Talk:MHC restriction

Untitled
Hi, i will be working on this article and here are some sources I will be using. Please feel free to offer you suggestions! Thank you. :) Immcarle8 (talk) 07:53, 30 January 2016 (UTC)

Hi, this is the revised lead section for this article. For the body of the article, I would like to first introduce the concept of MHC restriction in more detail, introduce the significance of MHC restriction, talk about the arguments regarding the two models for MHC restriction, and at last describe the process of MHC restriction development.

MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell can interact with both the self-MHC molecule and the foreign peptide that is bound to it, and will recognize the peptide antigen only when it is bound to a host body's own MHC molecule. As T cells are stimulated by peptide antigens only in the presence of self-MHC molecules, MHC restriction adds another dimension to the specificity of TCR so that an antigen is recognized only as peptide-MHC complexes.

MHC restriction in T cells occurs after its development in the thymus, specifically after positive selection. Only the thymocytes (developing T cells in the thymus) that are capable of binding, with an appropriate affinity, with the MHC molecules can receive a survival signal and go on to the next level of selection. MHC restriction is significant for T cells to function properly when it leaves the thymus because it allows T cell receptors to bind to MHC and detect cells that are infected by intracellular pathogens, viral proteins and bearing genetic defects. Two models explaining how restriction arose are the germline model and the selection model.

The germline model suggests that MHC restriction is a result of evolutionary pressure favoring T cell receptors that are capable of binding to MHC. The selection suggests that not all T cell receptors show MHC restriction, however only the T cell receptors with MHC restriction are expressed after thyme selection. In fact, both hypothesis are reflected in the determination of TCR restriction, such that both germline-encoded interactions between TCR and MHC and co-receptor interactions with CD4 or CD8 to signal T cell maturation during selection. Immcarle8 (talk) 05:02, 9 February 2016 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle8.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 03:02, 17 January 2022 (UTC)

Body section
Hi, I am an Immunology student and i just added body sections to the article page. Please let me know if you have any views or suggestions! I will really appreciate your input. :) Immcarle8 (talk) 06:30, 15 February 2016 (UTC)