Talk:Moderna COVID-19 vaccine/Archive 1

Technical details
Does anyone have the technical details for mRNA-1273? There seems to be so little information available here and even in regulatory documents and on drug sites, but here's what our description of the Pfizer vaccine now looks like:


 * The modRNA sequence of tozinameran is 4,284 nucleotides long, with a molecular weight of approximately 1388 kDa. It consists of a five-prime cap; a five prime untranslated region derived from the sequence of human alpha globin; a signal peptide coding region (bases 55–102); an optimized sequence which encodes a mutated version of the spike protein of SARS-CoV-2, containing two proline substitutions (K986P and V987P, designated "2P") that cause it to adopt a shape that stimulates neutralizing antibodies (bases 103-3879); the three prime untranslated region (bases 3880–4174); and a poly(A) tail comprising 30 adenosine residues, a 10-nucleotide linker sequence, and 70 other adenosine residues (bases 4175-4284). The sequence contains no uridine residues; they are replaced by 1-methyl-3′-pseudouridine.*

Seems like this would be of utmost importance considering the novelty of mRNA drugs and the wide variations across platforms.  —  C M B J   23:01, 31 December 2020 (UTC)


 * Here's a somewhat more detailed description of the Moderna mRNA-based vaccine:
 * "The mRNA-1273 vaccine candidate, manufactured by Moderna, encodes the S-2P antigen, consisting of the SARS-CoV-2 glycoprotein with a transmembrane anchor and an intact S1–S2 cleavage site. S-2P is stabilized in its prefusion conformation by two consecutive proline substitutions at amino acid positions 986 and 987, at the top of the central helix in the S2 subunit. The lipid nanoparticle capsule composed of four lipids was formulated in a fixed ratio of mRNA and lipid." Reference: Jackson LA, Anderson EJ, Rouphael NG, et al. (2020) An mRNA Vaccine against SARS-CoV-2 - Preliminary Report. New England Journal of Medicine, 383:1920-1931. DOI: 10.1056/NEJMoa2022483.--Jpmcgrath729 (talk) 20:40, 18 January 2021 (UTC)


 * In the Wiki article, "SM-102" is undefined. Perhaps the editors can use the information from Phase 3 protocol specifications on pg. 28, defining SM-102 abbreviation as "heptadecan-9-yl 8-((2-hydroxyethyl) (6-oxo-6-(undecyloxy) hexyl)amino) octanoate".  — Preceding unsigned comment added by 86.58.127.238 (talk) 11:55, 7 January 2021 (UTC)


 * @CMBJ Same exact protein as BNT162b2 (1273 means full length spike including the WT signal peptide, the only mentioned modification is the PP mutation) but who knows we may have surprises. 2A01:E0A:852:9590:CD83:B063:D892:4A25 (talk) 00:30, 9 January 2021 (UTC)

I suggest adding the following to the Design section, based on the references I've indicated:
 * The vaccine encodes a version of the spike protein called 2P -- that includes two stabilizing mutations in which the regular amino acids are replaced with prolines -- developed by researchers at the University of Texas at Austin and the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center.     —   MarcAirhart   17:50, 1 March 2021 (UTC)

Which country?
Wikipedia doesn’t state which country has developed Moderna covid vaccine. It is an important information. — Preceding unsigned comment added by 49.192.4.27 (talk) 22:53, 4 January 2021 (UTC)

The vaccine was codeveloped by researchers at the National Institute of Allergy and Infectious Diseases (NIAID, Bethesda, MD, USA) and at Moderna, Inc. (Cambridge, MA, USA).--Jpmcgrath729 (talk) 20:44, 18 January 2021 (UTC)

Rename to Moderna COVID-19 vaccine
Per Pfizer-BioNTech COVID-19 vaccine, shouldn't this article be renamed to Moderna COVID-19 vaccine? I don't think this needs an RM (given the discussion at Talk:Pfizer-BioNTech COVID-19 vaccine, and pinging who closed the RM), I think identical arguments apply? Britishfinance (talk) 19:28, 16 January 2021 (UTC)


 * Thanks for the ping. I'm going to move it too, for the same WP:COMMONNAME reasons; I don't think having this at mRNA-1273 can sustain scrutiny under our AT policies. No such user (talk) 10:58, 17 January 2021 (UTC)
 * thanks for that! Britishfinance (talk) 11:46, 17 January 2021 (UTC)

COVID-19 Vaccine Moderna safety update
This document was released on Friday.

