Talk:Methoxyflurane

Background
"the field of halogen chemistry [...] was poorly understood until around 1940." This sentence is complete rubbish.

Prior to the Manhattan project fluorine chemistry was a very specialized area of chemistry because both fluorine and hydrogen fluoride were (and still are) very difficult to handle (corrosive, toxic etc.). During the Manhattan project alloys were developed so that these compounds could be used on an industrial scale to prepare uranium hexafluoride for the isotope separation plant. The ready availability of fluorine led to renewed interest in organo-fluorine chemistry, which was underdeveloped relative to organo-chorine chemistry at that time. Petergans (talk) 19:30, 22 November 2010 (UTC)
 * Thank you for your comment, Petergans. Please feel free to improve this section as you see fit, hopefully providing inline citations. Respectfully, DiverDave (talk) 00:58, 24 November 2010 (UTC)
 * The modified text is fine. One other point: UF6 is not the only volatile compound of uranium. During the Manhattan Project hundreds of compounds were examined and UF6 came out as the best. This info is in declassified USAEC reports to which I don't have access now. The molecular weights of the two isotopic hexafluorides are 289 and 292. It is this difference which is the basis for gaseeous diffusion separation as, according to Graham's law the rate of diffusion is inversely proportional to the square root of of the molecular weight. 235UF6 diffuses 1.0052 times faster than 238UF6. This figure is more significant than the difference in molecular weights.
 * I would not say that Miller's work was part of the M-P. It was a spin-off. Petergans (talk) 09:43, 24 November 2010 (UTC)
 * Your comments are appreciated, and I have made a few more changes in accordance with your suggestions. Accuracy is important. For some reason, I thought the molecular weights of 235UF6 and 238UF6 were closer to 349 g/mol and 352 g/mol. This point is a little off-topic for this article, but it is appropriately discussed in the article on gaseous diffusion. Cheers, DiverDave (talk) 16:52, 24 November 2010 (UTC)

Be prepared for increased interest in this article due to news
I was on the Twitter today and noticed that the New York City EMS website had posted an update. Apparently, methoxyflurane has continued to be used, just as the Wikipedia article says, as an anesthetic agent in Australia/ New Zealand. However, there is a new financial deal which will expand use of it in Europe, see Australia's pain relieving 'green whistle' is closing in on a $70 million deal in Europe (29 June 2015). Selectively quoting, emphasis mine:

"Medical Developments International, the company behind Australia’s “green whistle” pain relief inhaler, is near to closing a $US54.5 million licensing deal in Europe. The company says it has signed a term sheet and will now move to contract with an as-yet unnamed “significant pharmaceutical” group with expertise in pain management products to distribute Penthrox, the Melbourne-made emergency pain killer... it will be responsible for investing into the development of Penthrox and registering Penthrox throughout Europe... Medical Developments International is using a new lower cost manufacturing process developed with the CSIRO to increase production of Penthrox’s underlying drug methoxyflurane by ten-fold."

Shares of the company, Medical Developments Int'l, are up 12% in one day. That means that there will be lots of interest in this Wikipedia article. I am not suggesting that we add the Business Insider news story as a link to the article. I mention this only as a heads up to editors.

Personally, I am kind of curious why the nephrotoxicity issues are not receiving more attention, but that is neither here nor there for now.

One other aside: This is a GREAT Wikipedia article! Analytical chemists, no, chemistry professionals in general, are AWESOMELY thorough! --FeralOink (talk) 23:30, 29 June 2015 (UTC)

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External links modified (January 2018)
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I have just modified 3 external links on Methoxyflurane. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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 * Added archive https://web.archive.org/web/20110727181737/http://www.nps.org.au/health_professionals/publications/nps_radar/2010/may_2010/methoxyflurane to http://www.nps.org.au/health_professionals/publications/nps_radar/2010/may_2010/methoxyflurane
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