Talk:ISRIB

Study observes that ISRIB reverses age-related mental decline
This is about a primary source that, as such, does not meet WP:MEDRS & is thus not usable in this article.

Please be on the watch for review articles (especially systematic reviews) published in reputable medical journal (from WP:MEDRS) that discuss this article.


 * (an areticle about the primary source)

The eLife article states that it is a selective, not for profit peer-reviewed open access scientific journal for the biomedical and life sciences. Peaceray (talk) 23:48, 7 December 2020 (UTC)
 * (the primary source itself)


 * @Peaceray This article never mentions efficacy is in rodents only. 2603:6000:D700:194D:B9AA:2612:8AE3:60A2 (talk) 17:55, 31 January 2023 (UTC)
 * I beg to differ. When one reads the first citation, its second heading is Rapid Rejuvenation of Mental Faculties in Aged Mice Implicates Reversible Physiological ‘Blockage’ Behind Age-Related Cognitive Losses & the second citation mentions mice in the title. Peaceray (talk) 18:06, 31 January 2023 (UTC)

JSmol link seems to be broken
I get:

ERROR opening https://cactus.nci.nih.gov/chemical/structure/O%3DC%28COC1%3DCC%3DC%28Cl%29C%3DC1%29N%5BC%40%40H%5D2CC%5BC%40%40H%5D%28NC%28COC3%3DCC%3DC%28Cl%29C%3DC3%29%3DO%29CC2/file?format=sdf&get3d=True -- O%3DC%28COC1%3DCC%3DC%28Cl%29C%3DC1%29N%5BC%40%40H%5D2CC%5BC%40%40H%5D%28NC%28COC3%3DCC%3DC%28Cl%29C%3DC3%29%3DO%29CC2 could not be loaded.

Is this temporary? If not, is it wide spread to other molecules? — Preceding unsigned comment added by 27.32.95.28 (talk) 08:52, 13 December 2020 (UTC)


 * There's no link to  on the generated page, and that link also seems to work now. I'm not sure what was broken, but it looks to be fixed now. grendel&#124;khan 18:28, 9 February 2021 (UTC)

Rewording required.
Cognitive improvements are in murine(rat and mouse) studies only. Absolutely No Human Studies (should be in bold letters) before any claims of efficacy. 2603:6000:D70A:BC00:CD7B:5C6:9C43:B886 (talk) 17:09, 28 May 2022 (UTC)