Talk:Natural product/Outline2

Classification based on source

 * introduction
 * simple, general utility, historical, but some modern difficulties assigning single sources (e.g., commensal organisms, etc.)
 * explanation that other categorizations create further subsets of simple outline (e.g., marine plants, terrestrial plants)
 * prokaryotic sources
 * bacterial
 * archaeal
 * eukaryotic sources
 * [minimal subsection description: omitted subsections added to categories already in current "Natural sources" section, so later phrases "fungal NP", "marine NP", etc, have meaning]


 * plant
 * fungi
 * animal
 * [minimal section description: brief so to not overwhelm article opening, consolidating repeat-appearing/redundant content (e.g., mult. animal, plant appearances).]

Classification based on biosynthesis/structure
[Note: Development in classification explanations is from organism to molecule, from most easily understood to sophisticated and complicated]
 * acetate pathway → fatty acids and polyketides
 * shikimate pathway → aromatic amino acids and phenylpropanoids
 * mevalonate methyletrythritol phosphate pathways → terpenoids and steroids
 * amino acids → alkaloids

Classification based on function
[note: dichotomy based on Demain and Fang thus far]

Primary metabolites

 * definition, e.g., mainly affecting organism producing, wide species distribution, essential for life, etc.
 * example classes
 * structure – cell membranes (phospholipids), cell walls (peptidoglycans), cytoskeletons (proteins)
 * genetic information – nucleic acids
 * energy – respiratory and photosynthetic enzymes (proteins, cofactors)
 * control
 * first messengers, signaling molecules effecting differentiation, growth factors (proteins, biogenic amines, steroid hormones, auxins, gibberellins, etc.)
 * second messengers (cyclic nucleotides, diacylglycerol, etc.)
 * receptors (proteins)
 * agents integrated into sporulation

Secondary metabolites

 * definition, e;g;, mainly affecting other organisms, narrow species distribution, increased competitiveness rather than survival req., etc.
 * example classes
 * semiochemicals/pheromones
 * agents of symbiosis
 * agents that solubilize and transport nutrients (siderophores, etc.)
 * competitive weapons (toxins, venoms, etc.)
 * unknown function
 * [minimal subsection description: perhaps to include dispensable/narrow species distribution not classified as primary metabolite, w/function otherwise unknown]

Medical uses

 * Traditional medicine and ethnopharmacology
 * Modern pharmacotherapy
 * Marketed drugs
 * Oncology
 * Infectious diseases
 * Other areas
 * Off-market examples

Notable examples
[minimal section description: perhaps to include familiar or societally impactful cases, from red tide to yew needles]
 * microbial antibiotics
 * microbial mycotoxins
 * plant semiochemicals
 * plant colorants

Isolation, purification, and analytical techniques

 * Sources and preparation
 * Crude extracts
 * [minimal subsection description: perhaps to include and wikilink to herbal remedies]


 * Purifications
 * Analyses

Structure and properties

 * Structure determination
 * Property determination

Biotechnology applications

 * screening type assays, incl. HTS
 * individual compound assay
 * pharmacologic evaluation
 * tool compound use
 * toxicology

Commercial production

 * Via harvest
 * Via biotechnology
 * Microbial (incl. fermentation)
 * Plant tissue
 * Semisynthesis
 * Other

Chemical synthesis

 * Microbial transformations
 * Semisynthesis
 * Total synthesis
 * Combinatorial synthesis and biosynthesis

Research and teaching

 * Pharmacognosy
 * Chemical ecology
 * Ethnopharmacology
 * Chemistry
 * [minimal subsection description: perhaps to include remaining aspects of current "Impact on chemistry" section]


 * Other areas
 * [minimal subsection description: perhaps to include phylogenetics, systems biology, and chemoinformatics, as described in Sammuelsson]

Other commercial aspects
[minimal section description: perhaps to include legal definitions and regulations]

History
[minimal section description: perhaps to include parts of current impact on chemistry, but mostly new, from a richly sourced literature, incl. significant societal impacts]