Talk:Kawasaki disease

Previous discussions without headers
Is anyone able to add a pathology section? The disease is explained and discussed but the underlying mechanism isn't mentioned.

The Treatment is repeated in the Prognosis. Suggest removing the final line from the prognosis section. Kilbosh 14:24, 4 April 2006 (UTC)

I clarified the prevalence of coronary artery aneurysms. Can someone show me how to reference the source? It is in Pediatr Infect Dis J. 2006 Mar;25(3):245-9. Pkoetters 05:48, 10 August 2006 (UTC)


 * Two aspects here - firstly if the item is a footnote (i.e. to verify or expand on a specific fact within the article, vs source for the whole article which would be a reference) need place it into a footnote section with forward and back links to relevant location in the text. There are several methods for this, latest being metawiki's cite.php system and described at WP:Footnotes that encloses a citation within   tags up in the text (and   in the Footnotes section to list out the items)
 * Hence at relevant point in text (after punctuation) insert:


 * Secondly is how to format the citation details themselves. Other than also needing authors and a title, this can be left as plain text as above, manually formated with single-quotes used to italicise the journal this = this, or bold the issue number that = that. Alternatively there are various citation templates to format and structure details for you, in this example we need a journal citation so see Template:cite journal.
 * Hence:
 * Gives:
 * So to combine footnotes and citation templates:   and under Footnotes section header rememember to have a  
 * Finally if you can locate on PubMed the article's abstract number, add an additional  id=PMID #######  parameter to create a link to it, e.g. . Very useful for all of this is Diberri's tool (http://diberri.dyndns.org/wikipedia/templates/) that takes a PubMed abstract number and autogenerates the cite journal template markup which can then be copied & pasted into wikipedia, e.g. see this example.


 * For your example, needs author(s) name and the paper's title, then is it a reference for the article as a whole, or a footnote to a specific statement. Please do feel free to ask any questions :-) David Ruben Talk 13:01, 10 August 2006 (UTC)
 * This article is full of technical jargon that the average reader cannot understand. —Preceding unsigned comment added by 64.198.82.59 (talk) 01:27, 5 February 2010 (UTC)

John Travolta's son had this disease and just died?
If I read this wiki entry correctly, only 2% of children die from this.

I'm wondering if in fact Jett died from this, did the fact that his parents are Scientologists (don't adhere to some modern medical treatments) have anything to do with his death. In other words, was he getting proper treatment? —Preceding unsigned comment added by 65.184.76.241 (talk) 21:53, 2 January 2009 (UTC)

Sorry this is now irrelevant, updated article explained that the death was due to a head injury sustained during a seizure.

I removed that section/sentence because he died from head injuries, not from the disease. NeoDeGenero (talk) 04:17, 3 January 2009 (UTC)


 * The page may need protection, or a blurb about the boy's death to be left up for, say, a week?sinneed (talk)

Jett Travolta son of John Travolta is hardly "famous", and is probably not even notable. It is certainly not clear that he died from Kawasaki Syndrome. Perhaps this section should be renamed, or deleted? AussieBoy (talk) 06:17, 4 January 2009 (UTC)

Can Kawasaki disease cause seizures? F W Nietzsche (talk) 09:04, 6 January 2009 (UTC) theoretically,KD (kawasaki disease),could cause febrile seizures,as persistant high fever is a hallmark of KD.However,jett had the disease at age 2,and the only known long term sequalae from KD is cardiovascular,so there is no reason to think that jett's death is in any way related to KD.Regards.Immunize (talk) 21:34, 17 January 2010 (UTC)

Yes, seizures are seen during the disease, but long-term effects or sequelae has not been determined. Children with Kawasaki syndrome do not continue to have seizures after the disease has resolved. Seizures are likely related to Jett's autism, as many parents of autistic children have noted he had autism. —Preceding unsigned comment added by 64.126.65.190 (talk) 03:35, 21 February 2011 (UTC)

Teachable moment
Now that Kawasaki disease is in the news, this page will get a lot of hits. It attracts vandalism, but it's also a teachable moment to educate people about Kawasaki disease.

It's a good educational opportunity, because autoimmune diseases, and specifically vasculitis, is a large class of important diseases with high incidence. Nbauman (talk) 06:24, 6 January 2009 (UTC)

Update for 'Causes' section
A recent international study has identified new genes that appear to affect susceptibility to Kawasaki disease. The study found that genes involved in cardiovascular function and inflammation may be particularly important and some seem to function together.

