Talk:Neonatal jaundice

Epidemiology and prognosis
Neonatal jaundice -- seems to be happening in 50% or more of infants. What's missing is references that this is in fact a condition that has to be treated as opposed to that it will pass by itself in "7 days" —Preceding unsigned comment added by 76.247.113.170 (talk) 05:28, 19 March 2009 (UTC)

Merge proposal

 * Ok, whereas I think the section in Crigler-Najjar syndrome doesn't have much to add. The neonatal jaundice article has the common and less common differential diagnoses of neonatal jaundice... just needs some clean-up and referencing --like adding the AAP guidelines and explaining how  Tx is based on risk factors and age of the neonate. Nephron  T|C 05:07, 7 August 2006 (UTC)

The cause
I'd really like to be sure, so I have to ask: would somebody please tell, what is the USUAL,ORDINARY cause of neonatal jaundice? Is that the conjugated and non-conjugated bilirubine too? Or just one of them? I'm unable to decide that, because they were both mentioned in that differential diagnosis tree. I know about the red cell's destruction and even the Liver enzymes these are not active enough after birth, but these must point at two: conjugated and non-conjugated bilirubine presence at the blood stream at the same time. But in some articles I read that there's only one inducting factor, so if someone has a decent answer, please post me. Thank you. Olineast 15:33, 14 January 2007 (UTC)

As far as I've read, the usual, ordinary cause is unknown: "presumably a consequence of metabolic and physiological adjustments after birth" to quote the article. However, in severe cases, unseen diseases exacerbating the jaundice may also be present (along side the unknown, normal cause of neonatal jaundice). In the article, these diseases are categorised first as part of a tree, then listed. Some are more common than others, though.

Therefore, in most newborns, jaundice "reflects a normal transitional phenomenon" (emedicine, emphasis added http://www.emedicine.com/ped/topic1061.htm), but generally only in severe cases you might suspect that some other (pathological) cause is present, and you might start looking through the "list". Does that make sense? Lxs602 17:56, 15 February 2007 (UTC)

Ok, I'll edit
I had enough reading (headache). Seriously needed some serious editing actions.

I hope my help is fruitful. AnThRaX Ru (talk) 19:03, 5 August 2008 (UTC)

Too much detail before a summary has been presented
I don't know what other medical articles on wikipedia are like, but when I read the section on treatment, it read "Infants with neonatal jaundice are treated with colored light called phototherapy." - fair enough. But then it immediately went into detailing a bunch of studies "Scientists randomly assigned 66 infants..." rather than a more general discussion of how treatments work - i.e. overhead lights, biliblankets, coloured light etc. I added a sentence mentioning biliblankets to the bottom as they weren't mentioned. --Rjmunro (talk) 09:32, 2 October 2008 (UTC)
 * And it still says this 6 years later. As a non-medical person, I want to know in plain lay language what neonatal jaundice is, what causes it (simply put), what is the health result of having jaundice (short and long term), and basically how it is treated. This article is too complex for the layperson and none of those types of information were simply explained. As you mentioned the study could have been summarized, or, better yet, just left out. 75.173.141.166 (talk) 04:14, 15 January 2015 (UTC)
 * Their are other instances of this mixing of casze studies/research. —Preceding unsigned comment added by 75.38.62.6 (talk) 20:46, 5 February 2009 (UTC)

Lots of work needed
Have added a couple refs to the 2004 AAP guideline. I think much of the article could be based on this. Also can we please use both sets of units that used by the US and that used by the rest of the world. And if anyone has any pull hopefully one day the use with switch.--Doc James (talk) 20:44, 13 December 2008 (UTC)

Obviously, this subject of the research has not been....
done thoroughly http://scholar.google.com/scholar?as_q=breast+milk+jaundice+pregnanediol&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=title&as_sauthors=&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en&lr=&newwindow=1

Please verify my searching from other sources--222.67.212.239 (talk) 09:45, 4 July 2009 (UTC)

this subject http://scholar.google.com/scholar?hl=en&lr=&newwindow=1&q=allintitle%3A+neonatal+jaundice+diet&btnG=Search --222.67.212.239 (talk) 09:55, 4 July 2009 (UTC)

and this subject http://scholar.google.com/scholar?hl=en&lr=&newwindow=1&q=allintitle%3A+hospital+maternal+diet&btnG=Search --222.67.212.239 (talk) 10:09, 4 July 2009 (UTC)

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VJV-4SYDB2C-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=947765989&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f2fa767eaa4169831c45fe385bb7be5c --222.67.212.239 (talk) 10:13, 4 July 2009 (UTC)

Weird....???
http://www3.interscience.wiley.com/journal/121669888/abstract --222.67.212.239 (talk) 10:17, 4 July 2009 (UTC)

http://www.ncbi.nlm.nih.gov/pubmed/18814662

Validations are needed for the above--222.67.218.187 (talk) 10:22, 4 July 2009 (UTC)

This is cool
http://www.ncbi.nlm.nih.gov/pubmed/18540490 --222.67.218.187 (talk) 10:24, 4 July 2009 (UTC)

Diagnosis is not made by "digital pressure"
The introduction contradicts itself. "In newborns jaundice is detected by blanching the skin with digital pressure so that it reveals underlying skin and subcutaneous tissue." Then it goes on to say that judgements based on physical appearance are poor predictors of jaundice.

