Talk:Latent autoimmune diabetes in adults

Improvement of article
This article was in dire need of clarification on the differences and similarites between type 1, type 2, and latent autoimmune diabetes (LADA). I added substantial material including diagnostic testing to help differentiate between the three forms of diabetes and references. Later, when I have time I will also hyperlink diabetes terms to Wiki's definitions.

Hopefully, what is now present in this majorly revamped article, will serve as a solid backbone for others to continue to improve upon (if needed.

I really hope to see this article stay because millions of adults are misdiagnosed as having type 2 diabetes but have LADA and end up insulin dependent for life. It would help many adults to know that not all type 2 diagnosis are correct. Islets of Hope 06:53, 22 May 2006 (UTC)

It is truly important to bring to light the prevalence of adult-onset Type 1 diabetes (LADA or Type 1.5) and the need for correct diagnosis and treatement. In a recent survey conducted by Australia’s Type 1 Diabetes Network, one third of all Australians with type 1 diabetes reported being initially misdiagnosed as having the more common type 2 diabetes. Type 1 diabetes and Type 2 diabetes are different diseases with different genetics, causes, treatments, and cures. Diagnosing an adult with Type 2 diabetes when the person actually has Type 1 diabetes is misdiagnosis and could be construed as malpractice since tests are available to differentiate between the two diseases (antibody testing and c-peptide testing). Misdiagnosis often leads to undertreatment, which hastens the onset of complications and causes needless suffering and potentially death. If the medical community were made more aware that the vast majority of new cases of Type 1 diabetes are adults, then more appropriate care might be given. The appropriate treatment for Type 1 diabetes is exogenous insulin, with intensive treatment begun as early as safely possible after Type 1 diabetes is diagnosed. People who have immune-mediated diabetes, including LADA, should not be treated as if they have Type 2 diabetes. Although Islets of Hope has made a good start, there is some information here that should be updated. First, the United States National Institutes of Health defines LADA as "a condition in which Type 1 diabetes develops in adults." According to the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (as published in Diabetes Care, Volume 30, January 2007), "Although the specific etiologies of [Type 2] diabetes are not known, autoimmune destruction of beta-cells does not occur." Furthermore, the Expert Committee’s definition of Type 1 diabetes by the clearly encompasses all autoimmune diabetes, regardless of age, which includes LADA (“Type 1 diabetes results from a cellular-mediated autoimmune destruction of the beta-cells of the pancreas. In Type 1 diabetes, the rate of beta-cell destruction is quite variable, being rapid in some individuals (mainly infants and children) and slow in others (mainly adults).”) Redyoga (talk) 23:22, 6 October 2009 (UTC)

Stub classification
I have classified this article as a stub as it needs a lot of work such as wikification and sourcing. Capitalistroadster 06:13, 12 July 2007 (UTC)

Steps for improvement

 * 1) Properly cite references (see wp:cite)
 * 2) Add a table comparing Type 1, 2 1.5 and LADA

Userbox
I'm sorry that I'm not in a position to work on this article at the moment. But I can contribute a userbox... Arikk (talk) 21:22, 26 October 2009 (UTC)


 * Thank you. As I've recently had my Type II diabetes re-diagnosed as LADA, I'd like to use this.  Where do I put it, and how?  JDZeff (talk) 23:17, 7 October 2017 (UTC)

ISU Student Class regarding LADA
Thank you guys on your own improving on this piece of diabetes article in Wikipedia. We students began studying Latent Autoimmune Diabetes three years ago, although at that time not enough information existed which could be really trusted. Some diabetes groups—in particular, the American Diabetes Association—often get LADA confused alongside adult type 01 diabetes too frequently.

Moreover, contrary to whatever certain source on diabetes might be saying, some people with Latent Autoimmune do carry family histories of T2DM in their brothers, sisters, uncles, aunts, parents, nieces, nephews, etc. That's because a TCF7L2 gene has association with type 2 diabetes which is shared with the LADA.

Also, not every Latent Autoimmune Diabetic Adult is skinny or slim—certain Latent Autoimmune resources say that some people affected with the Latent Autoimmune Diabetes are plus sized; these plus sized people often receive incorrect diagnoses and treatment because of their weight and because that TC7FL2 (and possibly certain other genes connected with type two may trigger enough resistance to insulin, making the individual acutally look like classic T2. ISU Students from 129.255.1.116 (talk) 16:48, 23 November 2009 (UTC)


