Talk:Lipoic acid

Association with insulin autoimmune syndrome
My edit, in which I added a mention of alpha-lipoic acid causing insulin autoimmune syndrome, was rolled back due to the use of a "doubtful" journal. Would then this reference pass the mark? This is a 2010 review published in Diabetology International, the official journal of the Japan Diabetes Society. --CopperKettle (talk) 22:10, 20 July 2023 (UTC)

Association of ALA with the syndrome is also discussed in this 2016 review in Clinical Chemistry and Laboratory Medicine - is it a good source? --CopperKettle (talk) 22:16, 20 July 2023 (UTC)


 * "Association" in a limited number of cases is weak evidence. I looked, and found no WP:MEDRS sources for a cause-and-effect relationship between LA and IAS. Zefr (talk) 22:28, 20 July 2023 (UTC)
 * Why shouldn't it be mentioned? The syndrome is rare, it may take decades before anybody runs any kind of study to support cause-and-effect. It is mentioned in endocrinology textbooks and in reviews, that's a fine enough reason to mention it in an encyclopedia to me. --CopperKettle (talk) 22:39, 20 July 2023 (UTC)

The association is also mentioned in the Oxford Textbook of Endocrinology and Diabetes 3e (2022). --CopperKettle (talk) 22:25, 20 July 2023 (UTC)

Also mentioned in Williams Textbook of Endocrinology (2019) --CopperKettle (talk) 22:37, 20 July 2023 (UTC)


 * Mention of a possible association and unproven theory is unencyclopedic. For medical content, we use WP:MEDASSESS - those sources would be in the orange section of the levels of evidence. Zefr (talk) 23:05, 20 July 2023 (UTC)
 * If you read into it, you will clearly see that it's not "association", and it does bring on the condition. I used the term "association" just once, by myself, to couch it in a less definite light. There's no need concentrate so hard on the word I've used once. --CopperKettle (talk) 04:11, 21 July 2023 (UTC)
 * It's mentioned in textbooks, which are good secondary sources, thus I see no reason to avoid mentioning it. --CopperKettle (talk) 04:12, 21 July 2023 (UTC)
 * Let me quote from the MEDASSESS page you've provided the link to: "A tertiary source summarizes a range of secondary sources. Undergraduate or graduate level textbooks, edited scientific books, lay scientific books, and encyclopedias are tertiary sources." --CopperKettle (talk) 04:17, 21 July 2023 (UTC)
 * Another quote: "Medical textbooks published by academic publishers are often excellent secondary sources." --CopperKettle (talk) 04:18, 21 July 2023 (UTC)