Talk:Idiopathic pulmonary fibrosis

Diagnosis
So a diagnosis of IPF is essentially saying "bad lungs, but we don't really know what else to call it because we eliminated all of the conditions we know more about"? &mdash; Rickyrab | Talk 05:01, 2 December 2007 (UTC)


 * No. IPF is well-characterized; it is a definite disease in itself. Axl (talk) 14:51, 5 March 2008 (UTC)

"The diffusing capacity for carbon monoxide (DLCO) is invariably reduced in IPF and may be the only abnormality in mild or early disease. Its impairment underlies the propensity of patients with IPF to exhibit oxygen desaturation with exercise."

This passage is interesting, but does not have a logical flow. Any further elucidation as to why CO2 transfer affects O2 transfer specifically at exercise would be useful. —Preceding unsigned comment added by 78.150.47.102 (talk) 08:54, 21 March 2009 (UTC)

Um, has anyone noticed the "clowns attempting to murder you" insert in the second paragraph? I'm a newbie, so I don't feel authorized to cut that out, but will someone please cut that out? Marshagalinsky (talk) 09:46, 4 July 2009 (UTC)

redirect Fibrosing alveolitis?
List of diseases (F) has redlink "Fibrosing alveolitis". Make Fibrosing alveolitis a redirect to Idiopathic pulmonary fibrosis? --EarthFurst (talk) 19:09, 13 July 2009 (UTC)

Treatment Alternatives for "Pulmonary Fibrosis". Is the use of "Enzymes" ever been recorded in treating this condition? —Preceding unsigned comment added by Special:Contributions/Nikos Kourasis (User talk:Nikos Kourasis) 16:27, 14 July 2009 (UTC)

Need radiology image showing honeycombing
The Radiology subsection could do with an X-ray image showing honeycombing - and perhaps a normal image for comparision. - Rod57 (talk) 10:27, 13 May 2011 (UTC)

Cause of disease
Can tobacco smoking or second-hand smoke cause this disease? --Hartz (talk) 18:46, 2 January 2013 (UTC)

Incidence
1) Incidence is the wrong term for this paragraph unless statistics regarding number of new cases are included. Incidence does not relate to mortality statistics.

2) The section cites the BMJ Thorax study of 2011 to support the claim that 5000 people die each year as a result of IPF. This is incorrect as the study actually cites the number of new cases (ironically the incidence of the disease) as being roughly 5000 new cases per year. Mortality statistics for England and Wales, based on this study are quoted at 3019 in 2008 based on ONS statistics from the same year.

This should be corrected, it’s not a joke
Idiopathic pulmonary fibrosis Some well known cases of IPF include: •	Evel Knievel, legendary stuntman •	Steve Gerber, co-creator of the satiric comic book character Howard the Duck •	Robert Goulet, singer

Above are the causes now listed for this disease. The Mayo clinic lists causes below at : http://www.mayoclinic.com/health/pulmonary-fibrosis/DS00927/DSECTION=causes

Occupational and environmental factors http://www.mayoclinic.com/health/pulmonary-fibrosis/DS00927/DSECTION=causes

Long-term exposure to a number of toxins and pollutants can damage your lungs. These may include: •	Silica dust •	Asbestos fibers •	Grain dust •	Bird and animal droppings Radiation treatments Some people who receive radiation therapy for lung or breast cancer show signs of lung damage months or sometimes years after the initial treatment. The severity of the damage depends on: •	How much of the lung was exposed to radiation •	The total amount of radiation administered •	Whether chemotherapy also was used •	The presence of underlying lung disease Medications Many drugs can damage your lungs, especially: •	Chemotherapy drugs. Drugs designed to kill cancer cells, such as methotrexate (Trexall) and cyclophosphamide (Cytoxan), can also damage lung tissue. •	Heart medications. Some drugs used to treat irregular heartbeats, such as amiodarone (Cordarone, Nexterone, Pacerone) or propranolol (Inderol, Inderide, Innopran) may harm lung tissue. •	Some antibiotics. Nitrofurantoin (Macrobid, Macrodantin, others) and sulfasalazine (Azulfidine) can cause lung damage. Medical conditions Lung damage can also result from: •	Tuberculosis •	Pneumonia •	Systemic lupus erythematosus •	Rheumatoid arthritis •	Sarcoidosis •	Scleroderma Idiopathic pulmonary fibrosis: When the cause isn't known The list of substances and conditions that can lead to pulmonary fibrosis is long. Even so, in most cases, the cause is never found. Pulmonary fibrosis with no known cause is called idiopathic pulmonary fibrosis. Researchers have several theories about what might trigger idiopathic pulmonary fibrosis, including viruses and exposure to tobacco smoke. And because one type of idiopathic pulmonary fibrosis runs in families, heredity also is thought to play a role. Pat Wesp August 2,2013 — Preceding unsigned comment added by 72.231.220.170 (talk) 19:26, 2 August 2013 (UTC)

mold exposure
https://www.ncbi.nlm.nih.gov/pubmed/9571528 and other sources mention mold exposure as a correlated factor. Also http://phys.org/news128668851.html mentions a PLOS study about a new diagnostic marker. Could someone versed in MEDRS look these over and decide whether to put them in the article? 70.36.142.114 (talk) 03:04, 2 May 2014 (UTC)

Sourcing for the Epidemiology section
Since IPF is currently in the news, I had a quick look for recent reliable medical sourcing for the Epidemiology section. I think  might be useful here, as it is a relatively recent review (2012) of the frequency of the disease that aims at a global perspective. 109.153.156.71 (talk) 17:28, 3 October 2014 (UTC)

New guideline
10.1164/rccm.201506-1063ST~ new American guideline. JFW &#124; T@lk  19:42, 25 August 2015 (UTC) JFW &#124;  T@lk  19:42, 25 August 2015 (UTC)

Lancet
10.1016/S0140-6736(17)30866-8 JFW &#124; T@lk  20:49, 14 May 2017 (UTC)


 * And now NEJM 10.1056/NEJMra1705751 JFW &#124; T@lk  23:16, 12 May 2018 (UTC)