Talk:Immunoglobulin G

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This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 16:28, 10 November 2007 (UTC)

Question: Is IgG actually secreted in the breast milk of humans? I have found no information to back this up. I believe only IgA is secreted in the breast milk. IgG does pass to the child via the placenta so that may have been the source of the confusion. — Preceding unsigned comment added by 173.240.238.79 (talk) 14:43, 27 March 2012 (UTC)

Most abundant immunoglobulin
The article states IgG is the most abundant immunoglobulin. However the article on IgA states More IgA is produced in mucosal linings than all other types of antibody combined (...). Which one is correct? Is the article on IgA only referring to mucosal linings? How much IgG is there compared to IgA (overall/blood/gut)?

I have little to no experience in immunology, maybe someone could clarify this.

Cheers, JS 129.67.77.81 (talk) 17:14, 16 November 2010 (UTC)


 * OK, I have deleted the section most abundant immunoglobulin because the reference is probably only referring to serum immunoglobulin as 75% of the TOTAL immunoglobulin in the body is made up by IgA (according to Macpherson and Slack, 2007).


 * Cheers, JS 129.67.77.81 (talk) 15:05, 24 November 2010 (UTC)


 * "IgG is the predominate isotype (approximately 70%-75% of the total Ig) in the blood and extra vascular compartments." ... "IgA is the dominant immunoglobulin isotype in the mucosal secretions, as well as in breast milk and colostrum." - Fundamental Immunology, 2008, 6th ed. William E. Paul Ed. pg 142. Bloomingdedalus (talk) 03:23, 8 July 2011 (UTC)

Low-frequency internal motion
What is this? Why is it here? This kind of analysis seems to be solely a project of Chou and I haven't seen the application of this technique spread much further than citations by this author. Does this need to be on the main page for IgG? It seems to be confusing things - if it's true or not, it doesn't appear to be very relevant. — Preceding unsigned comment added by 195.65.131.154 (talk) 08:03, 10 October 2011 (UTC)

NEJM Review on IgG4 related disease
Should be included http://www.nejm.org/doi/full/10.1056/NEJMra1104650 Wawot1 (talk) 03:50, 11 February 2012 (UTC)

Use as diagnostic
I just made this edit contributing content from a public health campaign about overuse of medical resources. In this campaign, American Academy of Allergy, Asthma, and Immunology was asked to make some suggestions about some diagnostic tests which are commonly used but for which there is no evidence indicating that the diagnostic results in better outcomes. One of the items they proposed is an end to IgG testing as a diagnostic for allergies, and I cited that and a review article saying the same thing. I posted that information here, but I was wondering if that indicates that IgG measurement is a diagnostic for something else or the source of the idea that measurement of IgG can diagnose something came from somewhere.  Blue Rasberry   (talk)   19:29, 30 August 2012 (UTC)


 * A great section; surprised there isn't more on it here already. Makes me wonder if this topic is addressed somewhere else - maybe something a moderator of these pages could help with. In response to your question, IgG is commonly used to diagnose immunity to pathogens, usually viral ones. I added to this section based on information from the Quest Diagnostics 2012 Directory of Services Manual. Couldn't find a copy to properly cite it, though.--157.139.50.92 (talk) 19:21, 28 October 2012 (UTC)
 * Thanks - here is what you did. I just referenced your statement to that publication - if anyone can develop the citation to make it proper then that would be helpful.  Blue Rasberry    (talk)   16:56, 26 November 2012 (UTC)

The latest source regarding diagnosis for food allergies is from 2012. However, my short check on google scholar has not yielded any studies arguing to the contrary. Younger sources could potentially be included, e.g. Hypochonda (talk) 12:52, 30 May 2022 (UTC)Hypochonda
 * Wong 2021 https://doi.org/10.1016/j.anai.2021.01.022
 * Lee 2017 DOI:10.12809/hkmj176310


 * Hay 14.244.49.225 (talk) 23:05, 4 April 2023 (UTC)

Subclasses - mistake ?
In the subclasses section, the table seems to contradict the text.

Text speaks of IgG3 being low-affinity and IgG1 & IgG2 being high affinity whereas the table says that IgG2 is low affinity.

I'm not sure what the right answer is myself, but I don't think it can be both. — Preceding unsigned comment added by 2601:8:9D80:F7:BD95:2ADD:397A:8F14 (talk) 00:11, 4 May 2014 (UTC)

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