Diagnosis should be based on total serum bilirubin levels, as measured by (1) transcutaneous devices, (2) photometric methods through plasma, (3) photometric methods through hemolyzed blood, or (4, the gold standard) High Performance Liquid Chromatography.

122.163.91.192 (talk) 12:13, 23 August 2009 (UTC)

I feel a citation is needed for the notoriously innacurate comment, serum testing is certainly going to be more accurate but everywhere I've worked digital pressure has been considered accurate enough to serve as the primary method of diagnosis. Furthermore we have a referenced study showing moderate levels of accuracy so unless someone has a study to support the "notoriously innacurate" claim then it probably shouldn't be there — Preceding unsigned comment added by 117.199.175.17 (talk) 06:14, 27 August 2011 (UTC)

neonatal jaundice is the yellow appearance of the neonate, made by evaluating the underlying skin and subcutaneous tissue for a yellow color. hyperbilirubinemia is elevated serum bilirubin levels. the two are distinctly different because a newborn can appear yellow and yet his bilirubin leve is normal and he is jaundiced (or icteric) yet he is not diagnosed with hyperbilirubinemia and can go home with his family and not be subjected to further testing or phototherapy.--Smithcure (talk) 13:53, 12 January 2012 (UTC)

Doctor Comment: In practice if you look yellow, you get tested - if high - then have the condition - the clinical signs raises the suspicion, but the diagnosis is dependent on the blood test. I'm with the original poster - that it needs change. I also note that on all of the comments on breast-feeding related jaundice noone mentions having a BOTTLED milk as well to maintain hydration. — Preceding unsigned comment added by 110.174.150.180 (talk) 13:48, 19 June 2013 (UTC)

Units
What are the units in umol/l? Doc James (talk · contribs · email) 20:37, 16 October 2009 (UTC)

use convertit.com to convert mg/dL into any format you choose.--Smithcure (talk) 14:02, 12 January 2012 (UTC)

Prevention
What do others think about adding a prevention section? I think it would be appropriate to add it between Diagnosis and Treatment. I was going to say something about the evidence that prebiotics may help prevent neonatal jaundice. Fi Stewart (talk) 12:07, 14 January 2021 (UTC)

Treatment
Because one of the causes of physiologic jaundice is the dehydration in breast fed babies, some attention should be paid to the neonates hydration status. Neonates can be treated with increased fluid intake. The fluid of choice is, of course, mom's breast milk. In the absence of mom's milk, donor milk, formula and even IV fluids can be used to correct physiologic jaundice which is caused in part by dehydration--Smithcure (talk) 14:01, 12 January 2012 (UTC)

I'd like to say this photo-treatment is centuries old in tropical Africa, where newborns have been kept in the early hours of the morning, and late at dusk in the sun to clear the yellow-ness of the infant. — Preceding unsigned comment added by Nyonglema (talk • contribs) 16:22, 21 January 2014 (UTC)

Breast Milk / Failure Jaundice
Needs to be corrected — Preceding unsigned comment added by 74.92.162.238 (talk) 03:26, 5 January 2014 (UTC)

seeking additional articles
"Root causes for late presentation of severe neonatal hyperbilirubinaemia in Egypt," Eastern Mediterranean Health Journal, Volume 18 (2012), issue 8.

---

'Why is kernicterus still a major cause of death and disability in low-income and middle-income countries?,' Arch Dis Child. Olusanya, BO; Ogunlesi, TA; Slusher, Tina M. 2014 Dec;99(12):1117-21. doi: 10.1136/archdischild-2013-305506. Epub 2014 Aug 14. http://www.ncbi.nlm.nih.gov/pubmed/25123403 Abstract "Neonatal jaundice is predominantly a benign condition that affects 60%-80% of newborns worldwide but progresses to potentially harmful severe hyperbilirubinaemia in some. Despite the proven therapeutic benefits of phototherapy for preventing extreme hyperbilirubinaemia, acute bilirubin encephalopathy or kernicterus, several low-income and middle-income countries (LMIC) continue to report high rates of avoidable exchange transfusions, as well as bilirubin-induced mortality and neurodevelopmental disorders. .  .  "

'A global need for affordable neonatal jaundice technologies.' Seminars in Perinatology. Slusher TM, Zipursky A, Bhutani VK. 2011 Jun;35(3):185-91. doi: 10.1053/j.semperi.2011.02.014 http://www.ncbi.nlm.nih.gov/pubmed/21641493 http://www.seminperinat.com/article/S0146-0005(11)00043-7/references


 * posted Cool Nerd (talk) 23:06, 20 April 2015 (UTC)

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Jaudice
Need more info less ads no help AT ALL. 2601:247:C204:EC80:CCF4:5273:9F24:D3C9 (talk) 04:03, 30 December 2021 (UTC)