Talk:Neurobiological effects of physical exercise/Archive 2

Work in progress
I've decided to focus on this article for GA, so I'm going to recite the vast majority of the article; hopefully I won't have to delete anything, because I don't want to do so. If anyone would like to help improve the article to the WP:MEDRS standard, feel free to do so.  Seppi  333  (Insert 2¢ &#124; Maintained) 06:29, 8 December 2014 (UTC)

This article is my #1 priority now, so I'll add this content fix all the citation issues over the next 1-3 months, depending on how much time I have outside WP.  Seppi  333  (Insert 2¢ &#124; Maintained) 10:47, 4 February 2015 (UTC)

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Antidepressant reviews from Talk:Antidepressant/Archive 2:
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2
Formatted current medical review citations with filled quote parameters: Also cover clinical significance/relation of cognitive control in addiction & ADHD
 * Exercise epigenetics reviews:
 * Increased gray matter volume from aerobic exercise:
 * Measurable improvements in attention do not arise as an acute response to exercise, but as a response to consistent exercise:
 * Exercise and trophic factors: 
 * Exercise - bidirectional interactions with cognitive control/executive function:    (Describe components of cognitive control and corresponding structures in the article. )
 * Organ-specific response to exercise (acute and long-term): 

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Formatted review citations, pending quotes:
 * Exercise/cognition
 * Exercise, older adults, and aging:
 * Exercise - biological mechanisms in health/resilience: 
 * Exercise effects upon stroke recovery and neuroprotection:
 * Exercise effects upon mental disorders:
 * Exercise in child cognition and academic performance:

Effects on receptor ligands
 * Beta-Endorphin
 * Endocannabinoids
 * Exercise endocrinology ( monoamines again )

4

 * Summary ref for citing lead


 * General age-related cognitive decline

Neurodegenerative disorders
 * Alzheimer's disease reviews 


 * Parkinson's disease reviews   (also covered in  )


 * Huntington's disease reviews


 * IGF-1 resistance in all 3 disorders

Notable reviews - mostly from 2015/2016

 * Brain glucose mid- and post-exercise responses during prolonged/endurance exercise
 * Effect of CNS monoamines on central fatigue + body temperature limit during exercise
 * Erickson review from 2015
 * Neurooncology (brain cancer) - entire review on the topic
 * Regional CNS effects and associated mechanisms
 * Supplemental review for writing the monoamines section [NEED TO ADD THIS REVIEW]
 * Clinical guidelines for depression
 * Neurocardiac plasticity of the rostral ventrolateral medulla
 * Cochrane dementia review
 * GDNF - need more reviews on this
 * Effect on the basal ganglia [NEED TO ADD THESE REVIEWS - PARTICULARLY THE SECOND]
 * Astrocytes
 * Effects on cognition in healthy young-middle aged adults
 * Astrocytes
 * Effects on cognition in healthy young-middle aged adults

 Seppi  333  (Insert 2¢) 22:56, 27 July 2016 (UTC)

Sept 2016 study - cognitive effects in healthy young adults

 * - need to watch for a review of this paper.  Seppi  333  (Insert 2¢) 06:56, 9 October 2016 (UTC)

New review
I came across this March 2017 review on the acute effects of exercise on cognition, affect, neurophysiology, and neurochemical/myokine signaling from a "Neuroscience news" story on my facebook news feed. Could probably use the news piece as a laysummary parameter in the citation. It makes some very interesting/notable assertions about the effects of acute exercise on executive functions/cognitive control and cognitive processing speed.

And oh my god, I have so much work to do on updating this article with the MASSIVE deluge of reviews and meta-analyses that have been published since I last worked on it 12 months ago (75 reviews, systematic reviews, and meta-analyses from using very specific filters for relevance). It seems like a lot more researchers have actually taken notice of the fact that aerobic exercise induces both acute and chronic psychostimulant-like effects on cognition and marked neuroplasticity in healthy adults and those with CNS disorders.