COVID-19 vaccine safety update for COVID-19 Vaccine Moderna: February 2021.

Not a Controversy
I don't think this is a controversy: "Pregnant and breastfeeding women were excluded from the initial trials used to obtain Emergency Use Authorization." There were probably no people from many other categories. If the company even tried to recruit pregnant women there'd be a media storm. No pregnant women would enroll anyway. This should be moved to the section that describes the trials. — Preceding unsigned comment added by 2601:646:8380:5020:C0F8:BBD7:13E6:648C (talk) 20:49, 4 February 2021 (UTC)
 * There's a tendency to manufacture "controversy", when none exists here. I think it's probably done in good faith in an effort to promote balance in an article, but it's misguided and comes off as inauthentic.  139.138.6.121 (talk) 14:43, 11 March 2021 (UTC)
 * Agree. Moved to Clinical trials chapter. Zach (Talk) 18:07, 11 March 2021 (UTC)

Controversy section
"In February 2021, Moderna said that it was expecting $18.4 billion of its Covid-19 vaccine sales.[92] " What, specifically, is the implied controversy here? 139.138.6.121 (talk) 14:37, 11 March 2021 (UTC)
 * Well spotted. Fixed it. Zach (Talk) 16:40, 11 March 2021 (UTC)
 * Making 18 BILLION DOLLARS is ***INCOMPATIBLE*** with Socialism. 139.138.6.121 (talk) 19:36, 11 March 2021 (UTC)

Date format
Given that this particular article subject was developed by an American company, shouldn't the date formatting on the article follow American standard? (e.g., "On December 18, 2020, mRNA-1273 was issued an Emergency Use Authorization...") Antoshi ☏ ★  13:40, 1 April 2021 (UTC)

More factual info about side effects?
I write as a pro-vaccine person who enthusiastically received my first dose of the Moderna vaccine six days ago.

The article barely mentions side effects (two minor references). Wikipedia as a neutral and factual forum is a good place to provide factual and documented/sourced info about any side effects.

For example, this NEJM article that just appeared documents a significant effect for about 1% of patients: https://www.nejm.org/doi/10.1056/NEJMc2102131.

72.174.46.173 (talk) 05:00, 5 March 2021 (UTC)
 * As per WP:MEDRS we should use reviews rather than studies, which are primary sources Zoozaz1 talk  14:21, 12 March 2021 (UTC)
 * Added this image which is relatively common. Doc James  (talk · contribs · email) 15:30, 1 April 2021 (UTC)

More doses from vials and longer usage times
Moderna Provides Storage Update & Announces the U.S. FDA Authorizes Up To 15-Doses Per Vial of its COVID-19 Vaccine

Fact Sheet for Healthcare Providers Administering Vaccine

FDA Makes Two Revisions to Moderna COVID-19 Vaccine Emergency Use Authorization to Help Increase the Number of Vaccine Doses Available

"'Today, the U.S. Food and Drug Administration announced two revisions regarding the number of doses per vial available for the Moderna COVID-19 Vaccine. The first revision clarifies the number of doses per vial for the vials that are currently available, in that the maximum number of extractable doses is 11, with a range of 10-11 doses. The second revision authorizes the availability of an additional multi-dose vial in which each vial contains a maximum of 15 doses, with a range of 13-15 doses that can potentially be extracted.'"

