Talk:Mevalonate pathway

Rename article to mevalonate pathway
The mevalonate pathway is more commonly used and accepted than HMG-CoA reductase pathway. So, I think, the mevalonate kinase a better one as the article title.
 * In any case having abbreviations in the title is not proper either. One way or another, this article should be retitled. I don't know the topic well enough to know what's best, so maybe others can make suggestions. Edgar181 12:49, 22 February 2006 (UTC)
 * You are right. I will do it. The pathway also ends with production of prenyl-diphosphate --Kupirijo 03:06, 5 December 2006 (UTC)

Page moved. Cheers. -GTBacchus(talk) 04:36, 10 December 2006 (UTC)

structure of 3-hydroxy-3-methylglutaryl CoA
I believe you have to many carbons in 3-hydroxy-3-methylglutaryl CoA, the carbon attached to the carbonyl at position 5 needs to be a OH/O- group.
 * I agree, and have left User:Jag123 a message requesting the fix. --David Iberri (talk) 14:56, 3 August 2006 (UTC)
 * Is anybody going to fix it? Do we have a repository of chemical structures in svg format? It would be nice if we had a database of ChemDraw structures. Does anybody know?--Kupirijo 15:59, 11 October 2006 (UTC)

Refs
added some content followed by a number of references, but there is no referencing to them. I've moved them here for... well... reference.

Holstein, S. A., and Hohl, R. J. (2004) Isoprenoids: Remarkable Diversity of Form and Function. Lipids 39, 293−309

Miziorko H (2011) Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys 505:131-143.

Goldstein, J. L., and Brown, S. B. (1990) Regulation of the mevalonate pathway. Nature 343, 425−430

Buhaescu I, Izzedine H (2007) Mevalonate pathway: areview of clinical and therapeutical implications. ClinBiochem 40:575–584.

Dellas, N., Thomas, S. T., Manning, G., and Noel, J. P. (2013) Discovery of a metabolic alternative to the classical mevalonate pathway. eLife 2, e00672

Vinokur JM, Korman TP, Cao Z, Bowie JU (2014) Evidence of a novel mevalonate pathway in archaea. Biochemistry 53:4161–4168.

Azami Y, Hattori A, Nishimura H, Kawaide H, YoshimuraT, Hemmi H (2014) (R)-mevalonate-3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. J Biol Chem 289:15957–15967.

"Lipitor becomes world's top-selling drug". Crain's New York Business. 2011-12-28.

JFW &#124; T@lk  09:27, 29 July 2015 (UTC)

Alternate diagram
Other related articles use this image - seems clearer - should we offer both ? - Rod57 (talk) 10:29, 7 January 2016 (UTC)

Did that OH group disappear?
On the step with mevalonate 5 PP decarboxylase, there is a loss of OH group. Is it just me? Please explain XXGuyWithAnAxeXx (talk) 14:58, 11 February 2019 (UTC)
 * You mean probably this reaction? Yes, hydroxyl is removed after phosphorylation. HlTo CZ (talk) 15:44, 29 September 2020 (UTC)

Buhaescu & Izzedine
The first reference (Buhaescu I, Izzedine H (2007) Mevalonate pathway: a review of clinical and therapeutical implications. ClinBiochem 40:575–584.) doesn't say anything about distribution of the pathway among eukaryotes, Archaea and bacteria and thus should be replaced. HlTo CZ (talk) 15:47, 29 September 2020 (UTC)