Talk:Nanosponges

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 13 January 2020 and 30 April 2020. Further details are available on the course page. Student editor(s): Lemkec2, Rangas4, Trzasg, Shylaniemann, Clarkb8.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 01:24, 18 January 2022 (UTC)

RPI WikiProject
The intention for this page is to expand on the information already present and to more in depth explain what a nanosponge is, how they work, and their differences in nature versus synthetically created nanosponges. We would like to expand on the applications already mentioned on the page as well as add some, primarily in biological and environmental application. Figures and pictures will be added to further understanding of this topic to readers. This page will be edited by five undergraduate engineering students who are currently enrolled in a BioMaterials class. This project is intended for us to learn more about a topic relating to biology in materials and sharing this with the science community by editing a wikipedia page we feel could benefit with information. We welcome any feedback, advice, or information from other wikipedia members! — Preceding unsigned comment added by Rangas4 (talk • contribs) 01:33, 5 March 2020 (UTC)

4/2/2020 The group has developed ideas for changes and additional sections we would like to add to this page. These are laid out in the outline below but are subject to change as the group continues its ongoing research about the topic. Generally, the group would like to further explain how nanosponges work and what they are outside of medical application and then go more in depth on the numerous applications and ongoing research being done in this area of study.

Description

 * ‘Definition’ and/or basic description
 * History

Mechanisms/Function

 * Cyclodextrin, crosslinked with a 3D network
 * Structure: cyclic glucopyranose oligomers and are synthesized by enzymatic
 * Movement: Prolonged acoustic propulsion (no biofueling)

Natural versus Synthetic
* Coatings (RBC & RBC-PL) * Nanorobots * RBC membranes and platelet membranes
 * Natural: Liposome nanosponge (all-natural)
 * How we are now mimicking them synthetically

Applications
* Drug delivery * Fight antibiotic resistance * Detoxification * Remove metal deposits from wastewater * Chemical sensors * Detection of explosives
 * Medical: Nanosponges coated with RBC for pore-forming toxin neutralization used for
 * Environmental
 * Safety

Current Research

 * Current research is being conducted for use of nanosponges in treating bacterial infections, viral infections, autoimmune diseases, and venoms
 * Different than applications because these are things that are being developed but are not fully developed yet
 * Brain swelling reduced after injury being developed on mice
 * Nanorobots for removal of toxins
 * macrophage biomimetic nanoparticles for management of sepsis

Limitations of research

 * Hard to conduct human studies
 * No human patient studies have been conducted as of 2019
 * Nanoparticles are hard to develop
 * Human and synthetic components increase the complexity of development