2600:1000:B037:628E:54F0:F946:E988:7034 (talk) 13:17, 2 April 2021 (UTC)

Worldwide distribution?
I was looking for information how the Moderna vaccinations are distributed worldwide (per country). Would be worth to add? --Christianh (talk) 08:40, 7 April 2021 (UTC)

EU Authorisation
EU is coloured blue on the Authorisation map, but is listed under Full Authorisation in the list below the map. Which one is correct? – 78.59.24.14 (talk) 06:51, 16 April 2021 (UTC)

Funding
I've added a funding section to the article, similar to the one on the Pfizer–BioNTech COVID-19 vaccine article. I did my best to get a diversity of references and to imitate the style and tone from the other article, but I'm a fairly new editor so I'd appreciate if someone could take a look. --Tufts2017 (talk) 16:03, 25 April 2021 (UTC)

Full-length spike protein?
https://en.wikipedia.org/wiki/Pfizer%E2%80%93BioNTech_COVID-19_vaccine

"It is composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the full-length spike protein"

Has also the Moderna vaccine a full-length spike protein? If yes, it should be mentioned in Moderna Wikipedia page.

I suppose the Pfizer article is now a bit unaccurate, maybe it should be corrected to:

full‐length sequence of spike protein, so it is not about size of the protein, but lenght of the codon sequence?

--ee1518 (talk) 20:03, 16 May 2021 (UTC)

Requested move 3 July 2021

 * The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion. 

The result of the move request was: Not moved; consensus is that the article titles policy should take precedence over the manual of style on medicine-related articles.


 * Pfizer–BioNTech COVID-19 vaccine → Tozinameran @ Talk:Pfizer–BioNTech COVID-19 vaccine
 * Moderna COVID-19 vaccine → Elasomeran @ Talk:Moderna COVID-19 vaccine

These two requested moves pose the same question — whether the title of COVID-19 vaccine articles should be the international nonproprietary name (INN) (per the article titles section (MEDTITLE) of the manual of style on medicine-related articles) or the name of the company (or companies) which developed the vaccine concatenated with "COVID-19 vaccine" (which has been argued to be in accordance with the commonly recognisable names section (COMMONNAME) of the article titles policy). Both articles' title is currently the latter. The arguments made in each discussion were also very similar. Therefore, I am closing these discussions as one discussion.

There was not much question on what the manual of style or the article titles policy recommend — in this case, the INN or the company-name concatenation, respectively. Rather, much of the discussion was on which of these takes precedence. While the article titles policy is a policy and the manual of style is a guideline, the manual of style on medicine-related articles is much more specific (and there is no policy giving explicit advice on medical titles). Some opinions were that the manual of style takes precedence due to its specificity. Opposing opinions were varied; some argued that the INNs were not widely used enough in reliable medical sources; others made the point that the company-name concatenations were the common names in (non-medical) reliable sources by a large margin.

While medical guidelines are often stronger than other subject-specific guidelines because it is crucial that Wikipedia provides reliable information in this area (like those for biographies of living people), policies still override guidelines. In this case, the consensus appears to be that the article titles policy is stronger than the manual of style on medicine-related articles, so the company-name concatenations should be used instead of the INNs, and the pages should be not moved.

— (closed by non-admin page mover)  Tol  &#124; talk &#124; contribs 22:32, 12 July 2021 (UTC)

Moderna COVID-19 vaccine → Elasomeran – Move to the drug's international nonproprietary name, naturally with a redirect in place and other common names mentioned in the lead section. Our WP:MEDTITLE guideline governs the naming of Wikipedia articles about drugs, and I find no convincing reason why this particular drug, however popular in 2021, should be an exception.

For clarity, MEDTITLE stypulates:  —  kashmīrī  TALK  14:47, 3 July 2021 (UTC)


 * Oppose "Elasomeran" is rarely used by high-quality medical sources, apart from Therapeutic Goods Administration source. Even CDC and EMA referred it as "Moderna COVID-19 vaccine". The only other names is mRNA-1273, which the name referred by the company itself. 180.243.211.196 (talk) 23:49, 3 July 2021 (UTC)
 * Support: WP:MEDTITLE is unambiguous on this. ― Tartan357  Talk 21:08, 4 July 2021 (UTC)
 * Oppose per 180.243.211.196 above, in addition to "Elasomeran" not even being CLOSE to any sort of widely-known WP:COMMONNAME. Paintspot Infez (talk) 21:13, 4 July 2021 (UTC)
 * , topic-specific guidelines such as WP:MEDTITLE take precedence over WP:COMMONNAME, which is a catch-all guideline. If you can't explain how your position aligns with WP:MEDTITLE, you won't get very far here. ― Tartan357  Talk 21:19, 4 July 2021 (UTC)
 * Also, it would make sense to ping the participants of the ongoing similar discussion on Talk:Pfizer–BioNTech COVID-19 vaccine so they may share their opinions, whether they support or oppose – . Paintspot Infez (talk) 21:13, 4 July 2021 (UTC)


