Talk:Kidney transplantation

Rewrite
This needs a big rewrite, if nobody minds, I will do after I have finished with dialysis (and renal failure etc etc)Felix-felix 14:55, 2 February 2006 (UTC)

Michael Woodruff
The article on Michael Woodruff, a kidney transplant pioneer is undergoing peer review. Please participate at Peer review/Michael Woodruff/archive1.

Rewrite
I'm working on a rewrite.

Longest lived kidney transplant receiver
I see there are two nominees included for the category:


 * 1) Australian Aboriginal activist Charles Perkins, is the longest surviving receiver of a kidney transplant, living twenty-eight years on his donor organ.[citation needed]
 * 2) Denice Lombard of Washington, D.C., received her father's kidney on August 30, 1967 aged 13 and is still alive and healthy thirty-nine years later.

However, the record is more. Johanna Leanora Rempel (née Nightingale, b. Mar. 24, 1948) of Red Deer, Alberta, Canada, received a kidney transplant from her identical twin sister Lana Blatz, on Dec. 28, 1960 at the Peter Bent Brigham Hospital in Boston, Massachusetts, USA. I last saw the category in Guinness 2004 (published Aug./Sept. 2003), so she had likely lived with the transplant for some 42 years by then. You can find a reference here (citing Guinness 2003). --Anshelm &#39;77 19:35, 26 April 2007 (UTC)

Dr. Earl Carlson passed away on Friday, June 12, 2009 at the age of 57. The kidney he received from his Uncle Jerry Carlson at age 17 was still functioning until the end. He survived almost 40 years with the transplant.

Chains
I recently read about donation chains (or some similar phrase) whereby two (or more) donors/recipients exchange kidneys. For example recipient A has an incompatible volunteer B who donates (instead) to C in exchange for a compatible kidney provided D who donates on C's behalf. Properly sourced, this might make an interesting addition to the article. Rklawton (talk) 23:11, 3 February 2009 (UTC)
 * There's started to be more paired (or pooled) kidney donation. Some people have done it in a chain where others are encouraged to donate, but that's more of an ideal whereas paired donation might begin to be used more often IMHO.  Well worth adding if it isn't there.:) Sticky Parkin

Vaginal Donation
This is the most important advancement in kidney transplantation in the past several years. If the expanded section is inappropriate for encyclopedic content, I'd suggest integrating it into the rest of the article. However, the vaginal donation performed by the doctors at Johns Hopkins is extremely important and relevant as a current event and as an important case in the history of kidney transplantation —Preceding unsigned comment added by For the Laugh of God (talk • contribs)


 * I really disagree. Vaginal donation would only be an option if the donor has been hysterectomised, which is (hopefully) in the minority. It sounds groovy, but it is too rare to be discussed in so much detail. There have been vaginal splenectomies, so this is certainly not the first transvaginal abdominal procedure!
 * Please try to form consenseus first before reinserting your content! JFW | T@lk  00:00, 8 February 2009 (UTC)
 * I've added it as it is encyclopedic, it has been in respectable WP:RS, such as being reported by the BBC. I like to think I put it in perspective in the article and didn't give it WP:UNDUE, but compared it to Single port laparoscopy, which hopefully will be able to be used on more people than the vaginal technique:)  Thanks for pointing out the woman had a previous hysterectomy. Sticky Parkin 02:45, 9 March 2009 (UTC)

Some stats for table
http://www.anzdata.org.au/v1/report_2009.html see chapter 8

In 2008, in Australia, there were a total of 813 kidney transplants performed, 459 cadaveric donations and 354 live. In the same year, in New Zealand, there were 122 kindey transplants, 53 cadaveric and 69 live. Lucy1958 (talk) 08:56, 24 February 2010 (UTC)

1911 kidney transplant reported in NY Times
A Nov. 14, 1911 article in the NY Times (dateline Nov. 13), "Dr. Hammond Gives Patient New Kidney," describes a 1911 kidney transplant. I stumbled on this while searching for Triangle Shirtwaist articles (juxtaposed to the transplant article). This story seems unlikely, but I am surprised to find no Web reference to this 99-year-old claim anywhere--not even Wikipedia. I hope to remain blithely ignorant of renal function in my lifetime, but maybe one of you more-interested people (who probably and unfortunately have too much time in dialysis clinics, I'm guessing) can figure out how to fit this into the article. I do hope these people died relatively quickly; I'm less worried about the guy with the dog kidney in this regard--if any of it is true. Using Google's Timeline view for kidney transplant, I see that there was also a 1936 transplant in Russia and both of these transplants are mentioned in Susan Lederer's 2008 book, Flesh and blood: organ transplantation and blood transfusion in Twentieth Century America. Danaxtell (talk) 02:00, 19 April 2010 (UTC)

