Talk:Paola Sebastiani

Untitled
Paola Sebastiani made an important contribution to the field of genetic epidemiology by building prognostic models that can be used for the dissection of complex traits. The most important result was a model based on a Bayesian network that integrates more than 60 single nucleotide polymorphisms (SNPs) and other biomarkers to compute the risk for stroke in patients with sickle cell anemia. This model was shown to have high sensitivity and specificty and demonstrated, for the first time, how accurate risk prediction models of a complex genetic trait that is modulated by several interacting genes can be built using Bayesian networks.

The importance to the field is in:

1) the model per se that can be used for accuracte prognosis: 2) the introduction of an approach that has been shown to be very powerful in many different domains but had never been used in genetic epidemiology; 3) in showing the strong genetic basis of susceptibility to stroke of sickle cell anemia patients and the potential use for stroke prediction in the general population.

Giotto 2116 (talk) 15:31, 1 February 2009 (UTC)

correction of incomplete text
This page was brought to my attention this afternoon and it is incorrect and incomplete.

The sentence "A controversial paper regarding the genetics of aging with which she was associated was retracted from the journal Science in 2011 due to flawed data.[3][4]" is incomplete and the writer apparently refuses to add the complete story of the paper.

The complete sentence should be: "A controversial paper regarding the genetics of aging with which she was associated was retracted from the journal Science in 2011 due to flawed data.[3][4] The corrected version was published in PLOS One http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029848#pone-0029848-g010, and [several of the] genes found associated with exceptional human longevity were replicated in other studies of centenarians, see references:

http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2012.00808.x/full http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099580#pone-0099580-g001 http://link.springer.com/article/10.1007/s11357-013-9593-0#page-1 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808698/

It is shameful that Wikipedia is used to slander scientists without the opportunity to defend themselves

— Preceding unsigned comment added by Paola sebastiani (talk • contribs)
 * The article (already) appears to contain the requested material. Added by User:Thperls in July 2014. Closing this COI edit request. --82.136.210.153 (talk) 16:44, 15 October 2014 (UTC)