames his odd behaviour on the Vicodin.

In the Pharmacokinetics section, the last sentence says that acetaminophen (paracetamol) is a peripherally acting drug, Tylenol is a centrally acting substance, their own website states this: Acetaminophen is a synthetic, nonopiate, centrally acting analgesic derived from p-aminophenol. The link is: http://www.tylenolprofessional.com/pharmacology.html. —Preceding unsigned comment added by Arvinkx (talk • contribs) 23:55, 9 May 2009 (UTC)

behavioral effects references
lots of the citations/footnotes there were for name=Zacny, which to me makes no sense. also marked all as 'citation needed' for other claims that were made in that section. 67.164.96.20 (talk) 06:40, 12 May 2009 (UTC)

increase attention?
it says right now: "People given logic examinations while under the influence of this drug showed an increase in incorrect answers, but spent more time on the exams. This suggests that this drug may be aiding in attention."

this does not sound logical. either vandalism or typo but I've no idea what it should be.


 * Hm. I'd think it was the drugs interference with problem solving abilities effecting how quickly the person can come to a conclusion (A more frequently incorrect one, at that.) But I'm not exactly a doctor. Hazor (talk) 01:29, 3 August 2009 (UTC)

Did someone make the first part bold on purpose?
I added Zydone and noticed that half of the first paragraph is in bold. I am pretty new to Wikipedia and honestly I may have done it on accident. Someone please correct the mistake unless it's done that way for a reason. —Preceding unsigned comment added by Nechy09 (talk • contribs) 01:47, 15 September 2009 (UTC)
 * Fixed, no worries. P.S. New comments on talk pages go on the bottom, and you should "sign" your comments by appending -- . Cheers, --4wajzkd02 (talk)

Behavioral Effects section removed
Entire section reads like a personal blog attempting to warn teenagers against Vicodin addiction. Way too many POV issues. Until someone can bring in references (from a notable medical journal) meriting inclusion for "behavioral effects," this really doesn't belong here. There aren't even substantially documented effects on behavior in the first place. 70.153.101.17 (talk) 06:32, 20 December 2009 (UTC)

Matthew Perry Addiction not sourced
The last line of the "popular usage" category has a single line about Matthew Perry's addiction. It is its own paragraph and completely unsourced, I'm not sure how to mark it but, I would think this would need to be highlighted as unverified. Thanks. 99.39.110.55 (talk) 23:52, 3 August 2010 (UTC)
 * I agree that it doesn't belong without proper sourcing, so I have removed it. -- Ed (Edgar181) 00:23, 4 August 2010 (UTC)

Merge suggestion
To be consistant with other drugs in listed, I would merge. Search for Percocet - it redirects to Oxycodone. Percocet is to Oxycodone as Vicodin is to Hydrocodone - it is a mixture of drugs, usually (in the US, at any rate) done to acheive a lower scheduling (Oxycodone alone is schedule II, but mix it with a dose of Aspirin or Tylenol, and *poof*, it's schedule III.

Thats incorrect. All oxycodone mixtures are schedule II. Oxycodone with APAP(percocet) is still schedule II.

66.41.0.174 22:43, 29 June 2007 (UTC)

They should not be merged. Vicodin is hydrocodone with acetaminophen which makes it a schedule III controlled substance whilst regular hydrocodone preperations are schedule II. The hydrocodone page should include chemical make up, half-life, bioavailibilty, and other more "advanced" information. It should be something more you'd see out of a chemistry book. While the vicodin page should have history of the drug, when it was patented, who manufactors it, dosage sizes, etc. It should be something that someone just prescribed it should read to get a better idea of the medication without information they won't understand (e.g. chemical make-up) They should NOT be merged. -Tunafizzle

There are articles for both Vicodin and Hydrocodone. They're the same thing.

I suggest these articles be merged.

—Preceding unsigned comment added by 69.181.120.218 (talk • contribs) 17:08, 24 July 2006 (UTC)

-No to merging. As with Adderall, Dexedrine, and Benzedrine for amphetamine (same drugs) and Desoxyn for methamphetamine, this is no different.

Instead of merging I suggest an expansion of the "Vicodin" article, including notes about the APAP content in hydrocodone and the problems APAP causes in recreational use. --John Cho 20:41, 26 July 2006 (UTC)
 * Hey. Good point, I didn't realize those pages were that way.  However, I still think we should go along with the guideline on this and merge.  The discussion is over at Talk:Hydrocodone, though, so it'd be a good idea to repost your comment there. --Galaxiaad 02:50, 27 July 2006 (UTC)

The merge is ok, and I wonder if all teh mentions of alchohol and vicodin being used together should be balanced out by cautioniary info (it is possibly a fatal combo) or removed?