1933-34 transplant attempt
There is a 1933 bureau article in a newspaper about a Worony, professor in blood transfusion, of Kiev University conducting a kidney transplant from a recently dead man to a young woman. Consulting the wiki Organ_Transplant's history reveals this to be a "Yuri Voronoy". Searching the internet for Worony finds a single reference to two failed attempts. Page 10 & 11 of this PDF: http://www-foreign.univer.kharkov.ua/ua/nauka/konf/on-line_2012.pdf

1934 wurde zum ersten Mal in der Welt eine Verpflanzung von Niere durch den sowjetischen Chirurgen Worony für eine Frau von 26 Jahren gemacht, die infolge einer Vergiftung durch Sublimat irreversible Veränderungen in der Niere erlitt. Die Operation missglückte, die Kranke starb. Die nächsten klinischen Operationen missglückten ebenfalls, weil die verpflanzten Nieren schnell starben.

The preceding paragraph discusses a French surgeon:

Der Mensch, dem ein Organ oder das Gewebe zur Verpflanzung entnommen werden, wird Spender genannt und der Organismus, der sie aufnimmt, wird Rezipient genannt. Eine wissenschaftliche Realisierung von diesem Gedanken war 1905 vom französischen Chirurgen A. Karrel vorgenommen. In einem Experiment wurde die Leber eines Hundes transplantiert. Nach dem ersten erfolgreichen Experiment verbreitete sich diese Operation sehr schnell in allen Ländern der Welt.

Also see this reference to Voronoy's 1933 operation, fetched from the wiki article on Organ Transplant. http://onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2009.00986.x/abstract

--Krekling (talk) 11:36, 28 August 2013 (UTC)

Erroneous picture
In the only figure featured in this article, captions linked with the great vessels of abdomen have been misplaced. Aorta (called here 'artery', white) should be on the left side of the body, and inferior vena cava ('vein', grey) should run on the right. Lb.at.wiki (talk) 08:39, 3 August 2010 (UTC)


 * You're absolutely right. The correct labelling can be seen in the scan from Gray's Anatomy on the right.  The errant image comes from this page of the National Institute of Diabetes and Digestive and Kidney Diseases, so the original error is theirs, not Wikipedia's!  Given the image is used in three different articles the best course of action would be for someone to upload a modified version of the figure with the labels edited.  I don't have time to do that myself right now, but I've left a message at Wikipedia talk:WikiProject Medicine. Adrian J. Hunter(talk•contribs) 14:58, 3 August 2010 (UTC)


 * I've replaced the image with a new version with larger labels and with "artery" and "vein" labelled correctly. I stuck with simple labels rather than "aorta" and "inferior vena cava", as the medical terms would introduce complexity unnecessary to the purpose of this image.  It was noted in a now-archived discussion at Wikiproject Medicine that it ought to be possible to find or create a better image.  Adrian J. Hunter(talk•contribs) 13:06, 8 September 2010 (UTC)

Clarifications in Living Donation section
In the U.S. only the surgeon performing the procedure can obtain Informed Consent. The psychological evaluation is performed by a social worker or other mental health professional. They cannot legally obtain Informed Consent. Their job is detect coercion and issue a strong warning against 'valuable consideration' (eg. payment) for the proffered kidney.

In addition, there is great variance in the living donor evaluation process and the information presented during the Informed Consent process. Housawi's study revelaed (among other things) that 52% of transplant professionals do not disclose the possibility of long-term cardiac problems with prospective living donors even though reduced kidney function is highly correlated with an increased risk of hypertension and other cardiac difficulties (Emera).

This article's statement that evaluation prevents bad outcomes is disingenuous and erroneous when Cherikh admits that 200 living kidney donors have registered on the waitlist in need of their own transplant since 1994, and Azar's study indicated a total living donor complication rate of 55.6% and serious complication rate of 5.8%

Housawi, A.A. Transplant Professionals Vary in the Long-Term Medical Risks They Communicate to Potential Living Kidney Donors: an international survey. Nephrol Dial Transplant (2007) 22: 3040–3045.

