Talk:M1G

Adduct?
Is it an "adduct" or it is more correct to put it as an "adduct-forming chemical", for adduct consists of both DNA and the chemical? -- C opper K ettle  05:15, 2 June 2009 (UTC)


 * Thanks for pointing out the problem. I modified the text to fix this as well as several other inaccuracies.  Cheers.  Boghog2 (talk) 07:03, 2 June 2009 (UTC)
 * I'v upped the image to the Commons. -- C opper K ettle  07:31, 2 June 2009 (UTC)

The second way

 * ; from a free fulltext: "The pyrimidopurinone adduct, M1dG, forms from reactions of 2‘-deoxyguanosine (dG) with either the DNA peroxidation product, base propenal (8−10), or the lipid peroxidation product, malondialdehyde (10−12) (Scheme 1)."-- C opper K ettle  12:47, 2 June 2009 (UTC)


 * Opps. I guess that I misinterpreted the citations. So M1G is the DNA adduct while pyrimido[1,2-a]purin-10(3H)-one is the product of repair of the DNA adduct. I will revise in the next day or two to correct the error.  Thanks for catching my mistake  Cheers.  Boghog2 (talk) 22:13, 2 June 2009 (UTC)


 * This is somewhat confusing. M1G is pyrimido[1,2-a]purin-10(3H)-one while M1dG is the product of repair of the DNA adduct.  I will expand the article to include the second pathway.  Cheers. Boghog2 (talk) 18:37, 3 June 2009 (UTC)


 * OK, I think article is now accurate, but perhaps not very accessible to the general reader. I will try to make it clearer by adding a graphic of the reaction scheme when I find some time.  Boghog2 (talk) 20:54, 4 June 2009 (UTC)