 * When I was first diagnosed as Type II, I was 5'10" and 216 pounds. Now, fourteen years later, I've been re-diagnosed with LADA.  I've shrunk a tad, so I'm 5'7" and I weigh about 163, and have been down below 150 at one point.  The loss had nothing to do with diabetes, but it's been hard at times to maintain a proper weight while keeping my blood sugar under control.  I mention this to show that in my case, at least, my weight doesn't seem to have any effect on my diabetes one way or the other, something that other diabetics looking here might find useful.  (It's here, not in the article because it's only an anecdote, and not appropriate for the main article.)   JDZeff (talk) 21:28, 6 July 2016 (UTC)

Disambiguation hatnote
This article currently has a disambiguation hatnote at the top of the text. This hatnote indicates that LADA is the primary target for searchers of Diabetes type 1.5. However, in this edit on 15 July 2009 editor Jfdwolff indicated that some users might be looking for Ketosis-prone diabetes when searching for type 1.5. That generated a need for this hatnote. For more information about this see Talk:Diabetes type 1.5. Please do not remove this hatnote without discussion and consensus. Thanks. --Bejnar (talk) 03:42, 16 October 2012 (UTC)


 * I am simply following WP:BRD and I gave an explanation why I didn't think the hatnote was useful. Please provide evidence that anyone uses "DM type 1.5" to describe ketosis-prone DM2. I support the redirect from diabetes type 1.5 to this page, but I don't think a hatnote is required. JFW &#124; T@lk  06:23, 16 October 2012 (UTC)
 * JFW asked: Please provide evidence that anyone uses "DM type 1.5" to describe ketosis-prone DM2. The issue is not whether any academic uses type 1.5 to described KPD, but whether anyone searches that way. JFW indicated that such inquiry would likely be the case when JFW added the Ketosis-prone option to the Diabetes type 1.5 article page and turned it into a disambiguation page, with this edit and this edit. In that second edit summary JFW said it is definitely a disambig - the term is applied to both. KPD is referred to in the literature as an intermediate form of diabetes. See the articles there cited.  Also, not everyone is comfortable with including KPD with type 2. See the articles there cited.  --Bejnar (talk) 17:02, 17 October 2012 (UTC)

Should be renamed
This article should be renamed to Latent autoimmune diabetes in adults, since that is the full, complete term. --125.25.44.133 (talk) 01:51, 3 June 2013 (UTC)


 * Named Latent autoimmune diabetes of adults instead. JFW &#124; T@lk  19:53, 7 January 2014 (UTC)


 * Seems like in adults is the correct term, may I ask why of was used? All sources use in. ping. --Treetear (talk) 12:00, 2 December 2018 (UTC)


 * Agree based on review of the sources (both in this article and basic literature search). "Adult-onset autoimmune diabetes" is also used, see 10.1038/nrendo.2017.99 JFW &#124; T@lk  06:41, 9 December 2018 (UTC)

Issues on LADA
The fact is, Latent Autoimmune Diabetes of Adults could be between three million and eight million Americans depending on whatever sources are there. There are also TCF7L2 genes associated with the Latent Autoimmune Diabetes. I wanna also mention some people who have LADA do have a family history for Type 2, and that T2DM is very similar to LADA, though unlike Type 2 Diabetes, this medical condition is autoimmune. LADA is very serious, that's a reason more proper sources may be best to verify the actual information. Furthermore, not everyone is skinny or thin: some may be overweight when having the LADA. I have a female cousin with LADA. This LADA article may require whatever sources are there that can verify these connections to LADA.

September 1988 00:18, 6 January 2014 (UTC)


 * If you could provide us with WP:MEDRS-compliant sources (reviews or textbooks) it might be easier to have a constructive discussion here. 10.1210/er.2007-0026 is a source that is relevant to intermediate diabetes states (it discusses three forms). Of course overweight people can have islet autoimmunity, and "double diabetes" is recognised. Fundamentally, there is an overlap territory. JFW &#124; T@lk  23:16, 6 January 2014 (UTC)

I do not understand why anyone would make the false statement that "Type 2 diabetes is very similar to LADA." LADA is Type 1 diabetes, and Type 2 diabetes is in no way similar to LADA. Type 1 diabetes (including LADA) and Type 2 diabetes are altogether different diseases (different genetics, causes, treatments, cures). In The Type 1 Diabetes Sourcebook (ADA/JDRF 2013), the editors say: We want [medical] providers to know that patients with T1D are not the same as patients with T2D; thus, we describe the specific approaches for patents with T1D across the life span. Page 73 and The pathophysiology of the two diseases [T1D and T2D] differ on a basic pathophysiologic level such that T1D is marked by insulinopenia while T2D is characterized by obesity, hyperinsulinemia, insulin resistance, and relative insulinopenia. Page 104. — Preceding unsigned comment added by Redyoga (talk • contribs) 06:01, 3 March 2016 (UTC)