Coming down off vicodin and wine, i experienced a severe case of the hiccups, as did my significant other.
 * NB: You shouldn't mix alcohol and paracetamol, it is potentially toxic to the liver. Fuzzform 03:47, 3 May 2007 (UTC)
 * I vote yes to merging, dexadrine, benzedrine and adderall all have importent information not held in the amphetamine article.  vicodin however does not.  I suggest that we add a sub catagory to hydrocodone for vicodin.  In that we can add references in pop culture (there are quite a few) and information regarding specificly abotts manufacture of it.  But this article must go, it is terribly written, contains many inaccuracy's, and lots of unsourced statements.  I will add a subsection to hydrocodone tonight.

P.S. I just had my wisdom teeth removed and happen to be taking hydrocodone for the pain (2x 5/500) so please forgive any stupid mistakes, I am a little foggy.

Foolishben 21:15, 28 November 2006 (UTC)

Don't Merge - If you read the Vicodin article you will see that Vicodin and Hydrocodone are not the same thing; Hydrocodone is the main component of Vicodin. Hydrocodone is a component of Vicodin, because of this it is innapropriate to merge the two together; that would be simmilar to merging Coca-Cola with Caffiene.

VICODIN® is a brand name for hydrocodone with acetaminophen; hydrocodone is the main ingredient and therefore VICODIN®, with all other brand names, belong in the article describing the main ingredient. Caffiene is not the main ingredient of Coca-Cola, believe it or not it is still coca (flavor). Unkown User - 8th December 2006
 * Ignore that comment. It's false. Hydrocodone is vicodin. They are the same. —The preceding unsigned comment was added by 70.188.139.178 (talk) 11:53, 28 December 2006 (UTC).
 * No, ignore that one instead. Hydrocodone is the strongest active ingredient in Vicodin, but it's also Schedule II in the US when alone. Vicodin is Schedule III, because it is hydrocodone and paracetamol/acetaminophen - that's Tylenol or Panadol - in each pill. Vicodin is *not* hydrocodone. It's a mixed product. David DIBattiste 01:18, 4 January 2007 (UTC)


 * I support the merge. The articles on amphetamines listed above are a notable exception. The article co-codamol is also in need of work. It seems that mixed preparations are becoming somewhat of an issue. Vicoden itself (i.e. the brand name version) is rarely prescribed, due to the fact that generic equivalents are available. Fuzzform 03:46, 3 May 2007 (UTC)


 * Weak "don't merge": While the "mixed product" distinction between vic and hydrocodone is an important one to make, it can be made whether or not the merge takes place. The question is more whether there is enough information on the mix to merit a seperate article instead of just a section at Hydrocodone. I think there probably is, given the fact that the mix is prescribed widely and is also treated differently from hydrocodone in the laws of at least one country.


 * If the articles stay seperate, this article needs to make the distinction clearer. Currently the opening sentence treats vic as a synonym for hc. It might also help with clarity if some of the descriptions of effects compared and contrasted vic with hc, e.g. "Like/unlike pure hydrocodone, Vicodin has effects x, y and z." References to studies that compare the two substances would be helpful also, as would more references generally.--Eloil 20:38, 8 May 2007 (UTC)

Strong "don't merge": Vicodin is not available under that name in the UK, one of many places the US Drama "House" is televised, viewers of this TV series see the main character struggling with vicodin addiction yet may want more information about the drug. This heading and article is therefore needed as a reference. ATurtle05 (talk) 12:40, 26 February 2010 (UTC)


 * The problem here is that we have been maintaining four separate articles (hydrocodone, hydrocodone compound, Norco (medication), Vicodin) which individually contained unique POV and underdeveloped commentary about the effects of hydrocodone. Because hydrocodone is obviously the primary drug of interest in these compounds, there is not a great deal of Vicodin-specific information that we can offer our readers—aside the popular culture and obvious risk of APAP-induced liver damage. With your objections in mind, we can consider hydrocodone compound+Norco (medication)→Vicodin, Norco (medication)+Vicodin→hydrocodone–acetaminophen compound, the originally proposed hydrocodone compound+Norco (medication)+Vicodin→hydrocodone, or something else if you have a better idea. Let me know what you think. —  C M B J   09:00, 1 March 2010 (UTC)