 * Oppose Thanks for the ping! My views are reflected in the two opposition comments. OSSYULYYZ (talk) 21:22, 4 July 2021 (UTC)
 * Support with the same justification as Talk:Pfizer–BioNTech COVID-19 vaccine. This is a medicine-related article, so its title must follow the conventions of medicine-related articles (WP:MEDTITLE), which take precedence over the generic convention of commonly recognized (popular) name (WP:COMMONNAME). Doing the opposite would require a discussion of WP:MEDTITLE rules first, with implications for thousands of other articles. Thanks for the ping! --Fernando Trebien (talk) 21:38, 4 July 2021 (UTC)
 * Oppose thanks for the ping - we should use the most common name recognizable in English language sources, and for the three vaccines available in the US today (Moderna, Pfizer, and Janssen) the most common name is by far the "X COVID-19 vaccine" name. The names of that format are scientific/recognized medical names - they're even used on the CDC/FDA EUA fact sheets still. No change at this time to the commonality of the trade names/INNs (i.e. they're still extremely uncommon). They aren't "unscientific or slang" names, and we must remember that if a rule/guideline prevents us from serving the readers as an encyclopedia, we should ignore it or change the rule/guideline to be the best to serve the readers. -bɜ:ʳkənhɪmez (User/say hi!) 02:06, 5 July 2021 (UTC)
 * Oppose per and "Elasomeran" is not a WP:COMMONAME Run n Fly (talk) 07:11, 5 July 2021 (UTC)
 * , WP:MEDTITLE is a thing. We can't just pretend it doesn't exist. If it needs to be changed, there is a proper procedure for that. ― Tartan357  Talk 07:16, 5 July 2021 (UTC)
 * , I believe WP:COMMONNAME takes precedence over WP:MEDTITLE for COVID-19 vaccines as of today and they are also not a generic drug. Run n Fly (talk) 07:35, 5 July 2021 (UTC)
 * , MEDTITLE does specifically address vaccine names: Most biologics, including vaccines, do not have INN or other generic names, so the brand name is used instead. I see no reason why the guideline should not apply to this vaccine. As for which guideline takes precedence, it must be the topic-specific one. The other way around makes absolutely no sense. ― Tartan357  Talk 07:45, 5 July 2021 (UTC)
 * , It says Most biologics, including vaccines, do not have INN or other generic names. Currently, only two approved vaccines [Pfizer-BioNTech and Moderna] have been allocated INN names out 20+ vaccines worldwide. Thus, for WP:CONSISTENT, WP:COMMONNAME takes precedence. Run n Fly (talk) 07:51, 5 July 2021 (UTC)
 * for help Run n Fly (talk) 10:37, 5 July 2021 (UTC)
 * Oppose Agree with Run n Fly -- &#123;{u&#124; Gtoffoletto  &#125;}  talk 14:00, 5 July 2021 (UTC)
 * Oppose per wp:commonname—blindlynx (talk) 14:32, 5 July 2021 (UTC)
 * Oppose. The current title is by far the common name. Even WHO uses it . -- Calidum  01:23, 6 July 2021 (UTC)
 * Oppose as per WP:COMMONNAME Abrilando232 (talk) 02:25, 6 July 2021 (UTC)
 * Oppose In cases like this, where one term is blatantly more colloquial than the other, WP:COMMONNAME should take precedence over WP:MEDTITLE. — F ORMAL D UDE  ( talk ) 03:27, 6 July 2021 (UTC)
 * Oppose per rationale of Berchanhimez and FormalDude, and WP:COMMONNAME. A. Randomdude0000 (talk) 03:37, 6 July 2021 (UTC)
 * MEDTITLE says: scientific or recognised medical name that is most commonly used in recent, high-quality, English-language medical sources. In MEDRS, the name is mRNA-1273 not Elasomeran. But in any case, oppose both as per COMMONNAME. ProcrastinatingReader (talk) 21:21, 6 July 2021 (UTC)
 * Oppose per very clear WP:COMMONNAME. -- Necrothesp (talk) 14:35, 7 July 2021 (UTC)
 * Oppose per clear WP:COMMONNAME. Re:WP:MEDTITLE I submit this situation is WP:UNPRECEDENTED. Rules can and should here be set aside. Abovfold (talk) 09:58, 11 July 2021 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Table footnotes
regarding your recent reverts, table footnotes using predefined groups next to the table are acceptable according to WP:REFGROUP and H:PREGROUP and you can see this in good articles like OPEC and Windows XP, remaining unchanged in this usage for a long period of time. Therefore, it is incorrect to classify my edits as pushing an agenda. I admit that in my first edit it was not good practice to include footnotes in a table cell, though it is not uncommon, see Philadelphia English, for example. But why do you consider the second edit to be bad practice? --Fernando Trebien (talk) 18:03, 30 July 2021 (UTC)