Emara M, Ragheb A, Hassan A, Shoker A. Evidence for a need to mandate kidney transplant living donor registries. Clin Transplant 2008: 22: 525–531.

Cherikh WS, Pan-Yen F, Taranto SE, et al: Prior living kidney donors who were subsequently placed on the waiting list: An updated OPTN Analysis. 2008 American Transplant Congress (ATC), May 31 to June 04, 2008, Toronto, Ontario, Canada.

Azar SA, et al. Is living kidney donation really safe? Transplant Proc. 2007 May;39(4):822-3. 24.93.173.153 (talk) 21:22, 6 November 2010 (UTC)

Dr Richard H Lawler
In a number of quizzes I have heard Dr Lawler being credited as the one who carried out that pioneering 1950 surgery referred to in the article. Why doesn't he get a mention for this anywhere in Wikipedia? Why isn't anyone credited in the article with that operation? Gmackematix (talk) 14:00, 20 July 2011 (UTC) I'm probably not referencing these the way I should, but here are links to the New York Times, Guinness Book of Records and a specialist work, all saying Dr Lawler was first to carry out a human kidney transplant but he doesn't even get a mention here let alone have his own article. Even if he has been discredited surely something should be said somewhere? http://www.nytimes.com/1982/07/27/obituaries/rh-lawler-pioneer-of-kidney-transplants.html http://www.guinnessworldrecords.com/search/Details/First-successful-kidney-transplant/48443.htm http://books.google.co.uk/books?id=t6VBKdoaU7IC&pg=PA5&lpg=PA5&dq=Kidney+Transplant+Lawler&source=bl&ots=zXr3K_F83w&sig=JKi6mys_Vb9BupvnM3EnsB6wsoE&hl=en&ei=2eAmTqXQIIXChAedtvn-CQ&sa=X&oi=book_result&ct=result&resnum=6&ved=0CDsQ6AEwBQ#v=onepage&q=Kidney%20Transplant%20Lawler&f=false Gmackematix (talk) 14:13, 20 July 2011 (UTC)

Live graft donor versus deceased donor
Under the live donation section, this article states that live graft donation works better than deceased graft donations and cites source #11. The article cited under #11 does not mention any comparison of live versus cadaveric donation. — Preceding unsigned comment added by Isaac siemens (talk • contribs) 21:43, 18 November 2011 (UTC)
 * Thanks for the note. I've replaced the source. Adrian J. Hunter(talk•contribs) 03:43, 19 November 2011 (UTC)

Long-term complications
Br Med Bull JFW &#124; T@lk  20:31, 12 June 2013 (UTC)

BK Virus (Polyomavirus)
It is worth noting information about BK Virus (Polyomavirus) since it's an area of study that doctors / consultants are well aware of. Polyomavirus / increase of serum levels in a transplanted patient can be mistaken for acute rejection, leading to the wrong treatment being administered. Primary treatment for rejection is to increase immunosuppressants, which is well documented. In Polyomavirus, treatment consists of lowering/stopping dosage of immunosuppressants such as Tacrolimus, Azathioprine, and introducing Leflunomide. Increase in immunosuppressants; in cases of Polyomavirus / BK nephropathy only causes further damage and risk of graft loss due to allowing the intensification of BK virus load. — Preceding unsigned comment added by F Nikk (talk • contribs) 13:51, 5 November 2014 (UTC)

Moved here
I really enjoyed your article. Here is a link I think you will find helpful regarding Kidney transplant and living donations. Living Donations. Here is another article from St. Michael's Hospital regarding renal transplants. Renal Transplants --Amaddalena (talk) 16:24, 14 October 2014 (UTC)Amanda Maddalena

List of people in Statistics section
Do we really need the largely unsourced list of people? I'd remove it myself, but thought I'd get a second opinion here first. Valenciano (talk) 21:50, 13 March 2015 (UTC)

I think if people are happy to be included in the stats, especially long surviving transplants, it can be positive in that it may give hope to people who need transplants; it can also motivate people to become organ donors. I update my info every year on my anniversary. [Annemarie Grosskopf] — Preceding unsigned comment added by 196.14.20.83 (talk) 07:45, 3 November 2016 (UTC)


