Talk:Neuropathy

Neurontin and seizures
Could Neurontin cause seizures?
 * —Preceding unsigned comment added by 69.14.188.159 (talk • contribs) 00:51, 12 April 2005

According to the drug literature from the manufacturer a common side effect is "Clumsiness or unsteadiness; continuous, uncontrolled, back-and-forth and/or rolling eye movements" Also "trembling and shaking" The list goes on. WSNRFN

Q:Neuropathic pain from nonperipheral nervous injuries?
This article says that neuropathy is a disease of the peripheral nervous system. However, I've had a lot of itching from a spinal cord injury, and I was told that this was "neuropathic" itching. Was I misunderstanding what my doctor was saying, or can neuropathic pain and itching come from nonperipheral nervous damage?
 * —Preceding unsigned comment added by Creidieki (talk • contribs) 19:37, 4 July 2005

Woolf CJ. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med. 2004;140(6):441-451. Describes four (4) kinds of pain. They are Nociceptive Pain, Inflammatory/Joint Related Pain, Neuropathic pain, and Non-inflammatory/Non-neuropathic pain. I have personally referred to the fourth type of pain as Central Pain meaning the pain is from an abnormal process in the Central Nervous System (i.e. Normal Peripheral Tissues and Nerves). There are nerves at every level of the spinal cord and there can be peripheral nerve injury at the level of the spinal cord injury which would therefore be a neuropathic pain. This pain should radiate around your Torso (assuming the injury was in the thoracic spinal cord level).
 * —Preceding unsigned comment added by Brianloftus (talk • contribs) 02:02, 5 July 2005

Q: Vitamin supplements that can help?
I've seen a lot of anecdotal evidence (including in my own home) of diabetic neuropathy being successfully treated over a short period with supplements of a component of vitamin B-12 called methylcobalamin. It's the component of B-12 that crosses most easily into the brain and spinal cord. If seems fair to me to discuss non drug-based therapies if they're backed by sufficient evidence, but what would constitute sufficient evidence?
 * —Preceding unsigned comment added by Steverapaport (talk • contribs) 20:50, 21 July 2005

Answer: Sufficient evidence would be clinical trials done using methylcobalamine to treat the nerve damage of neuropathy. Two studies were done.
 * Methylcobalamine Clinical Trials and Studies —Preceding unsigned comment added by WSNRFN (talk • contribs) 00:19, 23 July 2008 (UTC)

German Research and Practice
Research in Germany has shown that high doses of Alpha Lipoic Acid (800mg/day) can slow and in some cases reverse effects of Peripheral Neuropathy. The effects take about 3 months to be felt by the patient. It is common practice in Germany to prescribe Alpha Lipoic Acid (ALA) for Peripheral Neuropathy.
 * —Preceding unsigned comment added by 68.123.10.132 (talk • contribs) 03:30, 30 May 2006

Alpha Lipoic Acid is used in the US for neuropathy as well, this is due to the fact that it is an anti-oxidant and slows down the destruction of the nerve cell. WSNRFN —Preceding unsigned comment added by WSNRFN (talk • contribs) 22:59, 30 July 2008 (UTC)

Neuropathy
Please consider adding the following link for additional information:

Http://www.neuropathy.org

Sincerely, Marc A. Silverstein
 * —Preceding unsigned comment added by Msilverstein47 (talk • contribs) 19:37, 24 August 2006

Coeliac and neuropathy
The current article states that coeliac disease can cause neuropathy, but fails to indicate why (and nor does the coeliac disease article itself). Is it the actual immune disease itself or as a result of this condition causing a malaborption and eventually a vitamin deficiency (I'm guessing B12)?

If it is via a B12 deficiency, then this article should not so describe the treatment as just of coeliac itself (for giving B12 injections would also work), but rather treating any underlying cause for B12 deficiency (whether that be coeliac disease or inadequate dietary consumption) or by giving replacement therapy (in cases of people with absent intrinsic factor to permit absorption).David Ruben Talk 01:09, 13 January 2007 (UTC)

My wife has Coeliac and has peripheral neuropathy/sciatica. We have done lots of research on this subject and the jury is apparently still out. The most credible explanation I have heard (from her doctor, so no citable source) is that the autoimmune response to gluten causes systemic inflammation. My wife also has edema, which is consistent with this hypothesis. Inflammation of the piriformis muscle has been implicated in sciatica - in some people the sciatic nerve passes through the piriformis, and inflammation causes it to constrict this nerve and cause neuropathy and referred pain. Steve carlson 03:26, 27 June 2007 (UTC)

Marijuana
I added a new study by Neurology magazine showing smoked marijuana to be an effective medicine for periphial neuropathy. I included a link to an article by an MD discussing this study, but do not subscribe to neurology, so maybe someone else can dig up a better link for sourcing. —The preceding unsigned comment was added by 71.217.107.203 (talk) 16:55, 1 March 2007 (UTC).

Surgery
I've heard of surgery, specifically the DREZ procedure, as a treatment for neuropathic pain caused by SCI. I have only one reference: |The DREZ procedure:  an update on technique C paul butler 16:14, 11 July 2007 (UTC)

Neuralgia
See also Neuralgia. --Una Smith (talk) 01:05, 30 March 2008 (UTC)

Neuropathy vs Neuropathology
Do these need to be separate articles? Neither even have a link to the other article. Alhead (talk) 17:05, 1 December 2008 (UTC)
 * While these terms are indeed etymologically related, they do in fact deal with distinct subjects, so it would not make sense to merge the two articles. It would no doubt be helpful to readers to have some sort of dab link on each page. Anomalous+0 (talk) 05:44, 12 June 2009 (UTC)
 * I have added a sentence to the Intro of each article addressing this point. Anomalous+0 (talk) 04:20, 13 June 2009 (UTC)

Proposal to combine with Peripheral neuropathy
I've suggested a major rearrangement of the neuropathy articles at Talk:Peripheral_neuropathy. Please let me know your views. Neurotip (talk) 17:48, 14 November 2009 (UTC)

I've merged this article with Peripheral neuropathy and Neuropathic pain, and removed its WPMED tag, as part of a reorganisation of the articles relating to neuropathy. I appreciate that further work is needed, and would welcome help in the form of comments or edits. Please see the recent discussion on the Peripheral neuropathy talk page. Neurotip (talk) 18:24, 22 November 2009 (UTC)