Talk:Metabolic pathway

Untitled
the first external link (dmoz.org) isn't functioning. does someone know where that page has been moved to?

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Some Questions
Is it really necessary to have such a large space between the image and the next section "Cellular respiration". According to whoever added those spaces it was done for a 17" screen. I have a wide-screen computer, does this huge space still exist for anyone else?

Also, what exactly the point of the "Cellular respiration" section, if it is even that. As of now it's just a bolded title. Does the title and text following it refer to 'Metabolic Pathways and Cellular Respiration'? It's tite should be more specific. I'm also not sure that all of the text following the title actually belongs there, considering the fact that Photosynthesis and Chemosynthesis are certainly not processes of Cellular respiration. Does that make them part of a whole new section? Could someone who knows about this topic help figure this out as I am certainly no expert. --France3470 06:16, 7 May 2007 (UTC)


 * I have removed the huge space.It is not necessary. Shrimp wong (talk) 04:47, 14 February 2008 (UTC)

Reversibility
If "all reactions are chemically reversible," why do charts of metabolic pathways often display arrows that aren't double-ended? I think "all" should be changed to "most." Unfree (talk) 01:12, 30 November 2008 (UTC)

All chemical reactions are reversible but to varying degrees. The threshold where one decides that a reaction is considered irreversible is arbitrary. It might be better to simply say that "all reactions are chemically reversible to varying degrees". --Rhodydog (talk) 19:38, 6 January 2009 (UTC)

Flux Generating Step
I noticed the phrase "flux generating step" near the start of the article, what exactly is a flux generating step? I think such terms should be defined, unfortunately I've no idea what it is so I can't help. --Rhodydog (talk) 19:39, 6 January 2009 (UTC)

definitions
Should there be definitions to distiguish the words pathway, superpathway and map? The word superpathway which features heavily in metacyc and all those who cite it is quite handwaving, hence the question. --Squidonius (talk) 02:21, 29 May 2011 (UTC)

Biochemical pathway
See my comment in the talk of metabolic network. The two articles are basically overlapping and both slightly wrong. This article does not restrict itself to metabolism, and does not talk only of pathways, a notion that is now attached to directionality. Nowadays, one would talk about metabolic networks and signaling pathways. Sometimes of biochemical pathways/networks. But metabolic pathways is a notion that is fading rapidly because imprecise and slightly wrong (because of directionality). Nicolas Le Novere (talk) 13:16, 16 November 2011 (UTC)

Flux Generating Step
Top of page: "To initiate another metabolic pathway, called a flux generating step" - There is not such thing as a flux generating step, see Kacser and Burns, 1973 on Control of Flux. Rhodydog (talk) 18:46, 14 May 2014 (UTC)

Plan for editing the page
I am currently planning to edit this page, so I compiled a list of references I plan to use. Any feedback is greatly appreciated.

Bibliography of References

 * 1) Fundamentals of Biochemistry.
 * 2) Major Metabolic Pathways and Hormone Production in Unstimulated Monolayer Cultures of the Rate Anterior Rituitary.
 * 3) Metabolic Pathways of Glycerol Dissimilation.
 * 4) The Quarterly Review of Biology.
 * 5) Molecular Biology: Principles and Practice.
 * 6) Life: The Science of Biology.
 * 7) Organic Chemistry.

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Outline for Editing the Article
I propose the following strategy for organizing this page and incorporating new material: I will add new sections and categorize them based on the classes and subclasses of metabolic pathways. It is important to expand on the topic by promulgating on the different types of pathways that occur in eukaryotes and prokaryotes. Furthermore, I will specify and briefly describe several important metabolic pathways and the roles they each play in the cell.

In addition, the provided information about metabolic pathways in this article lacks proper structure in order to be efficient in conveying that information; hence, I will rearrange some of the already mentioned material to allow for comfortable reading and a better conceptual understanding.

Finally, I intend to add proper citations for the information provided to allow for a smoother verification of the stated facts.

Any feedback on my proposition is greatly appreciated.

Sazhnyev (talk) 12:36, 5 May 2016 (UTC)

New map of Metabolic Pathways
I've replaced the map of metabolic pathways to a new one. Feel free to comment here or at Wikipedia_talk:WikiProject_Molecular_and_Cell_Biology. Chakazul (talk) 17:43, 10 June 2016 (UTC)
 * For reference, the old interactive image was, and the updated one is . T.Shafee(Evo&#65120;Evo)talk 10:23, 11 June 2016 (UTC)
 * I am impressed by the level of detail of the new infographic. Additionally, I've placed the old map at the end of the section titled External Links, for it provides further visual elaboration of the metabolic pathways. Sazhnyev (talk) 05:42, 12 June 2016 (UTC)

More Citations Needed
There are a lot of claims in the Overview section that are most likely true, but are not properly cited. For instance, the article claims that "Glycolysis was the first metabolic pathway discovered," but it does not provide a source. Avevanduz (talk) 22:30, 19 March 2017 (UTC)

General Comments
The last paragraph of the first section of this article(Metabolic pathway) is missing a word and does not make sense as it stands: "The end product of a pathway may be used immediately, initiate another metabolic pathway or be stored for later use." In addition to this minor grammatical issue, as noted by other users, this article is missing proper citation in some areas. Over all this article could be expanded to discuss more aspects of the full chart for metabolic pathways. Wasso392 (talk) 13:06, 21 March 2017 (UTC)

Number of metabolic pathways?
How many metabolic pathways are know? a) Completely? b) Partial?

How many metabolic pathways are there, that are unknown - estimation?

What is the number of metabolic pathways in the brains vs. number of metabolic pathways in the rest of the body? — Preceding unsigned comment added by 92.192.14.162 (talk) 08:29, 15 July 2017 (UTC)

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1 st Para. Do these sentences make sense ?
1. "In most cases a metabolic pathway, the product of one enzyme acts as the substrate for the next."

Should it not be "In most cases of a metabolic pathway"

2. "However, set products are considered waste and removed from the cell." What are set products ? Should it not be "some products" — Preceding unsigned comment added by Ruskin (talk • contribs) 08:57, 10 March 2018 (UTC)

There is no formal definition of a metabolic pathway on the page
At present, it says: "In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.", but it's more than that. A pathway is a linked series of reactions that can sustain a steady state. See "A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks", Schuster and Fell and Dandekar, Nature Biotech, 2000, 18, 326-332. These authors define pathways in terms of elementary modes which is a nice formal way of defining what exactly a metabolic pathway is. Rhodydog (talk) 22:15, 16 April 2018 (UTC)