Talk:Neurotoxin

Category talk:Neurotoxins
Please see my discussion on the Category talk:Neurotoxins page. --Chinasaur 01:47, 11 August 2004 (UTC)

Merge
why isn't neurotoxin and neurotoxicity the same article. I have no say in whether they are combined or not, but it seens they are kind of the same. jess523s
 * Disagree- They are two different things.--Super7am 23:32, 25 August 2006 (UTC)
 * Agree - neurotoxic (neurotoxicity) should be fused into this article. Poisonous redirects to poison. It would also create one complete article since the information now is minimal. --Surreal 13:51, 11 January 2006 (UTC)
 * Agree - They are both too similar to merit seperate articles. Just for the record, everyone has an equal say in matters such as this mastodon 22:40, 7 May 2006 (UTC)
 * Agree-Each of these articles are too small as it is, and merging them would create a more comprehensive article. --Kahlfin 19:25, 8 May 2006 (UTC)
 * Agree- These articles need some expansion to be worthwhile - it would be better just to consolidate them into the same one. Gkeeling 20:03, 25 May 2006 (UTC)
 * Disagree The concepts are related, but distinct--neurotoxins certainly cause neurotoxicity, but not all neurotoxicity is a result of the actions of neurotoxins. For example, abnormally high levels of endogenous neurotransmitters can have a neurotoxic effect, or metabolic disorders that cause hypoxia...I'm very busy right now, but I can try to expand these articles in the next week or two. -- Scientizzle 18:41, 15 June 2006 (UTC)
 * Disagree I concur with the previous statement. When I think of neurotoxicity, I see a separate and expansive realm of science involving endogenous factors such as excitotoxicity that in some circumstances may be caused by a neurotoxin but are certainly not exlusive to neurotoxins. Oligodendrocyte 16:22, 7 July 2006 (UTC)
 * Weak Agree - I disagree with the above statement on the grounds of common material. Besides the issue of excitotoxicity and other endogenous factors, it seems like most material appearing in one of the articles would appear in the other. Perhaps neurotoxin should be a section within neurotoxicity.Leon... 07:06, 9 July 2006 (UTC)
 * Agree - The two articles are similar it many respects and the merger would improve the quality of both as neurotoxicity can easily be sen as an aspect of neurotoxins
 * Disagree If accurate, these should be two distinct categories, neurotoxin referring to a compound that causes an (adverse) effect, neurotoxicity refering to the principles and mechanisms of action of such compounds. Thomas
 * DisagreeThey are two different things.Biophys 04:54, 20 January 2007 (UTC)
 * DISAGREEthey are different words so they have diferent words they shouldnt be combined. —The preceding unsigned comment was added by 71.153.170.194 (talk • contribs).

The merge proposal tag was removed today for no consensus. -- Scientizzle 03:06, 26 February 2007 (UTC)

A "toxin" != a poison.
I don't know whether the term "toxin" in english toxicology can be applied to all kinds of poisons; in german toxicology, for instance, "toxin" reffers only to a biogenic (i.e. produced by an organism) poison. It is not correct to label e.g. neurotoxic heavy metals or organophosphates as "neurotoxins", since they are of mineral or synthetic origin. A typical neurotoxin is tetrodotoxin or strychnine, but not lead, mercury or Sarin. Could some english-native-speaking toxicologist clarify, whether it is right to mark all neurotoxic substances as "neurotoxins", please?--84.163.95.165 18:26, 21 March 2007 (UTC)


 * The article on toxins is stating the same, along with mention, that the term "toxin" is generously used by general public, or media as a synonyme to all toxic substances or even toxicity as such. I see the problem, that for non-professionals, the term "toxin" is completely interchangeable with "poison", and many articles on synthetic neurotoxic poisons are describing them as "neurotoxins" (example: Tetramethylenedisulfotetramine, a synthetic condensation product of sulfamide and methanal, which is a potent convulsant), but I think that it would be appropriate to reformulate following part of this article:

"Toxins ingested from the environment are described as exogenous and include gases (such as carbon monoxide), metals (such as mercury), liquids (ethanol) and an endless list of solids. When exogenous toxins are ingested, the effect on neurons is largely dependent on dosage. Thus, ethanol (alcohol) is inebriating in low doses, only producing mild neurotoxicity. Prolonged exposure to "safe" alcohol levels slowly weakens and kills neurons."

and (maybe, with the exception of ethanol, as it can be of biogenic origin) to distinguish them from proper neurotoxins, which are discussed in the rest of the article.

