Talk:Lovastatin

Curious
Curious about users and how you've reacted to this and other statins.

I've had nausea, vomiting, exercise intolerance, memory problems, depression.

I've stopped the med against MD orders and tried a second one (at MD's insistance) and only took one dose.

I'm only 50, and very concerned about long term on this and similar meds. I plan to live a very long life....so are these safe after 10 years? 20 years? longer?

(I'm also not too sure about this cholesterol = heart disease theorey.....but that's another discussion!)

Cindy

Statins may cause these side-effects. If you've tried all of them, you may be better off with a fibrate (they are also effective). If you do not believe the cholesterol/heart disease theory you're disagreeing with a rather hefty body of scientific research. I'm not sure if I would take the risk :-). I think the benefits of cholesterol lowering vastly outweigh the "risks" you are concerned about. Many people have been taking simvastatin since its discovery, and are probably still alive because of it, not despite it. JFW | T@lk  09:56, 28 Jan 2005 (UTC)

I'm concerned about taking these because Adicor's website says that it's not proven that their drug prevents cardiovascular disease or heart attacks. http://www.advicor.com/About_Advicor/What_Is_Advicor.asp Is there a statin that does have proof? Bob


 * This page is not for chatting about personal experiences.   WhatamIdoing (talk) 28 Jan 2005 (UTC)

Treating Neurofibromatosis I
There's some research to suggest that statin drugs may be effective in treating the cognitive problems associated with neurofibromatosis I. (At this point, just animal studies -- human trials are pending or in progress.) It may be worth watching for more information on this, and if the effect is confirmed by the scientific community, we should mention it here. Not yet, though. 66.67.222.16 15:20, 24 November 2006 (UTC)

Lovastatin and niacin
Re the statement in the article, "Lovastatin at doses higher than 20 mg per day should not be used in conjunction with gemfibrozil, niacin, cyclosporin, or other fibrates. This is because of the significantly increased risk of rhabdomyolysis": Advicor is a formulation of 40mg lovastatin with 1g time-released niacin (Niaspan) and the manufacturer does not mention this side effect on their Web site (http://www.advicor.com/About_Advicor/Advicor_Safety_Side_Effects.asp). Can we have an informed comment or edit of the entry? —Preceding unsigned comment added by Larrykoen (talk • contribs) 15:06, 8 September 2007 (UTC)

cholesterol and heart disease
"It is now generally accepted that a major risk factor for the development of coronary heart disease is an elevated concentration of plasma cholesterol, especially low density lipoprotein (LDL) cholesterol. The objective is to decrease excess levels of cholesterol to an amount consistent with maintenance of normal body function."

- from the article

there's good evidence that chronic inflammation plays a key role in atherosclerosis, and that just lowering cholesterol does not stop this process. it turns out that statins inhibit inflammation, and this may be how they reduce the risk of congestive heart failure.

Duane Graveline wrote an informative book about statins, their effects on the body's cholesterol-based building blocks, and the widespread misunderstanding about cholesterol's role in atherosclerosis.

- Rgrant (talk) 23:42, 27 November 2007 (UTC)

Longstanding copyvios?
It appears that the contribs by an inactive SPA in June 2007 may have contained copyvios. Can someone check (I don't have access here) The subject matter and writing style in the abstract seem very close. The exact wording appeared in a blog entry later, but that could have been copypasted from WP. I've deleted the section for now, but if someone else can check and confirm it I'd certainly feel better. I think a proper rollback will likely be needed to get it out of the edit history. LeadSongDog come howl!  20:54, 17 May 2010 (UTC)

chemical data
the half life listed here reads in the range of 1 to 2 hours, however online sources 1 2 state a half life of 4.3hrs (specifically 4.3+/-2.0/3.7+/-2.5 h from European Journal of Clinical Pharmacology article accepted at NIH). I think it mayt be of interest to also note the flash point (185.3ºC 3) and solubility in water (25ºC 4) for anyone concerned about health and safety in eating the natural foods (for example oyster mushrooms) that contain this chemical. (Preparation under 185.3ºC/~365F in the oven, or in water at 25ºC/77ºF that is kept in the meal can be expected to contain lovastatin.) --—  r obbie  page talk 14:47, 10 July 2011 (UTC)

This might be a dead horse already, but i still would like to point out that neither " solubility in water 25 centigrades", nor "preparation in water at 25 centigrades in order to have the finished meal contain the Lovastatin" seem to make sense - not in a chemist sense of the word, but rather (and even) in common sense or at the grammatical level of thse two statements.

why: solubility is a continuum and not a yes-or-no matter; solubility also makes only sense if desribed by some quantative ratio; also solubility per se doesnt tell how much of the soluable material would move from eg. a piece of uncut mushroom while it is cooked; depends on cooking time as well; then 25 centigrades is the temperature of cold tap water, so theres no use of "cooking" at that temperature; finally it would depend on the type of meal being cooked, whether the cooking water is discarded, eg. a soup would not loose any content due to soluability. 80.98.79.37 (talk) 22:47, 21 July 2017 (UTC).