Reference: The article is in PLoS Genetics, an open-access journal, and is freely available online at http://www.plosgenetics.org/doi/pgen.1000319. Citation: Burgner D, Davila S, Breunis WB, Ng SB, Li Y, et al. (2009) A Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease. PLoS Genet 5(1): e1000319. doi:10.1371/journal.pgen.1000319  PMID: 19132087 Plosgenetics (talk) 16:18, 13 January 2009 (UTC)

refs 3 and 4
Whoever is working on this article - check refs 3 and 4 in the Presentation section - I removed some vandalism, but the refs themselves appeared to be valid sources for Kawasaki disease. I'm just not sure where you want to use them. — Ched ~ (yes?)/© 06:58, 15 March 2009 (UTC)

Category:Virus-related cutaneous conditions
I categorized this under Category:Virus-related cutaneous conditions under the rational from section Pathogenesis chapter 80:1232-4 from Dermatology Second edition from Bolognia, Jean L. ISBN 1-4160-2999-0. Calmer  Waters  20:25, 24 December 2009 (UTC)
 * Sounds great! ---kilbad (talk) 20:28, 24 December 2009 (UTC)
 * However, its already under Vascular cutaneous conditions Calmer   Waters  20:37, 24 December 2009 (UTC)
 * You can do both if you want. Your call... ---kilbad (talk) 20:38, 24 December 2009 (UTC)
 * Uggh. That one was killing me. Spent the last hour trying to pin it down only to find out it was already in one. Two it is. Thanks Calmer   Waters  20:44, 24 December 2009 (UTC)

Picture query (picture G)
On the grid of pictures picture G doesn't look like any way of giving BCG that I've seen (could be a Heaf test I suppose). 3x3 grids of needle pricks look like some form of a skin prick (allergy) test to me. Looks like it came from a journal but doesn't necesarily mean the right caption or correct picture made it into the article. Going to be awkward to photoshop it out though. Arfgab (talk) 14:07, 13 April 2010 (UTC)


 * You are right, I took the picture and the caption from the same article that I am citing. I think that this mistake was published in the paper too, if it is a mistake in the first place. But as you said, I ve never seen a smiler BCG vaccination, so what do you think should be done here?? M aen K. A.  Talk  15:08, 13 April 2010 (UTC)
 * I guess the only thing would be to e-mail the author for clarification. It is Korean and I've never worked there so they may do things differently. Arfgab (talk) 19:59, 13 April 2010 (UTC)
 * Not sure why there are 2 grids on this picture but take a look at the picture around Bacillus_Calmette-Guérin and see if you think that looks familiar. (Apologies to Dr Kim) Arfgab (talk) 20:03, 13 April 2010 (UTC)

Overall, about 2% of patients die from complications of coronary vasculitis
This line is misleading for the prognosis of kawasaki disease. Though this disease is a type of coronary vasculitis, coronary vasculitis isn't exclusively kawasaki disease. If it is meant to be representative of kawasaki disease then the 2% quoted is most likely a SMR, or standard mortality ratio, that quantifies an increase in mortality relative to the general population. For instance, in "Sudden Death in an Infant Revealing Atypical Kawasaki Disease" the mortality rate caused by KD is 2.8% higher than the general population. The Merck Manual quotes 0.17% mortality rate with adequate therapy in the United States. — Preceding unsigned comment added by Kimqcat (talk • contribs) 04:09, 1 July 2013 (UTC)

Causes
The article as it is now states that we should call it Kawasaki Syndrome, in the causes section. The reasons given for this are that the cause is not known. However, immediately after this statement, the article resumes calling it Kawasaki Disease. Is this an issue, and if so, is there a way to correct it? — Preceding unsigned comment added by 174.20.189.191 (talk) 15:02, 18 October 2013 (UTC)

Structure in "Signs & Symptoms"
The first couple of sentences here could be reworded to be clearer. Also the wiki link from "remittent" goes to the article "Fever". I made an attempt at fixing the latter and then realised I'd misinterpreted the sentence. Will try to remember to revisit but writing here in case I don't. Dichohecho (talk) 12:15, 15 September 2016 (UTC)

Scientific statement
10.1161/CIR.0000000000000484 JFW &#124; T@lk  08:28, 25 April 2017 (UTC)

A Commons file used on this page or its Wikidata item has been nominated for deletion
The following Wikimedia Commons file used on this page or its Wikidata item has been nominated for deletion: Participate in the deletion discussion at the. —Community Tech bot (talk) 13:22, 3 May 2020 (UTC)
 * Kawasaki symptoms B.jpg