 * I just removed the merge tag since this discussion is not really active at all. I like it the way it is. "Hydrocodone compounds", such as Norco, should redirect to this article as Vicodin is definitely the most well known brand name for hydrocodone. I would even argue that the name "Vicodin" is more recognizable in most parts of the US than "hydrocodone". That speculation aside though, this article seems to have enough unique information to stay separate from hydrocodone. LonelyMarble (talk) 21:23, 2 April 2010 (UTC)

Strong " merge" There is no justification for selecting one brand name over another. The most well-known is not known to everyone and therefore no need to propagate incorrect information. All brands of "hydrocodone compounds" should redirect to the main ingredient Hydrocodone. VICODIN® is a registered trademark of Abbot Laboratories for their compound of hydrocodone bitartrate and acetaminophen. Likewise NORCO® is from Watson labs for the same ingredients. Each brand name refers to specific amounts of hydrocodone and APAP (acetaminophen) or compounds of ibuprofen or aspirin for other brands. LORTAB ®, VICODIN®, NORCO®, Maxidone®, Lorcet®, and all other brand names may or may not have their own article, but the generic "Hydrocodone" article should carry practically all of the information in one location without the redundancy now written. Brand names need to show little more than their owners name, compounds, dosages and a link to the main "Hydrocodone" article.Zuschnell (talk) 00:35, 14 January 2011 (UTC)


 * lol. Seriously? Apap is a substance P inhibitor. I'll give you that. However, morphine and hydrocodone are both broken down by the same p450 enzyme. The p4502D6 is responsible for most, if not all, and the p4503A4 is only partially responsible. Also, hydrocodone is broken down into hydromorphone?! hydromorphone is six times more portent than morphine. Hydrocodone is almost as potent as morphine. See a problem? An 8mg dilaudid goes for $40 on the street. Good luck getting even close to that for a Norco... The hepatic cycle listed is partially fictional, and partially, well, partial. It needs completion. Any biochem majors out there? —Preceding unsigned comment added by 75.33.36.53 (talk) 04:34, 19 August 2010 (UTC)


 * Hydrocodone is indeed partially metabolized into hydromorphone. This is similar to how oxycodone is partially metabolized into oxymorphone, and codeine is partially metabolized into morphine. The key work is partially metabolized. The amount varies from person to person, but it is only a small percentage (around 10%). Jersey emt (talk) 19:34, 27 October 2010 (UTC)

Trade Name dominates too much
This article is far too dominated by one trade name. If a market leader there may be notable history/legal cases/news stories worth reporting, but we MUST remove excessive Trade Specific info e.g. in the Legal Status section. As much of this page as possible should be made drug combination specific. I will work on this, but thought I would say so first.

If there is enough notable material for one trade name, then this should be moved to its own separate article, but I doubt it.

Cheers Lethaniol 01:49, 15 January 2011 (UTC)


 * Thank you for starting this. I began adding information to the Norco® article and soon realized this trademark issue went far deeper than adding a few references to that article (see input above in merge suggestions).
 * Somewhere near the beginning of this article there needs to be a statement that Vicodin® is a trademark and that the name is used colloquially to describe hydrocodone/APAP or other combinations of hydrocodone in tablet form. There may be history as to why this is but I have not seen it. The word Vicodin should be replaced with hydrocodone, hydrocodone combination, or whatever is appropriate.
 * The use of the trademark as a description is quite common where I live. I have seen people including physicians refer to hydrocodone/APAP as Vicodin® both verbally and in writing in combinations that Vicodin® does not exist.
 * Zuschnell (talk) 23:01, 17 January 2011 (UTC)

Proposed U.S. ban
Re: “Manufacturers will have three years to limit the amount of acetaminophen in their prescription drug products to 325 mg per dosage unit.”

Does the three years to reformulate them or stop making them altogether start from the 30 June 2009 recommendation or the January 2011 announcement? Dawright12 (talk) 09:17, 27 June 2012 (UTC)


 * Yes, if any hydrocodone product exceeds 325mg of acetaminophen, it cannot be distributed in the US or its territories. Hence, they must reformulate it or remove it from distribution within the US. That is also true of other opioid medications, due to hepatic toxicity of the larger dose of acetaminophen and some dosing regimens. There is a variant that uses asprin that is uneffected and if any pure hydrocodone tablets were in the system, those would also be uneffected.Wzrd1 (talk) 17:39, 24 July 2012 (UTC)
 * I think the answer Dawright12 was looking for was where the 3 years start from. From what I read, 3 year "phase-out" period started with the Jan 2001 announcemnet. -  Stillwaterising (talk) 06:44, 1 October 2012 (UTC)

