Talk:Molecular genetics

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 August 2020 and 11 December 2020. Further details are available on the course page. Student editor(s): Imahoney26. Peer reviewers: Cmbio401.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 01:10, 18 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Creason.e.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 04:23, 17 January 2022 (UTC)

Untitled
please read what's been added and correct anything that needs to be corrected. Kccccc 03:45, 13 May 2007 (UTC)

how to find out a gene for certain genetic disorder.


 * Geez, try OMIM. JFW | T@lk  20:02, 27 Dec 2004 (UTC)

Artificial Intelligence

Isn't there an AI project called MOLGEN that has something to do with mollecular genetics? If so, perhhaps there should be a reference or something? Rorykillhorn 13:04, 13 May 2007 (UTC)

instructor comment
"Molecular genetics studies the genes, which compose DNA, and the hereditary traits the genes carry. These hereditary traits are those traits that pass from generation to generation." This addition only repeats information contained in the first sentence of the original article.

Second paragraph in lead, which you added, does add new information.

Gene therapy: This is the topic of an extensive article in Wikipedia. Wny no reference to it? Your information is different from that provided by that article and a useful supplement, but these topics must be coordinated.

"Many severe medical conditions result in mutations in the person's genes." result in means the opposite of result from. Which do you intend?

"These mutations cause the protien encoded by that gene to malfunction and cells that rely on this protein cannot function properly and cause problems for the whole tissue or organ." Sentence contains spelling and grammatical errors. A spell check in Wikipedia editing window underlines spelling errors in red.

"explore the process of the gene" meaning? "From there," from where? "There are several approaches to gene therapy:..." You follow this with a long quote that lays out the approaches. The quote should not do your work of exposition. A quote is used to present specific wording of the source when that is necessary or to support a point that you have made with textual evidence. Otherwise, you should paraphrase, demonstrating your own comprehension and re-expression of the material. "There have been several set backs in the last 15 years that have restricted further measures on gene therapy. As there are unsuccessful attempts, there continues to be a growing number of successful gene therapy transfers which has furthered the research." Reading this aloud should surface grammatical error, echo, and excessive use of the stylistically weak variants of "there is" "there are." The last sentence in this section is out of logical sequence.

"is the approach which" words without meaning

"Classical gene therapies usually require efficient transfer of cloned genes into the disease cells to the introduced genes are expressed at high levels." read this

"The size of the DNA fragments that can be transferred are very limited," read this

three general techniques"--why "general"?

More "there are"s

"Projects in Molecular Genetics" Only one project is included.

I assume that you understand all the material presented here. It's hard for me to follow some of the descriptions of techniques, but they appear to make sense.

Not dealing with the Gene Therapy article is a serious problem. Otherwise, this can be cleaned up with the edits suggested.

C-

Rudolph2007 16:19, 16 May 2007 (UTC)

Molecular Drive
Is anyone familiar with this concept? It was first promoted by Dover in [Nature] which is not from what I understand a nonsensical journal. This article in Nature "Cryptic simplicity in DNA is a major source of genetic variation" Nature 322, 652 - 656 (14 Aug 1986), Diethard Tautz, Martin Trick, Gabriel A. Dover, refers to it and has four endnotes citing supporting works. See this one, too. It seems to have to so with the way gene conversion, transposition, and unequal crossing over, that all have the same effect, an increase in a gene's frequency within an individual, and explain concerted evolution, independent of drift or natural selection ... I think it also is connected to evo-devo. I do not know enough about it to add anything to this article, but from what I have read it seems relevant and perhaps someone else can address it? Slrubenstein  |  Talk 16:25, 25 May 2007 (UTC)

According to this article, molecular genetics "studies the structure and function of genes at a molecular level." But this article seems to have more information on the manipulation of genes than on what the study of the the structure and function of genes at the molecular level has revealed to us about embryology, genetics, or evolution. Can't someone add to this article some of the science, and not just th techniques? Slrubenstein  |  Talk 16:28, 25 May 2007 (UTC)

Assessment comment
Substituted at 00:19, 30 April 2016 (UTC)

External links modified (February 2018)
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Evaluation of Molecular Genetics - Fall 2019
Molecular Genetics https://en.wikipedia.org/wiki/Molecular_genetics

I have selected this article because it is an area of interest in my graduate program and I am currently taking a class on molecular genetics.