Medical advice
There are many areas within this article that imply medical advice. I think that rewording these particular parts is necessary in accordance with Wiki Policy (c.f., WP:MEDRS). 148.177.1.211 (talk) 19:31, 12 January 2015 (UTC)

Sourcing for the History section
See for a review source. LeadSongDog come howl!  19:56, 12 January 2015 (UTC)

COI editor
The (apparently retired) editor appears to be related to the website [isletsofhope.com], which xhe selfcited as a reference in this article while copypasting text. This wp:copyvio has stood for several years, but still needs to be removed, as it violates several policies. Even if its use were legal, the source cannot be considered to be wp:MEDRS. LeadSongDog come howl!  21:36, 12 January 2015 (UTC)

the copyright notice
For what reason is there a copyright notice on this page Latent autoimmune diabetes of adults? What material is in violation of any copyright? Please tell me. Angela Maureen (talk) 17:52, 31 January 2015 (UTC)
 * I'm not the person who tagged the article, Angela Maureen, but all of the content copied from without verified permission. --Moonriddengirl (talk) 15:01, 3 February 2015 (UTC)

Copyright problem removed
Prior content in this article duplicated one or more previously published sources. The material was copied from: http://www.isletsofhope.com/diabetes/symptoms/latent_autoimmune_diabetes_lada_1.html. Copied or closely paraphrased material has been rewritten or removed and must not be restored, unless it is duly released under a compatible license. (For more information, please see "using copyrighted works from others" if you are not the copyright holder of this material, or "donating copyrighted materials" if you are.) For legal reasons, we cannot accept copyrighted text or images borrowed from other web sites or published material; such additions will be deleted. Contributors may use copyrighted publications as a source of information, and according to fair use may copy sentences and phrases, provided they are included in quotation marks and referenced properly. The material may also be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Therefore such paraphrased portions must provide their source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously, and persistent violators will be blocked from editing. While we appreciate contributions, we must require all contributors to understand and comply with these policies. Thank you. Moonriddengirl (talk) 15:05, 3 February 2015 (UTC)

Latent autoimmune diabetes of adults in general
Not many medical physicians know about LADA in the U.S.,; there's only the basic Type 1 diabetes or Type 2 diabetes. Also, not many magazines about diabetes publish info related to latent autoimmune diabetes. There should be more information about latent autoimmune diabetes than there is now. Angela Maureen (talk) 18:19, 20 February 2015 (UTC)
 * Please use this space to discuss the article. This is not a forum for general discussion of the topic. Thanks Jytdog (talk) 19:52, 20 February 2015 (UTC)

the primary source problem
It says the article relies too much on refs to primary sources. Please tell me about the problem. Angela Maureen (talk) 01:42, 26 February 2015 (UTC)
 * hi, thanks for asking. per the policies, WP:OR and WP:VERIFY, and the guideline WP:RS, everything in WP should be sourced from secondary sources and primary sources should be used rarely and with care.  For health-related content, this is even more important.  There is a guideline for health content, called WP:MEDRS.  It describes what are considered to be reliable secondary sources for health related content. (and if you wonder why WP is more anal about health content, please make sure you read the lead of MEDRS, and maybe also see the lead of my draft essay,  Why MEDRS?.  thanks again for asking. Jytdog (talk) 01:51, 26 February 2015 (UTC)
 * i put a template at the top of this page, that contains automatically created links to reviews at pubmed. those will generally be OK secondary sources per MEDRS. generally. Jytdog (talk) 01:52, 26 February 2015 (UTC)

Role of race in diagnosing LADA
I happened to see this general press article about the role of race in diagnosing LADA. I am posting this because I thought this might be of interest. Medical issues are not my expertise, but I was wondering if anyone has seen anything about the impact of race in LDA diagnosis in secondary or tertiary sources in medical literature (e.g., something WP:MEDRS worthy). Peaceray (talk) 17:35, 9 January 2024 (UTC)


 * Thanks for sharing, Peaceray. Sadly, that's not surprising. There's substantial literature on how Black, Native American, and Hispanic folks are underdiagnosed, misdiagnosed, and ignored when it comes to diagnosing a broad array of conditions in the US. The more a disease is studied, the more literature there will be covering that element of it (example from lung cancer since I was working on that article recently). If there's not substantial literature for LADA, it's only because it's a bit of an up-and-coming disorder. Some folks consider it just slow-and-late-onset type 1 diabetes, so it's sometimes lumped into that for statistics. I'm (slowly) working on updating the type 1 diabetes article now, and will move onto the other diabetes types next. If no one beats me to it, I'll poke around and see if I can find some nice sources on this. Ajpolino (talk) 18:25, 9 January 2024 (UTC)