Article makes no sense now
You can't just change the title and leave the article about Vicodin! It makes no sense at all now! I'm not arguing that the article should be titled one way or the other: "Vicodin" or "Hydrocodone/paracetamol"; It just needs to be consistent. Also note that paracetamol is actually the British word for it... It is called acetaminophen in the USA where this article is most relevant. -Debollweevil (talk) 03:49, 11 February 2011 (UTC)


 * Yes would be best to go with hydrocodone/acetaminophen rather than hydrocodone/paracetamol as it is primarily a US medication. Doc James  (talk · contribs · email) 17:40, 1 April 2011 (UTC)
 * I've been looking into it this. While hydrocodone/acetaminophen has been the #1 drug in the US at least since 2003, this combination drug isn't a popular pain medicine elsewhere in the world as far as I can tell. Because of the FDA's rules of requiring combination medications, and the fact that this mediciation is the only effective opiate (not counting the ineffective drug Tramadol) that's not schedule 2. A poll of Google scholar (with patents and citations unchecked and filtered for article since 2008) reveals and  reveals the following the following hits: "Hydrocodone/paracetamol" = 27, "hydrocodone/acetaminophen" = 537, "hydrocodone/apap" = 67. The ratio of hydrocodone/acetaminophen to hydrocodone/paracetamol is almost 20 to 1! I believe that this medication is primarily a US product, and according to Wikipedia naming policy: Wikipedia policy on naming convention states that, "naming should give priority to what the majority of English speakers would most easily recognize, with a reasonable minimum of ambiguity, while at the same time making linking to those articles easy and second nature." English speakers who wish to read about this American product who are NOT from a country that prefers the name acetaminophen (United States, Canada, Japan, South Korea, Hong Kong, and Iran) can find this drug through a search or redirect. -  Stillwaterising (talk) 10:11, 1 October 2012 (UTC)

Proposed sustained release hyrocodone medication without APAP
Drug company Zogenix has put in an application with FDA for a sustained release for of hydrocodone without APAP:


 * http://www.zogenix.com/content/pipeline/zohydro.htm Zohydro ER™ (hydrocodone bitartrate extended-release capsules)

Since there is no adulterant, and up to 100mg of hydrocodone; "Zohydro ER, classified as a Drug Enforcement Agency (DEA) Schedule II drug product, will carry strict prescription and dispensing rules."

There are news articles about this as well. I think the bulk of the write-up on this medication should be in the hydrocodone aricle, but should also be mentioned here. - Stillwaterising (talk) 07:04, 1 October 2012 (UTC)

which one is the regular vicodin? — Preceding unsigned comment added by 184.56.50.190 (talk) 16:19, 19 October 2012 (UTC)

Indication and Limitations of Use from Zogenix
INDICATION Zohydro™ ER is an opioid agonist, extended-release, oral formulation of hydrocodone bitartrate indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

LIMITATIONS OF USE Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve Zohydro ER for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

Zohydro ER is not indicated for use as an as-needed analgesic.

108.199.42.123 (talk) 22:15, 27 February 2014 (UTC)

Why is there nothing about the history, and when it was first released to be prescribed? What year did it first come out on the market? Who developed it? Woefully inadequate page. — Preceding unsigned comment added by 198.13.232.160 (talk) 09:06, 20 May 2014 (UTC)

Trivia
I removed the song lyric info, as unrefed and trivial. Mentioning the drug in a song lyric is not that relevant, unless the song defined a generation with its drug reference, a la "listening to prozac" and "prozac nation".(mercurywoodrose)50.193.19.66 (talk) 21:54, 10 September 2015 (UTC)

Side effects
Updated common and uncommon side effects. Updated BBW and allergy warning.

Danma26 (talk) —Preceding undated comment added 19:45, 4 November 2015 (UTC)

Edits as of 11/4/15
Intro edits: “marketed under trade names”, included: It exists in tablet, elixir and solution in various strengths for oral administration” cited ECR pharmaceuticals.Removed information regarding annual sales and frequency dispensed in 2012. Streamlined and changed all "paracetemol" to "acetaminophen" in the article after stating they are the same in the introduction. — Preceding unsigned comment added by Kran26 (talk • contribs) 03:53, 5 November 2015 (UTC)

Medical/Rec uses edits: Deleted the “Usage” section because it’s redundant. Copied and pasted it into the “Intro” portion. Added different formulations of the drug, noted it’s reschedule from CIII to CII. Included pregnancy and breast feeding portions. Added special population section: pregnancy, breastfeeding, liver and kidney impairment

PD edit: Removed “This conversion is only somewhat responsible for the effects of hydrocodone” since it is unclear what is meant by “effects”. Removed blood brain barrier summary since it is not cited.

