Talk:N-Nitrosodimethylamine

Lead paragraph & cleanup
I have added a lead paragraph and have removed the 'lead missing' tag. Comments for improvements are welcome. I have reorganized the sections and removed a great deal of repetition.

More edits are probably necessary, preferably from an expert on this chemical. Thanks. Vindemiatrix (talk) 04:32, 14 July 2013 (UTC)

External links modified (February 2018)
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 * Added archive https://web.archive.org/web/20070928004411/http://www.valleywater.org/media/pdf/SFPUC_NDMA_White_Paper.pdf to http://www.valleywater.org/media/pdf/SFPUC_NDMA_White_Paper.pdf

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Properties conflict
The introduction states that NDMA has "little or no taste and odor." The next section states that it has a "characteristic odor and a sweet taste." Recommend that a reputable source correct the information, or have it removed if unknown. — Preceding unsigned comment added by 68.7.1.198 (talk) 05:45, 9 October 2019 (UTC)

NDMA in Zantac
Apparently this compound has been found in Zantac, which is now of course being recalled. Not just a few batches. Every tablet. Contaminated manufacturing process. — Preceding unsigned comment added by 2001:8003:E448:D401:349A:25D9:B6C0:E3B8 (talk) 09:01, 10 October 2019 (UTC)

There is evidence that the apparent presence of NDMA in Zantac is an analytical artifact: i.e., that it is not in fact present - or if so, at a low level - but is formed during the analytical process. Analysis of the material by gas chromatography (GC) involves volatilizing it - often 250C or higher - and the act of heating may cause NDMA to be formed. A liquid chromatography (LC) technique does not require heat; and studies of the same material using both GC and LC procedures have routinely revealed far lower concentrations by LC. I don't have a reference and I don't have time right now so I will try to flesh this out when I do.Cross Reference (talk) 13:51, 9 June 2020 (UTC)

Ranitidine contains an "activated" dimethylamine and nitro group so it could be a decomposition artifact. Sloppy manufacturing possibly but where in the synthesis is the nitrosamine formed? Although ranitidine was sold under many generic and name brands however there was actually only one manufacturer in the world in India. TaylorLeem (talk) 19:08, 21 November 2020 (UTC)

Bias and use of pre 1990s research
Before 1990s classically trained med personell vilified Nitrite. The Nitric Oxide neurotransmitter was discovered in the 1990s, including mammalian enzymes that use dietary Nitrite. Bias is PETA "supersize me" anti-meat bias, otherwise high nitrite levels in Broccoli, root vegetables like carrots, and other foods would be named. And the mechanism for carcinogen is purely theoretical. Chemists who have worked with Diazomethane know that protonated diazomethane, the mythical "methyl diazonium" doesn't exist (has never been shown to exist). The "possible metabolic activation" is contrary to known data about enzymes involved in human nitrite metabolism. TaylorLeem (talk) 19:28, 21 November 2020 (UTC)
 * Thank you! Wikipedia would welcome updated information supported by sources. --Smokefoot (talk) 22:19, 21 November 2020 (UTC)

Sandoz (Novartis) knew of this issue
it's interesting to note that Sandoz, the generic arm of Novartis, contracted synthesis of valsartan (a key component of heart failure med entresto) to discount API manufacturer, China's Zhejiang Huahai Pharmaceutical, in order to save money. Novartis has decades of experience with synthetic routes related to this compound from when it was sold as diovan. They knew of possible ndma contamination. Despite having all the analytical instrumentation known to man, Novartis let this slip by them. For reference the CEO of Novartis' base salary is around 15M. People should also remember this all happened under so called FDA approval and oversight. Steve Brackett (talk) 15:16, 5 May 2024 (UTC)
 * Aren't companies supposed to make decisions " in order to save money"? That is what they are supposed to do. --Smokefoot (talk) 15:46, 5 May 2024 (UTC)