 * yes, i concur, and its policy to remove any unsourced material on living persons immediately, no second opinion that area necessary. thanks for being considerate though. here is the info for people to research:


 * Carol Posner of Torrance, California, received a kidney from a deceased donor on March 15, 1975 at age 20, is active, healthy and celebrating her 40th anniversary on March 15, 2015
 * Katheryn Aiton of Grand Rapids, Minnesota, received her brother's kidney on June 15, 1965 at age 28. Her brother is now 80, she is 77, both healthy and active. 50 year anniversary celebration to be held in June 2015.
 * Thomas Thein of Clara City, Minnesota and a recent college graduate, received a kidney from his older brother, Anthony Thein, at the University of Minnesota on January 4, 1967.  I n 1967 their parents (John and Rose Thein) had absolute faith that the transplant would work and both sons would live long, productive and happy lives.  They were right. Tom married one of his nurses (Peggy), had three children and was a co-owner of a family business until retirement. Tom and his wife are, as of January 4, 2015, enjoying retirement.  Tony is, as of January 4, 2015, also doing well, a retired college music professor living in Minneapolis, Minnesota.
 * Denice Lombard of Washington, D.C., received her father's kidney on August 30, 1967, at age 13 and is still alive and healthy 45 years, 9 months later as of 5-5-13. Her father will turn 85 in October and is still healthy and active.
 * Mary Griffiths, at 18 years of age, received a kidney from a living donor(mother)Pat Davis January 7, 1981 transplant surgeon Allan C. Birch. She is still using conventional anti-rejection medicines, with good results.
 * Robert Brice of Adelaide, South Australia received a cadaver kidney in September 1981 at the age of 42 and is alive and healthy in May 2015 33 years after receiving the transplant from the victim of a horse riding accident.
 * John Dan of Nairobi, Kenya, was the known longest-surviving kidney recipient in East Africa. He received a kidney from his brother in 1984 and lived for 27 years.
 * Chakravarthy from Chennai, India, received kidney from his brother on 2 May 1983 at the age of 29, is still alive and healthy 27 years later.
 * Annemarie Grosskopf of Cape Town, South Africa, received a kidney from a deceased donor in Johannesburg on 3 November 1981 at the age of 21, and she and her son, who was born 9½ years after the transplant, are both in good health 36 years later.

even with sources, the material needs a rewrite to remove "celebrating" etc. WHYYY??? Mercurywoodrose (talk) 16:28, 6 June 2015 (UTC)

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Unsourced biographics
The following two claims were unsourced and I am therefore moving them here pending confirmatory sourcing:
 * Robert Brice of Adelaide, South Australia received a cadaver kidney from the victim of a horse riding accident in September 1981 at the age of 42 and is alive and healthy in April 2016
 * Annemarie Grosskopf of Cape Town, South Africa, received a kidney from a non-related donor in Johannesburg on 3 November 1981, and she and her son, who was born 9½ years after the transplant, are both in good health 35 years later.

Thanks. JFW &#124; T@lk  11:31, 4 April 2016 (UTC)

External links modified
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Preserving graft function
10.1016/S0140-6736(17)31283-7 JFW &#124; T@lk  08:20, 28 May 2017 (UTC)

Notable recipients list
I think it's a bit misleading to indicate "survival" longevity for all of these when an individual's death may not be directly related to the transplant. For example, according to her Wikipedia article, Natalie Cole died from a heart condition diagnosed after her transplant - but it's not given a direct link - and drug use was also cited as a factor. The list should also be updated to add Selena Gomez. 136.159.160.4 (talk) 14:50, 14 September 2017 (UTC)

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Missing link to nephrectomy?
This page seems recipient-focused, even though it does discuss endoscopic/vagina donor removal methods.

Shouldn't there at least be a link to Wikipedia's entry for Nephrectomy?

ICD 10 PCS link in infobox is wrong
Infobox medical intervention has value of ICD10       = {{ICD10PCS|OTY|0/T/Y but the link is dead. https://www.icd10data.com/ICD10PCS/Codes/0/T/Y/OTY

It is not clear how to edit that on Wikidata.EncycloABC (talk) 19:07, 31 May 2019 (UTC)

Risk factors for rejection
10.2215/CJN.05560519 JFW &#124; T@lk  22:07, 7 November 2019 (UTC)

Wiki Education assignment: Research Process and Methodology - SP24 - Sect 201 - Thu
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