Talk:Methylenetetrahydrofolate reductase

2008 Comment
Any chance of turning up some research with the MTHFR C667t mutation and link to recurrent miscarriages? This looks like it's not been edited in a while. —Preceding unsigned comment added by 75.23.32.119 (talk) 03:41, 13 October 2008 (UTC)


 * The scheme could be made more vertical, IMHO, for it takes up much horisontal space, with the two pictures side by side. Best regards, -- C opper K ettle  19:14, 25 August 2009 (UTC)


 * There are many updated articles related to MTHFR C677TT and Childhood Leukemia, some of which now directly dispute the article currently sited. I am not ready to edit, but I encourage continued research and updating by someone who is specifically interested in this area. Blood Journal 2010, has two. http://bloodjournal.hematologylibrary.org/cgi/reprint/103/1/252?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=mthfr+c677t&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT, http://bloodjournal.hematologylibrary.org/cgi/reprint/104/10/3046?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=mthfr+c677t&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT It is my hope someone with a direct interest in this subject that is off a research background take the time to update the information on this page. —Preceding unsigned comment added by Kfrank73 (talk • contribs) 17:51, 1 November 2010 (UTC)


 * Because MTHFR gene variations can be a very significant contributor to repeated miscarriage, I suggest this article gets a higher importance factor.

MetaMetrix makes a supplement of Methyltetrahydrofolate (MTHF), FolaPro, which can be used (as a lifetime supplement) to compensate for the MTHFR gene variants that can't convert folic acid to MTHF. MTHFR = methelynetetrahydrofolate reductase; MTHF = Methyltetrahydrofolate. Without the effective reductase action, your body can't make enough of the folate form. You also won't have an efficient methylization cycle to clean up all kinds of junk in your body. Work with your medical doctor to test for MTHFR defects and appropriate supplementation. Cassiebabe (talk) 02:38, 23 March 2012 (UTC)

The intro paragraph does not list all of the currently known health issues caused by this polymorphism and makes it appear that it all inclusive:

INCORRECT: "Genetic variation in this gene may influence susceptibility to occlusive vascular disease, neural tube defects, Alzheimer's disease and other forms of dementia, colon cancer, and acute leukemia ..."

CORRECT: "Genetic variation in this gene may influence susceptibility to occlusive vascular disease, neural tube defects, Alzheimer's disease and other forms of dementia, colon cancer, acute leukemia, Fibromyalgia, Chronic Fatigue, Irritable Bowel Syndrome, Autism Spectrum Disorders, Peripheral Neuropathy, Cardiovascular risks associated with high Homocystiene like Cardiovascular disease, Atherosclerosis, Stroke, Deep Vein Thrombosis (clots), Folate deficiency related pregnancy and development problems like Still Births / miscarriage, Pre-Eclampsia, Neural tube defects (cleft lip, cleft palate, etc), Neurotransmitter issues like Depression / Anxiety, Insomnia, Dementia, Schizophrenia, Parkinson’s, Addictions, Significant decrease in ability to eliminate toxins, especially heavy metals like High oxidative stress in all body systems, Contributes to: immune disorders, allergies, autoimmune issues, fatigue, headaches, insomnia, mood issues, thyroid and menstrual disorders, kidney damage, neurological symptoms, cancer risk and other issues. Further research is being done and updates to this article are expected. These occur because mutations in this gene are associated with methylene tetrahydrofolate reductase deficiency.[3][4]

http://www.drsobo.com/conditions-treated/mthfr-genetic-mutation/ http://www.doctorbecky.net/mthfr.shtml

2015 Comment
Due to the commonality, severity and numerous issues associated with this polymorphism I strongly recommend this article be upgraded to Class A in order to educate patients and doctors and prevent or deminish chronic diseases or life threatening conditions.

73.164.150.93 (talk) 07:13, 26 March 2015 (UTC) Traci
 * You probably should've clicked "new section" above. "A Class" has nothing to do with the importance of an article; you're thinking of []. The relevance of any association between MTHFR and that rather large number of diseases is not very well-supported in the references provided. Statistical correlation is not proof of causation (many such relationships elucidated in published literature turn out to be spurious or of less relevance than initially appeared to be the case). The purpose of Wikipedia is not to offer warning (or guidance) to medical professionals or the general public; it is merely to be as neutral and factually complete a source of information as possible. See WP:NOT. With all due respect, it's worth pointing out that your comment seems like hypochondriac alarmism, and it is very unlikely that you know more about what should especially concern doctors/other healthcare providers than they themselves. Blacksun1942 (talk) 11:54, 26 March 2015 (UTC)

MTHFR testing only appropriate in rare cases?
"There are more than 3,000 published papers examining this one gene, often of varying quality, and in connection with a slew of frightening diseases. Critics of the test worry that someone without medical training may not understand how to evaluate the nuanced and often contradictory evidence."

-- https://www.washingtonpost.com/news/wonk/wp/2015/09/11/the-powerful-argument-for-not-learning-too-much-about-your-genes/?tid=a_inl

-- Jo3sampl (talk) 22:04, 6 June 2016 (UTC)

2017: Time for the Next Level
I think it's time to "kick it up a notch", and I want to see who is interested. I happen to not agree with this topic being rated as low importance, etc. I also would like to see what collaborative interest there is in improving the quality of this article. Some of the information is just not correct --- for example, statements made about relationship to diet and folic acid -- and it just echos a lot of false information around the internet. It's time to stop considering folic acid, Vitamin B9, and folate to be the same thing. Further, I agree with comments made earlier that --- I presume inadvertently --- descriptions of medical ramifications make it seem like an inclusive list when there real list of issues is quite huge. Particular polymorphisms of the MTHFR gene leading to issue with the enzyme activity can be particularly detrimental. Finally, for now, I have also read some saying testing is not important, and such statements are utter nonsense. From what I have read, they come from so-called medical experts who appear to have not studied methylenetetrahydrofolate reductase and methylation cycles at all. Uberveritas (talk) 18:14, 20 April 2017 (UTC)


 * Clearly this article can be improved, but before doing that, we must identify reliable sources to support any changes/additions. Per WP:MEDRS, any biomedical statements should be supported by reliable secondary sources (review articles). The definitions of Folate, folic acid, and vitamin B9 is more appropriate on the Folate page. They clearly are the same thing. Boghog (talk) 18:32, 20 April 2017 (UTC)

External links modified (January 2018)
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New article in The Atlantic
[https://www.theatlantic.com/science/archive/2019/05/vaccines-dna-23andme/589915/ Why Anti-vax Doctors Are Ordering 23andMe Tests: Naturopaths have long been obsessed with a gene called MTHFR. Now vaccine skeptics are testing for it too.]

Key quote: "The anti-vaccine movement is decidedly outside of mainstream medicine, but it has always borrowed the language and trappings of mainstream science. By tapping into the wider interest in genetics, vaccine skeptics are attempting to tap into scientific legitimacy. The early hype about the power of genes and the early spate of now outdated research made genetics research all the more exploitable." --Guy Macon (talk) 07:25, 25 May 2019 (UTC)

677TT allele is associated with reduced risk of colon cancer not increased risk of colon cancer
The 677TT allele is associated with reduced risk of colon cancer not increased risk of colon cancer as you can see from this article published on pubmed:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805460/

Carol Sorsoleil — Preceding unsigned comment added by 24.183.142.216 (talk) 10:49, 3 January 2020 (UTC)