Talk:Koller's sickle

Untitled
Hello! I am considering working on developing this page for an educational assignment in Fall 2013. I was wondering if anyone else is working on the page as well? Please message me if you are, so that we don't end up duplicating efforts in developing the page Allielew00 (talk) 20:56, 6 October 2013 (UTC)

The definition of Koller's sickle could be expanded upon to provide more information about avian gastrulation. A more complete description Koller's sickle's involvement in the process, and how it contributes to the overall gastrulation process could allow for more clarity on the topic. Also, a more expanded explanation of the primitive streak could be beneficial for providing a more in-depth overview of Koller's sickle and its role in avian gastrulation. Allielew00 (talk) 21:57, 6 October 2013 (UTC)

T1d7 (talk) 19:54, 7 October 2013 (UTC), Allielew00 (talk) 19:55, 7 October 2013 (UTC), Blairwal (talk) 19:57, 7 October 2013 (UTC)

Bibliography of Sources Used for Development of Page
Callebaut, M., Van Nueten, E., Bortier, H. and Harrisson, F. (2003), Competitive inhibition by Rauber's sickle of the primitive streak and/or (pre)neural plate inducing effects of sickle endoblast in avian blastoderms. J. Morphol., 257: 364–374. doi: 10.1002/jmor.10123

Callebaut, M., Van Nueten, E., Bortier, H. and Harrisson, F. (2003), Positional information by rauber's sickle and a new look at the mechanisms of primitive streak initiation in avian blastoderms. J. Morphol., 255: 315–327. doi: 10.1002/jmor.10065

Carlson, Bruce M. Human Embryology & Developmental Biology. St. Louis: Mosby, 1999. Print.

Gilbert SF. Developmental Biology. 10th edition. Sunderland (MA): Sinauer Associates; 2014. Early Development in Birds. Print.

Society for Developmental Biology. "Developmental Biology." Symposium of the Society for Developmental Biology (1959): n. pag. Print.

Vasiev B, Balter A, Chaplain M, Glazier JA, Weijer CJ. Modeling gastrulation in the chick embryo: formation of the primitive streak. PLoS One. 2010;5:e10571.

Allielew00 (talk) 23:37, 14 October 2013 (UTC) T1d7 (talk) 01:58, 15 October 2013 (UTC) Blairwal (talk) 16:49, 15 October 2013 (UTC)

Summary of Plan for Development of Page
We will begin with a discussion of what cell processes initiate the local thickening of cells, which is known as Koller's sickle. We will elaborate on what an avian blastoderm and hypoblasts are, so that the article is more easily understandable to the general population. We would also like to discuss why the sheets of cells are migrating anteriorly, and therefore why Koller's sickle is necessary in avian blastoderms. We will also add a more in depth explanation of primitive streak and how it is related to Koller's sickle. Blairwal (talk) 00:41, 19 October 2013 (UTC) Allielew00 (talk) 00:44, 19 October 2013 (UTC) T1d7 (talk) 01:50, 19 October 2013 (UTC)

Article Review
This article is off to a great start. I think will a few more edits it can improve even more. I would recommend extending each section of the article because it seems to still be missing information for each point. For the introduction, I would suggest mentioning the mechanisms that lead to koller's sickle formation and any specific signal pathways that might influence its development. I would link some more terms that might be important when discussing this topic such as area opcaca endoderm and endoblast. For the next section, I would suggest combining the next two paragraphs and then expanding upon the mechanisms of signaling for the posterior marginal zone formation. I think it can provide more of a background understanding as to how it is initiated to understand the consequences of its effects. I also think the two paragraphs are so closely related that it would seem to flow more and be less repetitive if you combined them. You could possibly rename the paragraph heading as primitive streak formation through PMZ, or something along those lines. For the next paragraph, I would recommend extending the information on that as well. I think taking the genes a step further and possibly providing a clinical relevance of a possible disease or effect of a mutation of the genes would be interesting. For the final paragraph, I would move it's position and place it after the introduction. I think historical facts about the discovery can be a nice addition for background information in the beginning of the article before the readers dive into more specific information. Also I think also expanding more about the experimenters studies and methods for discovering koller's sickle would be helpful. Also mentioning the relevance of such a discovery for science today would be informative to readers to know how far we have come and how much more there is to learn. I hope all of my comments were useful and good luck with any edits you choose to make! Ran21 (talk) 17:24, 22 November 2013 (UTC)

