Talk:Nucleoside

Untitled
I removed information that said that nucleoside triphosphates are the major energy products of living systems' energy pathways (or something to that effect). I believe the correct product is nucleoTIDE triphosphates such as ATP. But I am only a 12th-grade AP Biology student, so I could very well be wrong; please correct me if so.

Fist year Undergraduate in biochemistry states,

NucleoSIDE is NOT a nucleoTIDE Nucleoside are any compounds as guanosine or adenosine that consists of a Purine or Pyrimidine base combined with deoxyribose or ribose and is commonly found in DNA or RNA

The user above me forgot to sign his/her work. I put a horizontal line in order to distinguish mine from theirs. It seems that this article is quite lacking. What is the normal role and function of nucleosides? What are they used for in research and in medicine? Are any available as medications? Aren't nucleosides used in the treatment of AIDS? Plus, don't nucleosides kill cells? I linked to this article from the leukemia article, but it doesn't tell me any more information of use to understanding leukemia treatment options. All I find is a chemical description and overview, just science in a vaccuum, nothing that really relates to anything I am trying to understand.--65.190.103.147 06:27, 18 April 2007 (UTC)

In response to the first unsigned user who states "the correct product is nucleoTIDE triphosphates such as ATP": I believe you are getting your terminology confused. A nucleoside monophosphate (such as adenosine monophosphate), is a nucleotide. In other words, nucleoside monophosphate = nucleotide. ATP stands for adenosine triphosphate, which describes a molecule that is a nucleoside (adenosine, with a pentose sugar bound to an adenine nitrogenous base) bound to three phosphate groups. If ATP were a nucleotide triphosphate, you would have a full nucleotide (with pentose, base, AND one phosphate group) plus three phosphates to equal four phosphate groups, which, to my knowledge, does not exist. Hope this clears up any confusion to those new learners trying to clarify and organize the information/terminology in their heads.

— Preceding unsigned comment added by 75.89.103.110 (talk) 16:20, 4 June 2012 (UTC)

nomenclature exception for 5-Methyluridine?
Why is 5-Methyluridine called that? Why not "thymidine" to keep with the nomenclature for an oxygenated deoxynucleoside? Alternatively, why is deoxythymidine also called thymidine? Cmprince (talk) 18:32, 12 July 2008 (UTC)

What happened to inosine? —Preceding unsigned comment added by 68.53.47.50 (talk) 03:23, 4 September 2008 (UTC)

I was wondering if the nucleotide formed by thymine is 5 methylthymidine instead of 5 methyluridine.....I am taking Biocem I currently but it just seems wrong to me.Correction please. —Preceding unsigned comment added by 155.247.166.31 (talk) 11:17, 28 January 2009 (UTC)

I changed it. 5-Methyluridine is a synonym of tymidine which highlights the slight difference between uracil and thymine. This difference is the reason why DNA doesn't use uracil, but I agree that as long as this is not explained in the article, to talk of 5-methyluridine out of the clear blue sky is only irritating.

http://en.wikipedia.org/wiki/Deamination#Cytosine

91.6.127.95 (talk) 01:46, 28 March 2009 (UTC) MarcoP Berlin

I corrected the thymidine tags. The nucleoside is 5'-methyluridine and the deoxynucloside is thymidine. There does not exist a thymidine nucleoside per se, it is 5'-methyluridine and calling the deoxynucleoside "deoxythymidine" is redundant because thymidine is understood to be the deoxynucleoside. Trimethoxy (talk) 14:55, 9 June 2009 (UTC)

Why does "thionucleosides" redirect here?
Not mentioned or defined in article. 109.157.79.50 (talk) 07:06, 9 January 2015 (UTC)

Assessment comment
Substituted at 01:35, 30 April 2016 (UTC)

Figure, Overview Nucleosides
Is there any reason why Inosine is not included in the figure? It is also mentioned in the introduction.

If not I would add it.