Talk:Imipramine/Archive 1

Untitled
There's so much more to say, isn't there? I mean come on... the first antidepressant?

The following should re rewritten (not copied) and added: Indication: For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.

Pharmacology: Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.

Mechanism of Action: Imipramine works by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. It binds the Sodium-dependent serotonin transporter and Sodium-dependent noradrenaline transporter, preventing or reducing the reuptake of norepinephrine and serotonin by nerve cells. As norepinephrine and serotonin are used to stimulate the synapse, and depression has been linked to a lack of stimulation of the recipient neuron at a synapse, slowing the reuptake of these neurotransmitters allows them to remain in the synaptic gap longer than it normal, increasing the stimulation of the recipient neuron and relieving the symptoms of depression. However, it does not act primarily by stimulation of the central nervous system. The clinical effect is also hypothesized as being due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings.

Absorption: Rapidly and well absorbed after oral administration

Toxicity: Oral, rat LD50: 355 to 682 mg/kg. Toxic signs proceed progressively from depression, irregular respiration and ataxia to convulsions and death.

Protein Binding: 89–95%

Biotransformation: Exclusively hepatic. Imipramine is converted in the liver to desipramine and 2-hydroxydesipramine, both active metabolites.

Half Life: 11–25 hours

edit request (article repair)
Someone erased the last part of the dosage section and put "and mom is awesome". —The preceding unsigned comment was added by 72.73.126.196 (talk) 04:54, 29 January 2007 (UTC).

I believe we're searching for the perfect quick fix drug that where forgetting the origional and best. plants in nature use multiple chemicles just like we should look to compound preperations for many prescriptions are of multiple drugs. —Preceding unsigned comment added by 80.193.69.13 (talk) 15:58, 18 March 2008 (UTC)

edit1
I can't find anything about this: >>Imiparmine also has activity at sigma opiate receptors as well as substantial activity at D1 and D2 dopamine receptors.[1] Enhancement of brain dopamine activity has been implicated in Imipramine's ability to stimulate motor activity and prolong time spent in escape in mice.<< in the referred link !! and I have tried to verify the information without result so I think it is fair to erase this above part.

edit2
Apologize ! when trying to edit I noticed it was just an "empty" ref tag that was supposed to link to http://www.ncbi.nlm.nih.gov. Now I have made it an external link.

Side Effects: Jaundice
I was on this at a fairly young age, and during one of the routine bloodtests, they found excessive billirubin in my blood, after investigating the issue and such, it was decided to stop my Tofranil, and switched me to Paxil. Even now I still have excessive billirubin in by blood, which is known to be current because of numerous liver health blood tests done to ensure hepatic health during my hormone replacement therapy.

I've been diagnosed with Gilbert's Syndrome pronounced which is essentially the name of ideopathic jaundice. It's reasonable to speculate that the Tofranil began a chain of events causing Jaundice, which then became ideopathic, and chronic.

Considering this is one case, and a personal attestation of fact, it's not reasonable to include in the article, but *shrug* thought some people might be interested in knowing that Tofranil-induced Jaundice might not stop when the treatment ends. --Puellanivis 18:51, 17 October 2007 (UTC)

Gilbert's Syndrome isn't idiopathic, its the most common genetic cause of hyper bilirubinemia, and its benign.

opiod?
Cannot find anything for confirmation on opiod receptor. Please specify sources, thanks Artkin (talk) 15:22, 14 December 2007 (UTC) imipramine does have substantial activity at D1, D2 and to a lesser degree at U opiod receptors.

Uses
It's proscribed to me for bladder, so how does it work for that. Blaylockjam10 (talk) 19:36, 9 June 2008 (UTC)

Copyright problem removed
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History paragraph re-wording
It currently reads: "At the advent of SSRIs, its sometimes intolerable side-effect profile became less tolerable. Therefore, it became extensively used as a standard antidepressant and later served as a prototypical drug for the development of the later-released tricyclics." The first sentence is hard to understand for starters. More importantly, the second sentence seems to contradict the first. If by comparison to SSRIs, imipramine's already intolerable side effects came to be seen as even less tolerable, then why would it "therefore" come to be used as a standard AD treatment? Can others make sense of this? --1000Faces (talk) 19:16, 16 December 2009 (UTC)

"At the advent of SSRIs, its sometimes intolerable side-effect profile became more tolerable"

wHAT DOES THIS MEAN - IT SEEMS LIKE GIBBERISH TO ME, AND WHOULD BE REMOVED JONATHAN  — Preceding unsigned comment added by 144.135.4.48 (talk) 00:02, 22 August 2011 (UTC)

Huh?
"At the advent of SSRIs, its sometimes intolerable side-effect profile became more tolerable."

This makes no sense. Imipramine is not an SSRI, so how could their advent make its side effects more tolerable? Tad Lincoln (talk) 05:37, 3 September 2011 (UTC)

Overdose section
The following section was unsourced, so I am moving it here until it is sourced, per WP:VERIFY. This also had a "how to" tag that was just removed. We should consider removing those aspects.


 * Overdose

The symptoms and the treatment of an imipramine overdose are largely the same as for the other tricyclic antidepressants. Cardinal symptoms are cardiac (tachycardia, widened QRS complex) and neurological disturbances. Any overdose or suspected overdose of imipramine is considered to be a medical emergency as it can result in death without prompt medical intervention. If an overdose is confirmed or suspected the local poison control should be contacted immediately, and the victim should be taken to the nearest emergency room as soon as possible. The victim should not attempt to transport themselves to a medical facility, if no other person is available to transport the victim then an ambulance should be summoned to take the victim to the closest emergency room for overdose management as quickly as possible. Do not wait until overdose symptoms have presented, regardless of whether or not the overdose is confirmed, as symptoms can escalate quickly after they appear and at this point it may not be possible to reach a medical facility before death occurs.

- Jytdog (talk) 05:32, 18 February 2016 (UTC)

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Sometimes (not always) entering "Trimipramine maleate" into the wikipedia search box wrongly redirects to "Imipramine" (https://en.wikipedia.org/wiki/Imipramine).
The below bad redirect does *not* always occur, sometimes the redirect performs correctly.

Sometimes (not always) entering "Trimipramine maleate" into the wikipedia search box wrongly redirects to "Imipramine" (https://en.wikipedia.org/wiki/Imipramine). But note, othertimes entering "Trimipramine maleate" into the wikipedia search box correctly redirects to "Trimipramine" (https://en.wikipedia.org/wiki/Trimipramine).

I DO NOT KNOW HOW TO FIX THIS "inconsistent redirection error" (see above), so I entrust this to someone who can make the fix. — Preceding unsigned comment added by 174.16.149.240 (talk) 02:11, 1 May 2018 (UTC)