A couple of templated review/meta-analysis citations to add soonish:  Seppi  333  (Insert 2¢) 12:54, 16 June 2017 (UTC)
 * Review from above with lay summary (not pubmed indexed) – need to cover the content on myokines (BDNF, IGF-1, VEGF), epigenetic/HDAC inhibitor effects of beta-hydroxybutyrate, monoamines, glutamate, acetylcholine, cortisol, HPA-axis, the PFC, executive functions, memory, information processing speed, and a number of other details. - the transient cognitive effects of acute exercise were added
 * Source they cited about acute exercise-induced PFC-dependent effects on cognitive control in healthy adults
 * Meta-analysis on the effects of exercise on resting peripheral BDNF levels:
 * Meta-analysis on the effects of acute exercise on peripheral BDNF in healthy adults:
 * "At least eighty percent of brain grey matter is modifiable by physical activity: A review study" - there's a lot from this review that could still be added  Seppi  333  (Insert 2¢) 20:11, 6 November 2017 (UTC)

Interesting review (IMO) on gender-dependent differences in motivation to engage in physical exercise
I've only read a few scattered paragraphs of this review; I intend to finish reading it later. I've haven't read most of the material relevant to molecular neurobiology and neuropharmacology (NB: some of that may be worth covering). Out of the parts I read, I came across a few significant excerpts that should be added to/paraphrased in the article:

 Seppi  333  (Insert 2¢) 01:10, 12 August 2017 (UTC)

Look for review that covers this primary source and related research
 Seppi  333  (Insert 2¢) 23:55, 21 December 2017 (UTC)
 * (lay summary: http://neurosciencenews.com/exercise-focus-problem-solving-8223)

2018 review to add

 *  Seppi  333  (Insert 2¢) 01:42, 13 March 2019 (UTC)

Long-term effects needs to be sorted by body components
The section on Long-term effects could be sorted by body segments, ie. brain, skin, muscles etc. It appears that the entire Long-term section is basically about brain development. prokaryotes (talk) 21:27, 6 November 2017 (UTC)


 * Sounds like a reasonable approach; I'll look into doing this when I work on restructuring the article later. Thanks for the feedback.  Seppi  333  (Insert 2¢) 07:12, 9 November 2017 (UTC)
 * There are also way too many references occasionally (overlinkage). prokaryotes (talk) 09:30, 10 November 2017 (UTC)
 * That's sometimes unavoidable when an extremely broad or varied list of medical claims in included in an article.  Seppi  333  (Insert 2¢) 23:37, 10 November 2017 (UTC)
 * I ended up restructuring the long-term effects section based upon topical hierarchy; the neuroplasticity subsection covers structural neuroplasticity and cognitive plasticity while the "mechanism of effects" section covers (or rather, will eventually cover) how repeated skeletal muscle contraction releases myokines into the blood stream, which then circulate to the brain via the cardiovascular system, and bind to receptors located on neurons. Before adding that content though, I need to identify which of the sources I cited that covers how regular exercise leads to repeated activation of neurotrophic signaling pathways through the release of myokines, thereby producing lasting changes to neural structure/function. It's been a while since I worked on this article.  Seppi  333  (Insert 2¢) 20:55, 12 March 2019 (UTC)

Statements in the lead/body about clinical effects
I rewrote almost every sentence in this article in the lead and body sections that do not contain a maintenance banner; I don't exaggerate the conclusions of sources that I cite. However, if you feel that there's an issue with how existing article text is worded in relation to the statements in the sources, it would be best to discuss this at WP:NPOV/Noticeboard instead of argue about it with me here since that will generate external/third-party feedback on this content.

I would prefer not to get into an edit war over this.  Seppi  333  (Insert 2¢) 19:07, 13 May 2018 (UTC)


 * Indeed not. However, the lead should not be supporting statements with 6 (even 10) citations which are repeated in the main text (it looks like OR when all that is needed is a summary and one or two refs - indeed, in uncontested (hm, unmedical) leads, none is the best number). I shan't touch it but it sure looks ott. Chiswick Chap (talk)