Talk:Isotype (immunology)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle5.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 00:55, 17 January 2022 (UTC)

Definition
Not sure this is the correct title for this page, unless it is expanded to mention other types of immune system related molecules. An isotype usually refers to any related proteins/genes from a particular gene family. If antibodies are all this article is about, then maybe the page should be renamed Immunoglobulin isotype. Ciar 05:35, 21 April 2007 (UTC)


 * As it is now, this article seems to confuse immunoglobulin isotypes and types of polypeptide chains. Since I have not been active in this area of Wikipedia I hesitate to make significant changes, but it seems to me that unless this article is much expanded the information in it (corrected) could perfectly well be located in the "Isotypes" section of the "Antibody" article. 24.36.35.188 (talk) 14:36, 16 April 2008 (UTC)


 * Thank you for your suggestion. When you feel an article needs improvement, please feel free to make those changes. Wikipedia is a wiki, so anyone can edit almost any article by simply following the  link at the top. The Wikipedia community encourages you to be bold in updating pages. Don't worry too much about making honest mistakes — they're likely to be found and corrected quickly. If you're not sure how editing works, check out how to edit a page, or use the sandbox to try out your editing skills.  New contributors are always welcome. You don't even need to log in (although there are many reasons why you might want to).  WhatamIdoing (talk) 15:31, 16 April 2008 (UTC)

Thinking about Adding Recent Research to Wiki Page
I am taking an immunology class and one of our assignments is to leave meaningful edits to a wiki page relating to the things we've learned in class. I chose to focus on this Wiki page because it was rated as a stub, and would love to make a meaningful impact as a new Wiki user. I've gathered a few sources (listed below) and I would appreciate it if you could take a few moments to take a look at these and let me know what you think about their viability. Thanks! Immcarle5 (talk) 04:53, 1 February 2016 (UTC)

- Stavnezer, J., Immunoglobulin class switching, http://www.sciencedirect.com/science/article/pii/S0952791596800586; doi:10.1016/S0952-7915(96)80058-6

- Tong, P., Wesemann D.R., Molecular Mechanisms of IgE Class Switch Recombination, http://link.springer.com/chapter/10.1007%2F978-3-319-13725-4_2; doi: 10.1007/978-3-319-13725-4_2

- Panda, S., Ding, J., Natural Antibodies Bridge Innate and Adaptive Immunity, http://www.jimmunol.org/content/194/1/13.long, doi: 10.4049/​jimmunol.1400844

- Xu, Y., et al., No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory, http://www.nature.com/cr/journal/v24/n6/full/cr201465a.html


 * See here for some of my proposed edits. Immcarle5 (talk) 05:05, 10 February 2016 (UTC)
 * Isotypes are distinct forms of light or heavy chains which are present in all members of a species, encoded at distinct genetic loci. [Kappa and lambda are isotypes of light chains. Delta (δ), gamma:1 (γ1), etc. are isotypes of heavy chains.] All isotypes can be readily found in normal sera [see serum(Wiki link)]. However, the particular isotype changes the function of the antibody and where it localizes in the body in vivo [see in vivo (Wiki link)].[1]


 * [Add section title about ‘Class Switching’]


 * [moved paragraph down] Immunoglobulin class switching can be used to change the class of the heavy chain, but not of the light chain that corresponds to a particular B cell. The B cell, during maturation, must choose to express either one of the light chains and sticks with that isotype for its lifetime.
 * [Describe class switching in a broad sense, because the 'Immunoglobulin class switching' link above is basically what this section is about]

Merger proposal
I propose that Isotype (immunology) be merged into Antibody. The latter seems to be more extensive and up-to-date. Either that, or the latter should point here, with only a short description appearing in Antibody. I suggest a merger both because the Antibody page is of a reasonable size, and because it is more likely to receive future attention over Isotype (immunology). Kwikwag (talk) 13:08, 11 February 2016 (UTC)

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