Talk:Innate immune system

Some additions
I think physical barriers and normal bacterial flora should be added to this article. They are both very important. Adenosinetalk 06:15, 2 January 2007 (UTC)


 * they are present in the more general article, as anatomical barriers are not part of the innate response. Horia 05:27, 12 April 2007 (UTC)

-The Innate system is NOT non-specific, it is Broadly-specific. — Preceding unsigned comment added by 62.31.54.19 (talk) 18:01, 24 February 2013 (UTC)

Complement
VERY nice entry on plant immunity. I was very glad to see this. Eperotao (talk) 02:00, 18 June 2014 (UTC)

Problem with source four
Hello! I was reading through the section on anatomical barriers, and I wanted to go to your source page to read a little bit more on the topic. Unfortunately, the link brought me to a page that said the article had been removed. --Matheny6 (talk) 01:30, 23 March 2017 (UTC)

External links modified
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Introduction has narrow view of innate immunity re: pathogenic challenge
I was struck by the complete lack of antimicrobial peptide mention throughout the article, except in the invertebrate section with the weak emphasis that "these are conserved." Yet it is directly antimicrobial proteins like human Cathelicidin-derived LL-37, alpha- and beta-Defensins, and peptides like Histatins and Dermicidin that form a prophylactic antimicrobial response to head off pathogens without allowing infection to establish in the first place. This layer comes in to play before resident macrophages and dendritic cells are alerted to major invasion, and is responsible in large part for e.g. the antimicrobial properties of lung mucus (see LL-37 and beta-Def in cystic fibrosis literature), and things like Dermicidin are secreted in the surface epithelia to suppress would-be dermatitis and eczema. Histatins and other peptides are secreted in tear ducts to flush and suppress pathogens in the eye socket, and all these peptides and more are highly expressed in the gut to regulate the gut microbiota and prevent dysbiosis (though mechanistic understanding there is more limited). Just thinking this article would benefit from incorporating the view of innate defences present prior to a somewhat systemic response. Antimicrobial peptides are a well-understood example of how innate immune peptides are constantly protecting the body from would-be invasion, which would lead to chronic inflammation in their absence (suggested as mechanism for some auto-inflammatory diseases). Crawdaunt (talk) 22:27, 6 December 2021 (UTC)

Mucosal associated invariant T cells
Shouldn't Mucosal associated invariant T cells be added in the article? --kupirijo (talk) 12:18, 10 June 2022 (UTC)

Lead Image
The text in the lead image is too small to read. When clicked on, you can only see one group of flowchart bubbles at a time. I suggest the image be revised for easy viewing. 17 March 2023 — Preceding unsigned comment added by 168.91.171.110 (talk) 18:18, 17 March 2023 (UTC)