 * Because the piece of text in question is a note, meaning, it's relevance to the text is secondary. If it was more important, the note should be replaced with prose text right under the table, explaining it. But since it's a note, it belongs in a note section. The article already has a note section. Placing the notes in the middle of the page is just incorrect. What other pages do is irrelevant here. The table you gave as an example, isn't 100% correct. It is missing column and row scopes for example. Gonnym (talk) 18:45, 30 July 2021 (UTC)


 * But since it's a note, it belongs in a note section. Like in Windows XP? --Fernando Trebien (talk) 19:25, 30 July 2021 (UTC)
 * Placing the notes in the middle of the page is just incorrect. So why do articles that meet good article criteria using this type of footnote remain unchallenged for so many years? Scientific articles often do this in tables. This saves the reader from having to jump to another location many times when parsing a table. --Fernando Trebien (talk) 19:25, 30 July 2021 (UTC)
 * If it was more important, the note should be replaced with prose text right under the table, explaining it. It can get complicated as more research is published filling different data points. Although it is not an issue at the moment for this particular vaccine. --Fernando Trebien (talk) 19:25, 30 July 2021 (UTC)
 * The table you gave as an example, isn't 100% correct. It is missing column and row scopes for example. It's true, but it's not part of the tutorial and it is also very rare, so I doubt there are any implications for the issue of table footnotes. --Fernando Trebien (talk) 19:25, 30 July 2021 (UTC)

For many months, table footnotes have also been used in the following articles, which are being actively edited and revised by many every day: --Fernando Trebien (talk) 11:31, 8 August 2021 (UTC)
 * COVID-19 vaccine in List of authorized and approved vaccines, Efficacy and Effectiveness
 * Variants of SARS-CoV-2


 * Seriously, what's your point? Some articles do it one way, others do it another. Some do it better, others worse. See MOS:NOTES where the section specifically talks about a note section. Notice this sections is under the level 2 heading of Manual of Style/Layout, see how it says When appendix sections are used, they should appear at the bottom of an article. Gonnym (talk) 12:04, 8 August 2021 (UTC)
 * Seriously, what's your point? This saves the reader from having to jump to another location many times when parsing a table. So, precision and brevity. Perhaps some of the notes that apply to the entire table can be moved to prose (such as the notes in the table caption), but not all, as in the case of notes on studies that provide several (but not all) data points. It might be easier to see this in (same notes for multiple cells, but not all) and  (some notes for rows, some for columns). --Fernando Trebien (talk) 13:57, 8 August 2021 (UTC)

