Talk:Medical cannabis/Archive 6

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Peer reviewers: Trevor Jenkins.

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Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Peer reviewers: Brianmaucsf.

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Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 April 2019 and 9 May 2019. Further details are available on the course page. Student editor(s): Artalek510.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 00:48, 18 January 2022 (UTC)

Opening sentence - definition
This revert was justified because the edit proposes medical cannabis as an "idea". Sources in the lede show medical cannabis exists as a prescription drug in some cases and the Society and culture section shows its use as a legalized generic drug or prescribed medicine in many countries. The proposed first sentence by is opinion that could be developed with facts and WP:RS sources in the Society and culture section. Zefr (talk) 21:59, 12 October 2021 (UTC)
 * The entry for China makes it pretty clear that cannabis was used medicinally in ancient times. I'm not sure why there needs to be some type of modern legalistic or state-centric bona-fides for this?  Valgrus Thunderaxe (talk) 20:32, 23 January 2022 (UTC)

Risk of schizophrenia in adolescents
The wording of this in the article is somewhat misleading. Cannabis use has never caused schizophrenia but can catalyze existing cases of prodromal schizophrenia. This is elucidated in the whitepaper that is cited as the source for this statement: To be clear, the use of cannabis in adolescence does not cause schizophrenia but increases the risk of its onset, suggesting interplay between marijuana use and genetic predisposition for schizophrenia.

Also, it would be helpful to link to the full text of the paper rather than just the abstract. A full text is publicly available at the following link: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.1187 12.227.70.210 (talk) 15:17, 1 February 2023 (UTC)
 * The Borgelt source is properly cited and linked. It is a little old now. A more recent source like 31708042 provides better knowledge of the phenomenon of cannabis-induced psychosis in adolescents. Bon courage (talk) 15:30, 1 February 2023 (UTC)

Outdated research - edit of 02-19-2022
Not sure I follow the logic of  "move to Research section - not a medical use; trim excessive narrative and primary + outdated recreational research".

The edit left the older review from 2019 while removing the newer review from 2022. Also removed the study that best demonstrates the bias in these studies. Badgettrg (talk) 04:33, 20 February 2023 (UTC)


 * The main statement under Medical uses is "it is not clear whether it is a useful treatment for any condition, or whether harms outweigh any benefit," which remains as the existing clinical and regulatory positions. The 2019 review was a much larger analysis than the 2022 review, and adequately stated the prevailing concern about cannabis research to date: "most reporting an inability to draw conclusions due to inconsistent findings and a lack of rigorous evidence." While including only 18 RCTs compared to the 72 reviews of the 2019 report, the 2022 review comes to a similar conclusion about "variation in interventions, lack of study details, including unclear availability in the United States, and inadequate evidence for some products", i.e., it reports no new information, and is a limited review of ongoing low-quality research (and it is offtopic for the medical uses section - it is only a review of primary research, and not about any certainty of medical uses).
 * The MUSEC trial, published in 2012, was limited primary research not useable in an encyclopedia; see WP:MEDASSESS. This and this are more recent reviews of using cannabis for MS spasticity, but neither review provides enough certainty as examples of medical uses. Zefr (talk) 19:18, 20 February 2023 (UTC)

Pharmacodynamic
Hello,

Maybe it would be interesting to add this recent study in the article pharmacodynamic section:

Recently, it has been shown that THC is also a partial autotaxin inhibitor, with an apparent IC50 of 407 ± 67 nM for the ATX-gamma isoform. THC was also co-crystallized with autotaxin, deciphering the binding interface of the complex. These results might explain some of the effects of THC on inflammation and neurological diseases, since autotaxin is responsible of LPA generation, a key lipid mediator involved in numerous diseases and physiological processes. However, clinical trials need to be performed in order to assess the importance of ATX inhibition by THC and other cannabinoids during medicinal cannabis consumption.

Cheers Math283 (talk) 16:09, 22 February 2023 (UTC)


 * That is conjecture based on primary lab research too preliminary to mention. The encyclopedia relies on WP:MEDSCI reviews to describe mechanisms. Any implication of anti-disease effect would need a systematic review or clinical practice guideline, WP:MEDASSESS. Zefr (talk) 17:58, 22 February 2023 (UTC)
 * OK it is maybe a bit too early to mention this particular target, human research is still needed to assess ATX inhibition by cannabinoids.
 * Just a suggestion here. Maybe it would be worth add a line or two about PPAR activation by cannabinoids. It's not mentioned in the article but you can found a good review summarizing all the clinical and fundamental research evidence (DOI:10.1111/bph.13497). It is now clear that the pharmacodynamic of cannabinoids cannot be relying only on CB1 and CB2 receptors, but also on some other targets.
 * Cheers Math283 (talk) 18:13, 22 February 2023 (UTC)

Infobox
@Zefr I noticed you removed the medical infobox. I included it because it is a prescribed drug in many countries, as opposed to an alternative medicine (note that in Australia, alternative medicines are classified as complementary medicines, whereas medicinal cannabis is approved by the TGA, note that this varies in other countries). If you don't want to include the medical infobox, which infobox should be included? Thiscouldbeauser (talk) 03:30, 17 June 2023 (UTC)


 * There was no useful information in the infobox and the image was a generic picture not representative of anything medicinal. Zefr (talk) 15:32, 17 June 2023 (UTC)
 * Is there anything that would need to be added? Thiscouldbeauser (talk) 09:25, 18 June 2023 (UTC)