Added citations to sulfation and glucoronidation, COX activity and prostaglandin. Updated half life and peak levels with better resources since the trial originally cited was conducted in chronic dialysis patients so generalizability is questionable. Serotonergic neurotransmission hypothesis has been removed since trial was conducted in rats and not humans and it has not been an established hypothesis. Added mechanism for liver damage. Regulation and proposed bans: arranged the events in chronological order.

Side effects, monitoring edits:

Reworded common side effects section. Added non common side effects below common side effects Central Nervous System: drowsiness, confusion, lethargy, anxiety, fear, dysphoria, psychic dependence, mood changes, impairment of mental and physical performance [1] Gastrointestinal System: constipation [1] Genitourinary System: urinary retention, urethral and vesical sphincter spasm [1] Respiratory Depression: inadequate ventilation [1] Special Senses: hearing impairment, permanent hearing loss [1] Dermatological: rash, itching [1]

Added monitoring section to recommend monitoring for patients with renal and hepatic impairment

Added Black box warning and allergy warning Added interactions: revised "CNS depressants" to respiratory depressants.

Defined what HCP meant: hydrocodone combination products

Removed manufacturer section and Television section — Preceding unsigned comment added by 3shalim26 (talk • contribs) 19:50, 4 November 2015 (UTC)

3shalim26 (talk) 20:12, 4 November 2015 (UTC)

Review of Edits by Group 26
You guys added so much information to this article. It’s an amazing improvement. Your edits are all given in a neutral point of view. All of your edits are cited correctly. It’s great that you cited the package insert/prescribing information. It’s reliable and easy to access. The organization of the side effects and pharmacology sections is great and presented in a way that is very easy to understand. In terms of improving your edits, there’s not much to say. You could consider adding some incidence rates/percentages to the side effects sections. Also, you could consider going into slightly more detail regarding the liver and kidney impairment as the section is very vague. Even though it has a great citation people may not know how to read and understand the information from that website. Also expanding upon the pregnancy section. Most people won’t understand what “pregnancy category C” means. -Group 25 — Preceding unsigned comment added by Laurelcarmichael25 (talk • contribs) 18:59, 9 November 2015 (UTC)

Side Effects: Euphoria, questionable source
On the side effect, Euphoria, I seen that it has [2] on it. I have reviewed the source and didn't find any sufficient evidence on that source that specifically identifies this as a side effect in clinical trials, or clinical settings, that are documented on there.

--ExpertListener95 (talk) 14:46, 23 January 2017 (UTC)

Recent Edit
I just reverted an edit that you made adding: Vicodin/ to the start of the article because this is stated in the next sentence under trade names. ActiveListener95| (˥ǝʇs Ɔɥɐʇ)    05:08, 15 February 2017 (UTC)


 * Thanks :) Notthebestusername (talk) 05:18, 15 February 2017 (UTC)

Vicodin
Since Vicodin has been discontinued by Abbott, how should we refer to it in this article? --jpgordon&#x1d122;&#x1d106; &#x1D110;&#x1d107; 23:25, 6 July 2019 (UTC)

Mechanism of acetaminophen is not 100% clear
So adjusted to "How acetaminophen works is unclear but may involve blocking the creation of prostaglandins. "

Doc James (talk · contribs · email) 11:20, 10 January 2020 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): 3shalim26, Qinx26, Kran26, Danma26. Peer reviewers: StephanieHo25.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 00:06, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 21 August 2018 and 7 December 2018. Further details are available on the course page. Student editor(s): Cbynum1.

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Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 September 2019 and 13 December 2019. Further details are available on the course page. Student editor(s): HwangCP133.

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Move to Hydrocodone/acetaminophen
The combination is almost exclusively made for United States. It's rare in Europe where the term "paracetamol" is used. 99% of hydrocodone is consumed in the United States with virtually all of it used in combination of acetaminophen or ibuprofen. I think the article should be moved to Hydrocodone/acetaminophen as the main landing site. — Preceding unsigned comment added by 2600:8800:1300:A2E:0:0:0:1002 (talk) 23:35, 20 July 2019 (UTC)

These products are available over the counter in UK. Hydrocodone and paracetamol is called Paramol and anyone can buy it. Plus combinations of Codeine and paracetamol and Codeine and ibuprofen are also available over the counter. DC2444991 (talk) 11:53, 4 June 2022 (UTC)

Serotonin syndrome side effect
Serotonin syndrome can't be a side effect of an opioid & NSAID combination drug. Please correct. 37.48.1.82 (talk) 10:04, 7 March 2024 (UTC)