Talk:Hypothalamus/Archive 1

Scientists
I was wondering how did they(scientists) manage to obtain all this info,did they experiment on human being ? —Preceding unsigned comment added by Mynscl (talk • contribs) 16:30, 30 April 2008 (UTC)

phermomones
The existence of a pheromone system in humans is doubted by many scientists. It would be governed by an accessory olfactory bulb, as it is in other species, but it seems humans do not have this organ. I changed the text in the article to reflect this.

smythomes
What can go wrong with the hypothalamus gland, we are @ skool and we need help?

I know that the Hypothalamus is linked with the production of Dopamine, and if deprived of Dopamine, one will get Parkinson's disease. Surf google too.

Here is a hint, it is the connection between the Endocrine system and the Neurological System.


 * I'd really like to see an expansion of the article that includes health problems involving the hypothalamus, as it seems like dysfunction is as important to know as function, and I'm honestly curious. &#39;Kash 03:03, 10 October 2006 (UTC)


 * If anyone has any knowledge in the area, I agree. A section on hypothalamus defects would greatly inprove this article. NightFalcon90909 01:04, 7 January 2007 (UTC)

Nice pic
I really like the saggital section of the human head to show the anatomy! Kd4ttc 17:45, 17 January 2006 (UTC)

Coronal sections from Netter Images
I agree, the saggital section is nice, but I still had difficulty visualizing the proper 3D arrangement of the nuclei. I found some coronal sections (and a space filling model! -- not 3-D/interactive though) from Netter Images and added them to the External Links section. Hopefully the Netter Images are as trustworthy as they are useful (seemingly). I've encountered many of them over time, and they look legit to me. But I've noticed them take an occasional liberty or two, so take the images with a grain of salt.

I'm new to Wikipedia editing, and the links go to a private commercial website, so if I'm going against any editing guidelines or anything, please feel free to delete them. 184.96.106.141 (talk) 23:26, 16 January 2011 (UTC)

Gleng's edits
A number of terms of art were lost with the recent edit. There need to be some reversions, but a complete reversion isn't quite right either. Kd4ttc 23:21, 21 February 2006 (UTC)

Yes I changed some technical terms to natural language equivalents, in particular: thermosensitive to temperature-sensitive glucoceptive to glucose-sensitive synthesizing to producing

I think that there is no reason not to use clear natural language here. There is no loss of meaning, and some gain in intelligibility. I also changed the description of releasing hormones from "stimulating secretion" to "controlling secretion; there perhaps should be a larger edit here - the point is that some factors loosely classed amongst the releasing hormones inhibit secretion, and others are co-factors with little effects alone but act in synergy with others.Gleng 22:40, 22 February 2006 (UTC)

Gleng and I editing this talk page simultaneously:

Gleng: Thanks for reviewing. To expand on this:
 * The hypothalamus links the nervous system to the endocrine system by synthesizing and secreting neurohormones often called releasing hormones is a key concept. The hypothalamus operates my synthesis on demand rather than sythesis with later release. Edited
 * It also contains specialised glucoreceptive neurons (in the arcuate nucleus and ventromedial hypothalamus), which are important for appetite. The preoptic area contains thermoresponsive neurons Glucose sensitive OK. Isn't thermoresponsive a term of art?  Are they really temperature responsive, or do they respond to temperature changes elsewhere and then control TRH? Edited
 * Male and female brains differ in the distribution of steroid receptors, and was changed to estrogen receptors. Shouldn't that stay steroid receptors? Not Edited

Kd4ttc 23:00, 22 February 2006 (UTC)

First off, the article is a very nice example of how Wikipedia can be very technical but still reach a wide audience. I'd keep some of the terms of art thermosensitive for the above reason. Glucoreceptive to glucose sensitive I think is fine. I'd keep something in to bring out the concept that the hypothalamus sythesizes as needed, in distinction to glands like the thyroid that release preformed hormones. It is one of the key discoveries in the organization of the endocrine system. And, who art thou who art so wise in the way of (neuroendocrine) science? (to paraphrase Monty Python) Kd4ttc 23:05, 22 February 2006 (UTC)

Yes... but technically the peptide hormones are produced (by cleavage from a prohormone) not synthesised (assembled from pre-existing components). Although we use synthesised in our jargon way, we are not using in its classical dictionary sense. I am, fairly transparently, Gareth Leng, and you can track me quite readily on Google. Gleng 23:15, 22 February 2006 (UTC)