Definition
This is the definition provided at the start of the main text of the current AHA guidelines: "Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause that predominantly affects children <5 years of age." I believe we need to go with something along those lines at the start of the lead that highlight the paediatric context – especially for the benefit of casual readers, including ones coming rapidly to this page following current newspaper reports regarding unusual COVID manifestations in some infants. 86.134.212.26 (talk) 14:09, 8 May 2020 (UTC) Adding: The definition in our frequently used PubMed Health source also immediately highlights the paediatric context: "Kawasaki (KAH-wah-SAH-ke) disease is a rare childhood disease. It's a form of a condition called vasculitis..." 86.134.212.26 (talk) 15:33, 8 May 2020 (UTC)
 * Okay simplified a bit to "is a disease of unknown cause that results in a fever and mainly affects children under 5 years of age" thoughts? Doc James  (talk · contribs · email) 02:23, 9 May 2020 (UTC)
 * Ok, though I believe the clear-cut 'vasculitis' definition (per PubMed Health ) also needs to be close to the top, as it was before (rather than trailing speculation regarding the mechanism). Will switch that one back . 86.134.212.26 (talk) 12:15, 9 May 2020 (UTC)
 * Sure, moved some of the less common symptoms out of the lead. Doc James  (talk · contribs · email) 08:16, 10 May 2020 (UTC)
 * Agree, and looking good, imo :-) 86.134.212.26 (talk) 09:54, 10 May 2020 (UTC)

COVID-19
At present we have a summary at the foot of == History == of the ongoing open questions regarding Kawasaki-like presentations. Imo, that's appropriate, whereas (per WP:RECENT, whereas news-style (local/global) updates would not be on this page about a particular clinical entity (example). Clearly, per WP:MEDRS, it would be premature to insert speculative/primary-sourced content in clinical sections (e.g. == Causes ==). A little like User:KalanK10 (I think) however, I have been wondering whether some brief mention of the issue should be made at the foot of the lead, as that might be what general readers would expect. Personally, I feel something of the sort  may be appropriate.  86.134.212.26 (talk) 10:28, 10 May 2020 (UTC)


 * See also newly created page Paediatric multisystem inflammatory syndrome. 86.134.212.26 (talk) 17:25, 10 May 2020 (UTC)

Signs and symptoms
Under this section there are pictures of symptoms, but they are not stated except by a letter. Can someone more knowledgeable than I am please label these symptoms by the letter in order to clarify the symptom pictured.

Moving here
We mention PMIS both in the infobox under differential and in the second paragraph. We do not also need a banner at the top of the article.

Doc James (talk · contribs · email) 05:55, 14 May 2020 (UTC)
 * Didn't see it in the infobox, apologies. Was hoping the hat note would spur editors to update the PIMS page instead of this one and a few others. If you get a chance could you give the multisystem inflammatory syndrome disambiguation a look over to see if it is clear enough? Best, Classicwiki (talk) If you reply here, please ping me. 16:33, 14 May 2020 (UTC)

moved content
@User:Doricke: The content added here is sourced to a (possibly still not peer-reviewed) hypothesis-type paper which does not comply with WP:MEDRS: "A novel hypothesis that Kawasaki disease is caused by dysregulated activation of mast cells by Fc receptor-bound pathogen antibodies accounts for much of the pathology of this disease . Histamine release from mast cells induces contraction of pericyte or effector cells on cardiac capillaries impeding blood flow . Back pressure from capilaries occulsions induces coronary aneurysms in some patients .  Other Kawasaki disease symptoms can be linked to increased histamine levels." 86.186.155.159 (talk) 08:44, 12 June 2020 (UTC)

moved content
From diff (apparently following on from earlier addition of analagous content by Doricke, a SPA whose user name virtually coincides with that of the first author of this hypothesis-type paper): "The hypothesis has been put forward that Kawasaki Disease is caused by antibody activation of mast cells." 86.186.155.159 (talk) 08:38, 24 July 2020 (UTC)

Some current MEDRS
(some *selected* recent potential medrs etc, as of June 2020; not all actually cited):

Guidelines / Consensus statements:











 * [current]

Books



 * [no open-access]

General














Systematic reviews / meta-analysis








Other







 * />

- Research:







Causes, pathogenesis, epidemiology, etc







 * *Not* open-access


 * *Not* open-access



Role of immunization



 * *Not* open-access

Recent SCIRS for History


86.186.155.159 (talk) 12:24, 15 June 2020 (UTC)