Talk:Paroxysmal cold hemoglobinuria

Ig type
I THINK THIS IS IGM NOT IGG AS STATED — Preceding unsigned comment added by 86.176.181.88 (talk) 11:56, 6 April 2013 (UTC)

1872 description
Many sources mention that in 1872 this was first described as a distinct syndrome, but the original reference seems impossible to find so I can't easily corroborate it! JFW &#124; T@lk  11:42, 6 December 2016 (UTC)

Revision Summary (20180903)
I have revised this topic (paroxysmal cold hemoglobinuria) with updates in the literature. Shanbhag 2015 is a recently published, comprehensive review on this topic.

1. Working definition

2. Epidemiology. Basic info on prevalence and incidence. Male preponderance. Epidemiological transition from chronic syphilitic PCH to acute PCH addressed.

3. Cause and Pathophysiology. Concepts on biphasic IgG anti-p autoantibody, complement-mediated intravascular hemolysis, and potential triggers.

4. Clinical Presentation. Divided into acute and chronic forms.

5. Laboratory Investigations. Highlighted the purposes of labs to confirm the diagnosis and exclude differentials incl. WAIHA and CAD. Donath-Landsteiner test as the diagnostic test.

6. Management and Prognosis. General principles, roles of plasmaphersis, immunosuppression, and immunotherapy.

May I suggest for the future directions,

1. Historic aspects. Article on Julius Donath not available. Literature suggested PCH as one of the earliest autoimmune hemolytic anemia reported, probably corresponding to the comment by previous editors (1872 Description). The discovery of DL antibodies classically related to tryponemal infections.

2. Seroepidemiology. The correlation of Donath-Landsteiner antibody to the development of PCH. Increasing availability of laboratory screening allows early detection.

3. Cause. The list of infectious triggers provided here is not exhaustive.

4. Limitations and modification of DL test. This is well recognized in laboratory practice that the already discoloured serum makes interpretation for complement-mediated hemolysis impossible.

5. Updates in management approach

Thank you

Levi852 (talk) 12:05, 3 September 2018 (UTC)

Merge Donath–Landsteiner hemolytic anemia into paroxysmal cold hemoglobinuria
These are classified as the same disease according to these sources: According to Google ngram, paroxysmal cold hemoglobinuria is the most common name. Mikael Häggström (talk) 22:07, 1 May 2023 (UTC)
 * Basit Momin, Majed Abdul; Aluri, Anamika1; Bhaskar, P. M. Bala2. Donath-Landsteiner Hemolytic Anemia with Erythrophagocytosis and Platelet Phagocytosis in Peripheral Smear: Rare Findings. Medical Journal of Dr. D.Y. Patil Vidyapeeth 15(4):p 601-604, Jul–Aug 2022. | DOI: 10.4103/mjdrdypu.mjdrdypu_373_20
 * This topic last updated: Apr 05, 2023.
 * ✅ Klbrain (talk) 18:14, 16 November 2023 (UTC)