Talk:Isoflurane

Alzheimers?
Isoflurane is implicated in causing Alzheimers. See the related articles:

http://www.delnor.com/blank.cfm?print=yes&id=154&action=detail&ref=17193 Anesthetic Linked to Alzheimer's Risk

http://www.medpagetoday.com/Neurology/AlzheimersDisease/tb/5008 Cell Culture Experiments Link Florane to Dementia

http://www.rxpgnews.com/alzheimersdisease/isoflurane-may-set-off-a-process_printer.shtml Alzheimer's Isoflurane may produce Alzheimer's-like changes in the brain By Massachusetts General Hospital, Feb 8, 2007 - 3:56:30 AM

http://news.bbc.co.uk/2/hi/health/6334263.stm Anaesthetic linked to Alzheimer's —Preceding unsigned comment added by NescioNomen (talk • contribs) 18:40, 2 October 2007 (UTC)

There are many other articles that support this research. Please add to this list, along with your comments and personal experience.


 * When talking about science "Cause" is a very big word. When you say "there are many other articles that support this research", probably you are not really aware what a primary font is. The links that you gave are just from some news websites, and they all refer to the same study.


 * That isoflurane *may* increase the risk of Alzheimer is still very debatable.
 * 1) When looking at properly peer-reviewed articles (i.e. not just news site, but for instance by searching Pubmed) you will see that a query "isoflurane alzheimer" only returns 18 articles most of which do not refer to isoflurane causing Alzheimer's.
 * 2) There are only 2 main articles that "prove" the link: they are from one single group, and the study have been made on cell cultures, not in vivo.
 * 3) In a real situation is a) very unlikely that a person would be exposed to the same doses of isoflurane for so long (6h) and b) very unlikely that this exposition would be continued in time.


 * So, definitely I would not say it is so indispensable to add that to the article. Gould80 (talk) 15:15, 11 June 2010 (UTC)

Analgesia
The article claims that isoflurane has an analgesic effect without citing any source. This is very disputed (e.g. a study that claims the opposite: http://bja.oxfordjournals.org/content/75/1/55.short), in general inhalational anaesthetics are not considered to be analgesic.
 * The article you link specifies "subanaesthetic" concentrations. But other reports indicate that in the concentrations used for anesthesia, there is also an analgesic effect.  See for example: Improved postoperative analgesia with isoflurane than with propofol anaesthesia.  -- Ed (Edgar181) 13:25, 30 August 2011 (UTC)