Talk:Ketotifen

2nd generation?
Is it really second generation? That would imply its non-sedating, but a lot of people report it is sedating. Danski14(talk) 17:35, 10 June 2023 (UTC)


 * I addressed this issue, thank you! See the updated article. Maxim Masiutin (talk) 21:51, 16 November 2023 (UTC)

Hanks v. Hubbard
Can you please review the section Ketotifen, whether the case was presented correctly? Maxim Masiutin (talk) 19:24, 12 November 2023 (UTC)

Missing citations
The lead in medical articles should have citations. Readers should not have to search for relevant text or relevant citations within the article. Please see discussions about citations at WT:MED, WP:MEDMOS, WP:MEDRS, and WP:MEDCITE. -- Whywhenwhohow (talk) 05:49, 3 February 2024 (UTC)


 * The current rules do not mandate that the lead in medical articles must have citations, this is a duplicate discussion at Talk:Modafinil. You argument "Readers should not have to search for relevant text or relevant citations within the article" equally applies to all Wikipedia articles where the lead may have no reference. Even if the rules mention that medical articles may have higher citation density, they do not mandate it. Maxim Masiutin (talk) 17:53, 4 February 2024 (UTC)

Metabolized by cytochrome P450 enzymes?
I checked out the DrugBank page cited and the only section of its contents that suggests the involvement of CYP enzymes is the "Predicted ADMET Features" selection. I'm having trouble finding actual literature that corroborates this role for CYP enzymes in ketotifen's metabolism. Moreover, the aforementioned section of the site seems to only suggest, at most, that ketotifen is a CYP3A4 substrate and a CYP2D6 inhibitor rather than both a CYP3A4 and CYP2D6 substrate. Is there something I'm missing? Thank you. Berrrrrd (talk) 23:06, 13 February 2024 (UTC)


 * Thank you, I've added a reference to a review that support the claim that ketotifen is mainly metabolized by CYP3A4 and CYP2D6. I also added 3 secondary sources that claim that ketotifen, like other antihistamines, is metabolized is mainly metabolized by CYP3A4 and CYP2D6. Please let me know whether it is OK.
 * Are you willing to do a Good Article review for Ketotifen? Maxim Masiutin (talk) 10:19, 14 February 2024 (UTC)
 * Please let me know whether this citation, makes sense, as well as the other citations that group ketotifen with other histamines in the discussion on how they are metabolized. Maxim Masiutin (talk) 14:09, 14 February 2024 (UTC)
 * So for sake of full disclosure, I'm not a pharmacologist, just a layman that happens to be on a rather high dose of ketotifen, and, as such, am rather interested in the interaction potential ketotifen could posses--particularly in the event it were a substrate of CYP2D6. It'd probably make sense for a pharmacologist to review this page rather than me. That said, I'm not seeing where specifically refers to ketotifen being metabolized by CYP. For citation 34, I do notice the selection that specifies ″At this time fexofenadine and ceterizine -- derived from hydroxyzine -- are the two antihistamines that are not metabolized by CYP (Simpson and Jarvis, 2000)″, though, it doesn't specify what ketotifen is metabolized by. For citation 35 , ketotifen's subheading seems to be alongside various other medications where relevant CYP enzymes are specified, but ketotifen seems to be an exception in this regard. Citation 36  *does* specify ″As has also been extensively documented in other articles of this same issue, all the first generation antihistamines, and many of the second generation drugs (ketotifen, loratadine, ebastine, mizolastine, rupatadine), undergo total or partial liver metabolization through isoenzymes of the cytochrome P450 system (CYP3A4, CYP2D6).″ Citation 3 of that same paper  seems to repeat the same claim (though characterizing ketotifen as a first generation antihistamine, rather than a second generation), but I can't seem to find papers that specifically review pharmacokinetics and make this claim. We seem to, at best, have this claim being made in passing in papers that are broader or have different focuses entirely. Again, a pharmacologist reviewing this article rather than a layman like me might be a good idea. Berrrrrd (talk) 17:55, 14 February 2024 (UTC)
 * Sorry, I meant, not . Indeed does not explicitly mentions ketotifen apart from the fact that it mentions it as an ophtalmic solution.
 * The article mentions: As has also been extensively documented in other articles of this same issue, all the first generation antihistamines, and many of the second generation drugs (ketotifen, loratadine, ebastine, mizolastine, rupatadine), undergo total or partial liver metabolization through isoenzymes of the cytochrome P450 system (CYP3A4, CYP2D6). Maxim Masiutin (talk) 18:08, 14 February 2024 (UTC)
 * I only kept references to CYP3A4, and removed that to CYP2D6 because they were not explicitly specified for ketotifen. I put additional sources. Thank you again for pointing that out! Maxim Masiutin (talk) 19:01, 14 February 2024 (UTC)

Citations in the lead
Hello, @Femke, can you please help. My understanding is that citations in the lead are not mandatory if the lead repeats the claims made in the body of the article where such claims are properly sourced. This rule also applies for medical articles. I need your opinion because @Whywhenwhohow in the edit 1212823166|1212703519 mentioned that there are "no medical citations in the lead" and put a warning box, however, I intentionally didn't put medical references to the lead for it to be easier to understand. Don't you think that medical articles are no exception when there can be no references in the lead? Maxim Masiutin (talk) 04:05, 10 March 2024 (UTC)


 * If you look at policy and guidelines, I'm unaware of anything that says we should have citations. Many features articles do not have them: lung cancer, dementia with Lewy bodies. Therefore, articles should not be tagged. That said,  the leads of medical articles are often translated, which does make for an argument that lead citations are valuable in these articles. —Femke 🐦 (talk) 07:27, 10 March 2024 (UTC)
 * Thank you, Femke! I will use these links that you gave to FA as a reference, I will put them into the comments block. Maxim Masiutin (talk) 10:07, 10 March 2024 (UTC)


 * I started a discussion at WT:MED --Whywhenwhohow (talk) 17:17, 10 March 2024 (UTC)

Ketotifen
This subsection is transcluded from Teahouse.
 * The following is an archived discussion concerning one or more templates or modules. Please do not modify it. Subsequent comments should be made on the appropriate discussion page (such as the template's talk page or in a deletion review).


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