Talk:Nesidioblastosis

note
Although I've failed miserably to log in, I've altered the links found in the "External links" section so that they work - they required only minor tweaks of the 'remove www' variety. JoBrodie (Diabetes UK) 81.150.194.1 (talk) 10:27, 28 December 2007 (UTC)

I can understand why some would like to scrap this antiquated medical term. Seen in a more contemporary examination, it is probably a cluster of similar syndromes rather than a literary definition of any one disease. If we started over, I think common areas of agreement would be required for an encyclopedic outline, my suggestions; 1. Nesidioblastosis represents beta cell proliferation (AKA Islet Cell Hyperplasia) of the pancreas. 2. Beta cell proliferation allows new and accelerated formation of GLP-1, an Incretin hormone. 3. Beta cell proliferation also allows further expression of another incretin; Glucose dependent Insulinotropic Polypeptide or GIP. 4. Genetic influences may be assayed by measuring Insulin Promoter Factor 1 or PDX-1. The encoding gene for humans is lpf1.

badwordin!
Evidence of physiologic mechanisms purporting that weight loss surgery conveys the ability to induce a more contemporary presentation of nesidioblastosis remains elusive and is of intense interest to diabetes researchers.91.183.159.198 (talk) 18:05, 19 February 2018 (UTC)