Talk:Long-chain-fatty-acid—CoA ligase

Wrong title??
As the article's title indicates, this entry should be about an enzyme, acyl-CoA synthase, and not a gene... Can anyone please explain me this? Thank you very much

Tina says: The entry is about the acyl-CoA synthetase enzymes. The mention about the genes that encode the enzymes is only at the end of the page, under "Examples". —Preceding unsigned comment added by 198.82.20.161 (talk) 18:57, 17 May 2011 (UTC)

Help... In figure 3, step 3, the curved arrow should point at the carbonyl carbon, not the phosphorus.70.106.89.23 (talk) 02:18, 13 March 2010 (UTC)

Mechanism image
Should the mechanism image be removed? Thanks, Vokesk (talk) 15:11, 27 April 2012 (UTC)
 * I wonder about the name adenine triphosphate. Adenine is indeed the base, but ATP is a triphosphate of the nucleoside adenosine.
 * I was under the impression that a magnesium ion stabilizes the alpha phosphate's trigonal bipyramidal transition state in step one (not bonding with the other two phosphates). What has the research shown? Are side chains of the enzyme complimentary to these phosphates or is it really the Mg ion?
 * Why does step 3 depict coenzyme A forming a bond with the phosphate? The next image depicts CoAS bonded to the acyl carbon?
 * The final product is labeled "Produt"
 * Must R always be long chain C-C bonds?
 * Are these all completely reversible reactions?
 * Are the formation and collapse of transition states separate steps? Is this mechanism really four unique steps or two steps with two transition states (or something else)?

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