Parallelly, an article dealing with neurotoxic substances should be created, or incorporated into the main article Poison, same goes for haemotoxic, cardiotoxic, cytotoxic and otherwise poisonous compounds. A lot of work, yes, but Wiki should be an encyclopedia...--84.163.109.68 23:10, 22 March 2007 (UTC)

some sources on this question
Hello. There is a book about neurotoxins, which says in preface: "Neurotoxins are toxic substances with selective actions on the nervous system. By definition, toxins are of natural origin, but the term 'neurotoxin' has been widely applied to some synthetic chemicals that act selectively on neurones" `a5b (talk) 23:49, 25 May 2011 (UTC)

Portal
Anytime I see neurotoxin, I read it in GLaDOS's voice. — Preceding unsigned comment added by 96.24.179.52 (talk) 19:11, 16 July 2011 (UTC)

Agreed Try searching it and go to images CodyM2001 (talk) 05:19, 25 April 2014 (UTC)

Some Updates
I have made significant changes to the Neurotoxin article. I am relatively new to the process of editing Wikipedia articles and not sure about the policy of replacing existing material. I believe what I have written to be significantly improved over the existing article and so will be uploading it shortly for people to look at. I know the history function exists so nothing from the past will be deleted. In what I have written there are a few problems of which I am aware:

1) The clostridium tetani image is not linking properly (maybe because it is not in the english language section of wikipedia, I have no idea).

2) Some of my links to other articles are not working properly while the majority seem to work fine, and I am not sure what the problem is.

3) Additionally, when I uploaded what I had written, links to neurotoxin articles in other languages disappeared for some reason.

4) Lastly, my references are not in Wikipedia's preferred format, because I was unable to get it working. Hopefully everything is cited well enough that the article can be changed easily to the preferred format. I will work on this improvement as well in the near future.

I hope that this upload is appreciated, and I apologize in advance if this breaks any Wikipedia rules of which I am not aware.

--Rysin (talk) 14:22, 9 December 2011 (UTC)

File:Clostridium tetani bacteria.jpg Nominated for speedy Deletion

 * I'm not sure why this image got tagged. Anybody know how to fix the problem. I really like this image, and think it would be useful in the article. If it helps, I found the image under the Greek language 'Tetanus' Wikipedia article. This is the direct link to the file: Clostridium Botulinum I believe the file is in the public domain as it says, and should thus not be a problem. Hopefully somebody knows how to fix this. --Rysin (talk) 01:53, 16 December 2011 (UTC)


 * Hi Rysin, and congratulations on the excellent work you have done on this article. This image was not displaying originally because it was available on the Greek Wikipedia only. I uploaded it to the English Wikipedia (mistakenly, since the software inconveniently steered it onto the English Wikipedia when I thought I was uploading to WikiCommons). Anyway, that is why the image started displaying on the article. Now a bot is playing games, as you can see from my reply on the talk page of the image. If it mindlessly deletes the image, we'll just have have another go. --Epipelagic (talk) 03:53, 16 December 2011 (UTC)


 * Hey Epipelagic, thanks and that sounds good hopefully it will work. Also I like what you wrote for anatoxin-a, I changed the title of that section hopefully to be a little more fitting. --Rysin (talk) 13:19, 16 December 2011 (UTC)


 * Well another bot went ahead anyway and summarily removed the image. The system for loading images on Wikipedia seems very dysfunctional. Anyway, when I get time, I'll try loading the image to commons, or you could have a go yourself :) --Epipelagic (talk) 01:40, 17 December 2011 (UTC)


 * It turns out an admin summarily removed the image, and he refuses to discuss the matter. So welcome to Wikipedia. Its a fascinating mixture of the sublime and the abysmal. It definitely helps if you happen to be a saint. Anyway, Commons are helpful, and it seems the image can be uploaded there :) --Epipelagic (talk) 02:32, 18 December 2011 (UTC)

25i-NBOMe and Rutgrere 2012 - publication nowhere to be found?
The alleged citation for 25i-NBOMe's neurotoxicity - Rutgrere 2012 - doesn't seem to exist?

Thoughts? — Preceding unsigned comment added by 24.121.115.108 (talk) 05:47, 23 October 2014 (UTC)

External links modified (February 2018)
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Audience Analysis
This excellent article appears to be addressed mainly to chemists and perhaps environmental scientists. A much larger audience that is not yet addressed consists of people who simply don't want their brains poisoned and who may also want to protect the unusually vulnerable brains of their children, including especially fetuses and infants. I wish I had time to be more constructive, but here are a few lay articles suggestive of what I would include: OOPS! I accidentally deleted most of the suggestions. Stay tuned. Page Notes (talk) 01:51, 2 November 2019 (UTC)

Neurotoxins
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity).[3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue.[5] The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic.[4] Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems.[6] Common examples of neurotoxins include lead,[7] ethanol (drinking alcohol),[8] glutamate,[9] nitric oxide,[10] botulinum toxin (e.g. Botox),[11] tetanus toxin,[12] and tetrodotoxin.[6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. 2409:4063:4E8D:58C2:0:0:AA48:7506 (talk) 16:45, 5 May 2022 (UTC)

Neurotoxins
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity).[3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue.[5] The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic.[4] Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems.[6] Common examples of neurotoxins include lead,[7] ethanol (drinking alcohol),[8] glutamate,[9] nitric oxide,[10] botulinum toxin (e.g. Botox),[11] tetanus toxin,[12] and tetrodotoxin.[6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. 2409:4063:4E8D:58C2:0:0:AA48:7506 (talk) 16:45, 5 May 2022 (UTC)