Peer Review

 *  Introduction 
 * “Koller's sickle is a local thickening of cells at the posterior edge of the area pellucida, specifically the upper layer, which is called the epiblast.” The opening line is correct grammatically, but the structure of the sentence with the specification allows for a bit of confusion if the upper layer is called the epiblast of if the posterior edge is called the epiblast. Also for the opening line of a detailed article, it would be helpful to have more context from the start on what Koller Sickle is in the first sentence. Mentioning avrian development earlier would help the reader who wants to know within the first sentence.
 * The last sentence of the paragraph “This happens in avian gastrulation, a process by which developing cells in an avian embryo move relative to one another in order to form the three germ layers (endoderm, mesoderm, and ectoderm).[1]” allows for the reader to understand a more general context at the end of the introduction. Maybe if this sentence was in a different place in the paragraph it would be easier to understand the mechanism.
 * Overall the introduction goes very in depth on the actual mechanism of the Koller’s Sickle. It would be hard to understand this paragraph without the experience of university level development and cellular courses. I understand that this is a detailed mechanism, and that detail must be given within the article, but a suggestion would be to try to make the introduction as easy for the general public to understand as possible.
 * Role of posterior marginal zone
 * “Cells in some marginal zones, like the PMZ, are key to development and cell fate determination in chick embryos.” The use of the word ‘some’ is ambiguous. Is this other marginal zones as well or is this other posterior marginal zones in organisms?
 * “Sheets of cells that form and grow anteriorly from Koller's sickle form the complete hypoblast layer of the chick blastoderm by combining with hypoblast islands.” Grammatically this is a long sentence that uses the verb ‘form’ twice. Breaking it up into two sentences or using a different word would make this sentence smoother.
 * Formation of the primitive streak
 * “Avian gastrulation occurs though the primitive streak.” Primitive streak is not a process, but rather a stage of development. It would be helpful to clarify that the primitive streak is not a processes, but that the avaian gastrulation occurs through the development or formation of a primitive streak.
 * “This is due to expression of different mesodermal marker genes among the cells located in different areas of Koller’s sickle.” I assume that the word ‘this’ is referencing the different movement of the cells, but a specification on the word ‘this’ would clarify the paragraph.
 * “The movement is coordinated by a Wnt planar cell polarity pathway which is activated by fibroblast growth factors from the hypoblast” A link could be added to the Wnt signaling pathway page.
 * “The movement is coordinated by a Wnt planar cell polarity pathway which is activated by fibroblast growth factors from the hypoblast” Fibroblast growth factors should be linked.
 * “The movement is coordinated by a Wnt planar cell polarity pathway which is activated by fibroblast growth factors from the hypoblast” neural plate should be linked.
 * Gene influence
 * ”cHex is also involved with the formation of the hypoblast, the endoderm in an anterior arc that overlaps the cardiogenic region, pharyngeal endoderm immediately adjacent to the forming myocardium, in the endocardium, and in the liver and thyroid gland primordial” This sentence structure is incorrectly formatted for a list.
 * ”In general, the goosecoid gene is thought to be involved in the development of the chicken organizer during gastrulation” Is the structure called the chicken organizer or is it supposed to be the chicken’s organizer? It could be fine as is, but only if the structure is called the chicken organizer.
 * Discovery
 * “The cell movements reminded him of a dance called the Polonaise, where dancers moved in parallel lines and would move from the back of the group to the center.” The use of the word ‘where’ is incorrect. ‘Where’ indicates a place. Instead the use of ‘in which’ would be a suitable replacement.

Overall Suggestions I thought the article was very insightful and well put together. I was wondering if there is any link of Koller’s sickle to human developmental biology. If there is a link to human development it would be very interesting, and maybe would provide a more relatable context or section to your article for the lay reader. I also know that there is not a vast amount of common articles concerning Koller’s sickle, but you may want to bolster the page with more articles from ‘non-scholarly’ sources. Along this same vein, much of the solid information is from the Developmental Biology textbook which is a single source that is not ewaly obtained by the public. Wildcator (talk) 02:23, 23 November 2013 (UTC)

Peer Review
I think the article had a lot of great information in it but I think the most important thing to work on is organization of the material and the overall flow of the article. It seems very choppy as it is. The introduction could be much more generalized, whereas right now it has a lot of very detailed information in it and it is hard to see the big picture/understand why Koller's sickle is important. For example, the introduction mentions the primitive streak as the reason why koller's sickle is important (to separate the hypoblast/area opaca cells from the blastoderm so the primitive streak can form) but it is not explained (i.e. what the primitive streak is/why it is important/what its formation is responsible for in the process of development). This explanation came later, but it makes the intro confusing; if your going to explain the more detailed things like the primitive streak later in the article, it might make more sense not to mention it in the intro, but mention the broader importance of koller's sickle to the process of development instead. This would be more intriguing to the reader (its easy to get lost and confused with all the vocal). Some other terms seemed to be a little out of place/disorganized as well, like Hensen's node. There was an explanation of it in the third paragraph, but it is mentioned in the second paragraph first with no explanation about what it is. I would work on these types of things so it is easier to read the article (that is, explain things when you first mention them, rather than in a later section). It would help the article flow much more nicely and it would be much less confusing for the article. Also, is it the zona pellucida or the area pellucida? Maybe link the article? you could also link "primitive groove", it seems to be very related/important to your topic and linking your page to that one would probably bring more traffic/hits to yours BASEDbio (talk) 22:14, 25 November 2013 (UTC)