And no - the hypothalamic peptides are stored (in vesicles in nerve terminals). mRNA expression is rapidly up-regulated on stimulation, but this just replenishes the depleted stores of released hormone, and the protein expression and transport to release sites takes some hours. Neurons in the VMH and some elsewhere in the hypothalamus are both directly temerature sensitive and respond to peripheral temperature changes. On steroid receptors - I'm sure about estrogen receptors, not sure about dimorphisms in the others, maybeGleng 23:30, 22 February 2006 (UTC)


 * Holy cow! Someone with real knowledge of a subject that is contributing to wikipedia!  This is great!!  It is so nice to see someone with real knowledge around here.  It is amazing so much on Wikipedia is correct, given the editing style.  I also appreciate seeing someone in academics who is actually interested in getting medical science knowlege into the hands of general readers.  I am sure you know what I mean, but I think it is important to celebrate individuals that are interested in teaching and education.  Well, in my interpretation of the tradition of Wikipedia, now that I've started some commentary and see myself educated through the process (I forgot the clevage bit) I'll bone up a bit and add to explaining the secretion concept.  I had a hint you had some sophistication when you alluded to details of hormonal action.  It's just you were using such good english I didn't imagine you were in academics.  Steve Kd4ttc 23:35, 22 February 2006 (UTC)

Control of food intake by hypothalamus
I've suggested the article Control of food intake by hypothalamus be merged with this one, as it's an unlikely search title and the article is small enough to fit into a section in this article. --Canley 15:16, 24 October 2006 (UTC)

Someone put in "Deleted "WHO CREATED THESE HYPOTHESES????" under Control of Food Intake. I deleted it. 198.232.63.66 15:00, 12 December 2006 (UTC)

This section is woefully outdated. No mention of the action of ghrelin on either the arcuate nucleus or the lateral hypothalamus. Any experts fancy updating this? — Preceding unsigned comment added by 158.223.169.85 (talk) 13:28, 28 May 2011 (UTC)


 * If you don't do it, it probably won't happen. Experts are in short supply around here. Looie496 (talk) 01:45, 29 May 2011 (UTC)

Possible problem
What does "se Coty MP crete GnRH" means? It's in the end of the first section. Is it wrong, or did I misunderstood it?

Sexual dimorphism clarification
In the Sexual dimorphism section the phrase "sex of rearing" appears in the third paragraph from the bottom. Would someone be able to clarify that phrase?

Here is the full paragraph:

In primates, the developmental influence of androgens is less clear, and the consequences are less complete. 'Tomboyism' in girls might reflect the effects of androgens on the fetal brain, but the sex of rearing during the first 2-3 years is believed by many to be the most important determinant of gender identity, because during this phase either estrogen or testosterone will have permanent effects on either a female or male brain, influencing both heterosexuality and homosexuality.

Thanks,

Jolon.

--203.144.31.109 01:53, 21 December 2006 (UTC)

This seems very weird, I've never heard any scientist even suggest the possibility that upbringing might affect hetero- or homosexuality. —Preceding unsigned comment added by 80.216.168.244 (talk) 06:59, 9 February 2009 (UTC)

Dambig?
Would it be worth placing a disambiguation notice to Hypophthalmus at the top of the page? Not sure how many'll be looking for one and finding the other. GeeJo (t)⁄(c) &bull; 03:23, 29 June 2007 (UTC)

I say yes, why not. Don't know how to do it though. IceDragon64 (talk) 23:25, 21 July 2008 (UTC)

Tuberomamillary Nucleus
I believe the tuberomamillary nucleus also be included in the posterior. It is responsible for histamine production and thus arousal. —Preceding unsigned comment added by 71.67.122.124 (talk) 23:46, 31 May 2009 (UTC)

Is it just me, or does one of the pictures look like it is just scribbles made by a kid?
Really, it does. Look at the scribbles. I don't even know what it is suppose to portray. —Preceding unsigned comment added by 210.4.96.72 (talk) 20:31, 25 October 2010 (UTC)
 * Well, it makes sense to me -- but then I have more experience than most people in looking at 3D reconstructions. It is certainly crude, but my inclination is to say that it adds value to the article on the whole. Looie496 (talk) 17:13, 17 January 2011 (UTC)

Is there any link, as some have suggested...to causing hypothyroidism
Is there any link, as some have suggested...to damage to the Hypothalamus causing hypothyroidism and possibly being linked in some way to diabetes caused by weight gain from overactive appetite? — Preceding unsigned comment added by 50.103.166.174 (talk) 10:19, 14 February 2012 (UTC)