Hi all, from 3rd Opinion here. I lean towards not placing the notes next to the table. I am not against adding notes next to the table as a rule, sometimes notes are important to comprehend data in a table, but this is not the case. Also, I would like to note that the argument "it happens in other articles" is pretty weak. Reason is that many errors happen in other articles. Had an argument like that survived, it would help spreading errors. Each article is build by the editors following firstly their common sense and secondly policies and guidelines of WP. Trying to mimic MoS or other patterns of other articles is not the way forward.Cinadon36</b> 21:03, 8 August 2021 (UTC)

Suggestive evidence of vaccine efficacy (serum studies)
reverted my addition  of a systematic meta-analysis of studies of serological neutralization to support the phrase: "a systematic meta-analysis of published results found that Moderna's mRNA-1273 vaccine is effective against the Delta variant with a slightly reduced neutralizing effect." The editor asserted that the source was not a MEDRS.

I'd like to point out the assertion that this data cannot be used as evidence of effectiveness is inherently flawed. The study is systematically analyzing studies which take serum from vaccinated patients, and test it against the delta variant. That's a clinical effectiveness study. As a guy who got his PhD doing these studies, and regularly reviews these studies, it is absolutely considered "supporting evidence of effectiveness" to have serum taken from the people who got the vaccine, and test it against live virus, evaluating "neutralization." This is exactly how the influenza vaccine is approved every year. A neutralization titer of a certain level is considered a "correlate of protection" in these established viruses (like flu) but is considered "suggestive" evidence of protection in novel viruses. I would be amenable to changing the text to "suggests that the vaccine may be effective" if that is the concern. My initial wording may have been too WP:BOLD. Because it does suggest that the vaccine is effective. Only observational cohort studies or RCTs can truly prove it definitively, and only then for a single point in time. You also don't need to trust me on all of this, you can trust these MEDRS sources:

The CDC:

The WHO:

These reviews which describe this method to measure/investigate effectiveness of viral vaccines (both routine and novel):

Should we should, therefore, include this systematic review in citing the following? a systematic meta-analysis of published results suggests that Moderna's mRNA-1273 vaccine may be effective against the Delta variant with a slightly reduced neutralizing effect. -- Shibboleth ink (♔ ♕) 03:37, 9 August 2021 (UTC)
 * I know that the effect of neutralizing antibodies is a strong correlate of immune protection, but I don't think it is correct to call that evidence of efficacy (or, by extension, effectiveness). But you can argue that, due to the strong correlation between neutralizing antibodies and efficacy seen in COVID-19 vaccines, high efficacy against Delta is likely. Based on this study, the WHO, in its weekly situation reports (see epidemiological update 49 ) has recently adopted an approximate relation between efficacy and the measured fold change in neutralizing activity. The study you pointed out says, about Delta, that Fifty percent neutralization titre was decreased up to 8.4 fold as compared with the reference strain which the WHO considers similar to a change of −30% to −20% in efficacy, which in previous weekly reports was described as a "moderate reduction" by the WHO. But, the true efficacy may be outside this range. In addition, on Table 4, the study reports other serological assays with a smaller fold change. In WHO's epidemiological update 49, they also reported a smaller fold change for Moderna against Delta based on many studies, which helps support the claim that it is likely effective. --Fernando Trebien (talk) 14:39, 9 August 2021 (UTC)

Genetic Material addition Semi-protected edit request on 25 August 2021

 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. ScottishFinnishRadish (talk) 15:49, 25 August 2021 (UTC)

