Talk:Levoamphetamine

Skeletal Formula Change
I'm no expert, so just a suggestion- if l-amp is explicitly described as a stereoisomer as d-amp, then why include the CH3 in this diagram but not the one on the d-amp page? AKAIK it's implicit right?RebelBodhi (talk) 02:42, 22 February 2012 (UTC)

Absolutely no citations
This article is lacking in citations, not to mention it seems to be quite incorrect. From what I understand, levo rotations of amphetamine molecules cause it basically to act peripherally, I can't see how this compound could be euphoric at all, else levomethamphetamine would not be OTC. C6541 (T↔C)  04:26, 5 March 2010 (UTC)

Further Research Needed
An enantiomerically pure version of l-amphetamine is believed to most likely be strictly peripherally active, as opposed to centrally active. Unfortunately, there is very little research on the levorotary enantiomer of amphetamine, as most known research has been studied with racemic amphetamine or enantiomerically pure d-amphetamine. —Preceding unsigned comment added by Mert91 (talk • contribs) 15:11, 8 March 2010 (UTC)

This is a poorly written article. It uses terms that don't exist in the medical literature e.g. "sub-encephalized". It incorrectly describes the activity of the isomers, e.g. the levo- form has clinically zero CNS effects (no, it does not create a more "raw" high) and equal (not greater) CV effects to the dextrorotatory form. Paragraph 4: The calculation of the probability of adverse neurologic effects is meaningless: the vast majority of adverse neurologic effects due to meth are based on CV toxicity: e.g. high BP resulting in intracrnial hemorrhage or hypertensive encephalopathy. This paragraph is useless: dextrometh is equally dangerous to levometh as they have the same CV activity (dextrometh is however the only one that will get you high). — Preceding unsigned comment added by 68.63.80.3 (talk) 05:09, 14 March 2013 (UTC)

Mechanism of action
It is interesting how this chemical has been abandoned, in a sense that seemingly no reliable data is available for the wikipedia. But to clarify the above discussed statements:

http://jamanetwork.com/journals/jamapsychiatry/article-abstract/490807

And on the history, use, etc: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666194/

What complicates matters is that amphetamines act on MAO. If I remember correctly, 'l-am' is the metabolite of a certain MAOI, selegiline. Of course the leaflet doesn't brag about that "unimportant" fact. But it well explains why people write fluent, meaningful, long articles after just a single dose, whereas any psychiatrist will tell you that antidepressants, especially MAOI take weeks to start acting (generally true, but not always). — Preceding unsigned comment added by 178.143.136.17 (talk) 21:33, 2 December 2016 (UTC)