Lead evaluation The lead section’s introductory sentence links two concepts, “molecular biology and genetics,” in hopes of providing an explanation of the field of molecular genetics. The citation source used for that introduction actually has an excellent description of molecular genetics as an ‘investigative approach” that was excluded from the lead section and should be included. The lead section has a contents box to present the article’s individual sections, but doesn’t actually describe the sections. The closing sentence of the lead section delineates the relevance and importance of the study of molecular genetics. Overall, the lead section is very concise, but missing relevant information to clearly explain the study of molecular genetics.

Content evaluation The content may be relevant to the topic, but it comes across as disjointed and incomplete. Particularly in the Technique section, the overarching goal and the rationale for using the individual techniques is not stated. There are techniques missing like RNAi, which is mentioned, but not explained, in a later section on genetic screens that should be included in that section. Gene therapy is quickly summarized in a section but does not discuss the ethics or limitations. Then, there is a section on the Human Genome Project that lists the goals of the project, but not how the information gleaned from that project is being used today.

Tone and balance evaluation While the article trends towards neutrality and doesn’t try to persuade the reader one way or the other, the lack of discussion about the ethics and limitations of gene therapy makes the article biased in favor of gene therapy as an “appealing” and successful technique. One should note that the article does state that gene therapy is “still in development” and “mostly used in research settings”, which also might lead a reader to question the reasons that gene therapy is not widely available to the public.

Sources and references evaluation Some of the facts in the article are backed up by reliable secondary sources, but some article content is missing citations. Within the present citations, two of the sources do not have a working link (6, & 14), one source appears to be the protocol from a Qiagen kit (5), and one appears to be summary notes that one might be given in class and has no source (7). One of the citations references a source that provides an excellent definition of the study of molecular genetics, which should have been used in the lead sentence and was not included (1). That same source then focuses on a philosophical discussion of the concept of molecular genetics for the duration of the article and the discussion is not included in the Wikipedia article. The sources may have been current at the time of the original article production, and although a great deal of research has been conducted since, there is currently a dearth of secondary and tertiary sources that would be valuable in improving this article. However, a summary article on NCBI, “Molecular genetics made simple,” would be a great reference (Kassem et al., 2012). Organization evaluation The article is concise and does seem to utilize verbiage that is comprehensible to the average individual. There are no spelling issues, but multiple grammatical errors are present (e.g. patients should be patient’s). Although multiple sections exist that should be included, the order of the sections might be improved.

Images and media evaluation No images are included in the article to provide pictorial examples of content that might aid comprehension.

Talk page evaluation After the initial comments by the instructor to the student originally writing the article in 2007, there is very little talk about the article and very few edits. Molecular genetics has been rated a C-class article because it requires cleanup in the form of more citations, as well as additional content material. The topic falls under the WikiProject Molecular and Cell Biology/Genetics and has been given top priority for elaboration and improvement. The article discusses some topics covered in our class, like forward and reverse genetic screens as well as techniques used in the laboratory (e.g. molecular cloning, sequence analysis, and RNAi).

Overall evaluation The article’s strength is that it provides a platform for further dissemination of information about the topic. Unfortunately, “this article needs additional citations for verification” and the paragraph on gene therapy should be re-written in the author’s own words (8). This underdeveloped article on molecular genetics could be improved by including more content, with relevant pictures, in a thoughtfully organized manner with relevant citations.

My question: How is molecular genetics an investigative approach to heredity? Johannakhb (talk) 16:10, 10 September 2019 (UTC) Johannakhb

Wiki Education assignment: Molecular Genetics
— Assignment last updated by BurgulaNiharika (talk) 23:01, 9 October 2022 (UTC)

Wiki Education assignment: Molecular Genetics
— Assignment last updated by Jellyfish829 (talk) 11:29, 13 December 2023 (UTC)