Talk:Neurofibromatosis type I/Archive 1

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 January 2020 and 30 April 2020. Further details are available on the course page. Student editor(s): ArushN.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 05:09, 17 January 2022 (UTC)

Incidence
I've read the incidence rate in UK is 1/2500, so it's possible who ever wrote that number is from the UK.

Does anyone have a citation? I see 1/2500 births on wikipedia, but have encountered estimates between 1/3000 and 1/4000 births on NF websites and in printed handbooks. I can expect a range of values (high uncertainty), but there's too large a differenece between 1/2500 and 1/4000, no?
 * Above posted by User:128.151.253.249 19:36, 18 January 2006

I agree - 1/3000-1/3500 is the accepted figure as far as I know (as an NF1 researcher).

This is also listed as the rate on the Neurofibromatosis page.
 * Above posted by User:Aarons@chw.edu.au 09:33, 8 May 2006

However, I have done significant research on Neurofibromatosis as well, and it seems journal articles range from 1/3500 to 1/4500. Though I am comfortable in using 1/3500 since it seems to be the figure used in the most recent medical literature. --Jonisabassist (talk) 03:18, 18 December 2008 (UTC)

If the writer has switched to using numbers instead of rates, I think you'll find it should be "... at least 1 million people in the US ...." 86.181.106.147 (talk) 13:15, 23 January 2017 (UTC)

Disambiguation & protein
"NF1" needs a disambiguation page as it is an abbreviation for both the disease and a causitive protein. Not sure how to construct such a page myself. . . Niels Olson 04:00, 29 August 2006 (UTC)
 * I've put an template linking to NF1 (protein) as listed in OMIM 162200, rather than creating a disambiguation page, as I don't think there are many other uses of NF1, but if there are, a disambig page can easily be created. --apers0n 05:54, 29 August 2006 (UTC)


 * I'm not a big fan of creating links to unmade pages. I'd say start making a page yourself, then add the link.


 * The protein encoded for by the NF1 gene is called "neurofibromin", not "NF1 (protein). Any page on the protein should be named neurofibromin.


 * Neurofibromin is a protein that has proposed to have multiple functions, but it is likely that its Ras-GTPase activity is the most functionally important. A family possessing a point mutation that specifically ablates Ras-GTPase function demostrate all the symptoms of NF1.    Dr Aaron 05:59, 29 August 2006 (UTC)

Review
Pathophysiology of NF1. JFW | T@lk  15:17, 4 October 2006 (UTC)

Might as well be Greek to most of us
I know that genetic diseases are complex stuff, but c'mon guys, this reads like a Med School Textbook. Can't we break it down a little to give us less medically inclined readers some idea about what's going on in this article? Seary6579 12:32, 4 May 2007 (UTC)

Well, there first needs to be a more complete article to then put into "plain English." It's missing a ton of info that other disorders that are 10-20 times less common get spelled out in fine detail. It'll just take time. I'll see what I can do. Artsygeek (talk) 06:02, 28 November 2007 (UTC)

Thanks a million.

Seary6579 (talk) 17:54, 31 December 2007 (UTC)

NF1 is so messed up...
This could happen if your child has NF1, that could happen if your child has NF1, but watch for___ if your child has NF1! My Daughter has it, and we are dealing with it. Just be sure to take them to a Dr. for a full check up at least once a year. It also effects their moods and behavior, there is more to worry about than bumps on their skin, and cafe' au lait spots. —Preceding unsigned comment added by 72.131.114.250 (talk) 04:37, 28 August 2008 (UTC)

This is a Neurofibromatosis type 1 specific page:

Here are a few more formatting issues that must be fixed include- NF1 or NF-1 is an acronym for Neurofibromatosis type 1, it is vital that we are consistent with how this is formatted. This is an NF-1 specific page, why is there a section on NF-2??? —Preceding unsigned comment added by Jonisabassist (talk • contribs) 03:23, 18 December 2008 (UTC)

citation
the citation at the end of the "genetics" section needs to be fixed, and the "citation needed" tag removed. I don't know how to do that. anon 08:49, 14 April 2009 (UTC) —Preceding unsigned comment added by 172.191.197.64 (talk)

gene function
Actually, NF-1 regulates a GAP (GTP-ase activating protein) that regulates RAS by dephosphorylating the GTP which is bound to RAS, thus deactivating the RAS protein. When I can source this, I will try to make it back here to change the article. Mba123 (talk) 02:27, 22 May 2009 (UTC)

cancer
i say that someone should remove "shown to occasionally cause cancer" in the first section. it's malignancy rate is mentioned later in the article. it's like 8%. that's not "Occasional".. that's close to rare. —Preceding unsigned comment added by 66.30.140.5 (talk) 00:57, 27 August 2009 (UTC)

Assessment
This article does not have enough reliable sources to support all of the factual claims in it. While it's not necessary to provide a named reference for every single sentence, it should name at least one reference for each section. WhatamIdoing (talk) 01:34, 21 September 2009 (UTC)

Cafe au lait spots
This article states that NF2 is associated with Cafe au Lait spots, but all the medical texts I can find refer to NF1 being linked to these spots - does this need correcting? —Preceding unsigned comment added by Jjdc3 (talk • contribs) 10:36, 22 April 2010 (UTC)

Diagnostic criteria
The article mentions seven cardinal features, but then has nine dots points underneath. This doesn't make sense. 203.10.55.11 (talk) 01:07, 25 November 2013 (UTC)

Treatment
Someone along the line majorly collapsed the treatment section into a single vague paragraph. I will try to reconstruct. This kind of radical editing should be discussed, not unilateral. Erxnmedia (talk) 13:48, 12 August 2016 (UTC)