Talk:Macrolide

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Untitled
just a minor quibble here, but don't you think we ought to mention what a macrolide IS? 165.123.175.203kajerm

Why is the part about the combination of macrolide and statins in the article head? It has nothing to do with describing or summarizing macrolides.

Can someone include side effects of the various macrolides. I've been prescribed two different tupes. Both had bad reactions. Is there an intolerant gene to these?

This page seems remarkably similar to (ie identical in most parts) to http://www.cempra.com/programs.html. Some acknowledgment by either site seems appropriate

I find the statement about macrolides being used to treat enterococcal infections to be false. macrolides are not used to treat these infections because they are usually resistant to macrolides. —Preceding unsigned comment added by Sean.evans (talk • contribs) 15:16, 24 January 2008 (UTC)

typo?
Is the "Macrolides include:" an error when under the heading Ketolides??

Ketolides Ketolides are a new class of antibiotics that are structurally related to the macrolides. They are used to fight respiratory tract infections caused by macrolide-resistant bacteria. Ketolides are especially effective as they have a double-binding site.

Macrolides include: —Preceding unsigned comment added by 198.103.184.76 (talk) 18:30, 3 February 2011 (UTC)

The classification is mixed up: spiramycin - tylosin do not belong to ketolides. The semisynthetic ketolides is a subgroup within the macrolides of 14-membered ring system (such as erythromycin) Tgunda (talk) 10:57, 20 March 2012 (UTC)

Lyme disease
A comment was placed on the Discussion page of Lyme disease: "I don't think this information is contradictory. The 4 studies you referenced, one of which studied late stage encephalopathy (not 'chronic lyme') all used either doxycycline or ceftriaxone. However, these are not macrolide antibiotics. The distinction is quite important, because the modes of action are very different among different antibiotic groups. There has never been a peer-reviewed study of macrolides in lyme, especially the utility in treating late stage or chronic versions of the disease. So there is no established conclusion as to whether or not long term macrolides offer benefit. As much as can be said in this arena is stated by the entry, that physicians have noted the utility of the treatment." Can anyone confirm this?

Also, it is said here that treating Lyme Disease requires antibiotics that will cross the blood-brain barrier. Will macrolides do this? Simesa (talk) 15:18, 5 July 2009 (UTC)

Erythromycin and Clarithromycin Images
Why are the structural images for Erythromycin and Clarithromycin identical? Why the ethyl group on Erythromycin?

Curious Wylde (talk) 21:33, 31 January 2014 (UTC)
 * The images for erythromycin and clarithromycin are very similar, but not identical. They differ by a hydroxy (OH) group in erythromycin being a methoxy (OCH3) group in clarithromycin.  It's a distinction that is hard to see in the complicated chemical structures, but it is near the center of the images.  -- Ed (Edgar181) 23:45, 31 January 2014 (UTC)

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Strict/loose sense
The article seems to straddle across two different senses of the word "macrolide", between "any big ring lactone" and "a specific family of antibiotics with a ring of size 14-18". Some sections like Examples take the former stance, while other sections (History, Mech. of action) take the latter. That's confusing, especially since the other uses tend to involve very different-looking molecules with quite different ring sizes (& somehow we don't put in pics to show that they look different!). Artoria2e5 🌉 01:01, 29 September 2023 (UTC)