Genetic Code
The genetic code of the vaccine has been reverse engineered by Stanford scientists and has been disclosed to the public with a silense consent by Moderna. The Stanford scientists saved drops of the COVID-19 vaccine destined for the garbage can, reverse engineered them, and have posted the mRNA sequence in Github for the scientific community to explore: https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273. the vaccine is also posted in Pubmed: (https://pubmed.ncbi.nlm.nih.gov/32756549/) What is apparent when compared to the Pfizer genetic material which was also reverse engineered is that the two vaccines have a similar first part while the Moderna vaccine has extra 585 bases which encode the haemoglobin. Wikicontri-x (talk) 15:43, 25 August 2021 (UTC)
 * , Hi, I think you may have used an alignment tool incorrectly. When I compared the two sequences using ClustalW, it's clear that the two vaccine sequences are nearly completely identical. It is the Pfizer vaccine which is slightly longer, by 152 base pairs.
 * This corresponds to a slightly longer 3' untranslated region for Pfizer. See here also for the comparison of the people who published the sequences. Nothing unusual about this finding, though. And we already discuss the reason for it in the this section of the Pfizer vaccine article. Basically, BioNTech added some bases from another gene which is known to increased protein expression and mRNA stability in transit.
 * I think what may have happened for you is that you may have copied and pasted the sequence into a comparison program which already contained the sequence for hemoglobin, a common "starting" sequence for such website-based sequence comparison programs.— Shibboleth ink  (♔ ♕) 23:56, 25 August 2021 (UTC)
 * I think what may have happened for you is that you may have copied and pasted the sequence into a comparison program which already contained the sequence for hemoglobin, a common "starting" sequence for such website-based sequence comparison programs.— Shibboleth ink  (♔ ♕) 23:56, 25 August 2021 (UTC)
 * I think what may have happened for you is that you may have copied and pasted the sequence into a comparison program which already contained the sequence for hemoglobin, a common "starting" sequence for such website-based sequence comparison programs.— Shibboleth ink  (♔ ♕) 23:56, 25 August 2021 (UTC)

Add as fully approved?
It's fully approved in the US now for those 18 and older. Could someone please update (and the associated articles on the status of Covid vaccines)? https://www.usatoday.com/story/news/health/2022/01/31/covid-vaccine-mandate-cases-deaths/9278653002/ Difbobatl (talk) 17:49, 31 January 2022 (UTC)

Storage
"In February 2021, the restrictions on the Pfizer vaccine were relaxed when the U.S. Food and Drug Administration (FDA) updated the emergency use authorization (EUA) to permit undiluted frozen vials of the vaccine to be transported and stored at between −25 and −15 °C (−13 and 5 °F) for up to two weeks before use.[42][50][51]"

Very interesting. But it's all about the Pfizer vaccine and seems to have no relevance to Moderna. — Preceding unsigned comment added by 80.94.115.69 (talk) 04:17, 7 April 2021 (UTC)

Japan
'''ADD: Adverse effects: ''' In early December 2021, the Japan Health Ministry recommended men Men aged 12-29 to choose Pfizer-Covid-19 Vaccine over Moderna due to a higher incident of myocarditis and pericarditis in men who received the Moderna vaccine. Health Ministry Ofifcials did not explain what could have caused this. However gealth officials debated, according to NHK, whether they should recommend the Pfizer vaccine for all young men. Conclusion reached that due to heart inflammation cases also linked to Pfizer, although much lower rate than Moderna COVID‑19 vaccine, they decided to let men aged 12-29 to choose either at their discretion. Achezet (talk) 13:55, 30 December 2021 (UTC)

Semi-protected edit request on 13 February 2022
It is misinformation that the HEK 293 cell line was created from an elective abortion. Human embryonic kidney 293 cells, derived from a spontaneous miscarriage or a pregnancy that was terminated in order to save the life of the mother. This is undeniable because at the time of the fetus' death abortion was illegal in the Netherlands. 2603:8000:4A06:A6D8:B8C7:7DF9:B23:1443 (talk) 05:37, 13 February 2022 (UTC)
 * irrelevant. Alexbrn (talk) 05:53, 13 February 2022 (UTC)

Semi-protected edit request on 16 August 2022
Change:

A bivalent version of the vaccine containing elasomeran/elasomeran 0-omicron (Spikevax Bivalent Zero/Omicron)[46] is approved for use in Australia.[13]

to:

A bivalent version of the vaccine containing elasomeran/elasomeran 0-omicron (Spikevax Bivalent Zero/Omicron)[46] is approved for use in the UK[New citation], and pending approval in Australia.[13]

New citation: https://www.gov.uk/government/news/first-bivalent-covid-19-booster-vaccine-approved-by-uk-medicines-regulator 110.174.65.51 (talk) 16:44, 16 August 2022 (UTC)
 * Pictogram voting wait.svg Already done Aaron Liu (talk) 21:54, 19 August 2022 (UTC)