Talk:Peyronie's disease

Reads like an advert
This article reeks of the worst kind of advertising: adverts for "male enhancement". I am speaking mostly about the section on treatments. Lines like "Due to the very intrusive nature of penile curvature correction surgery, and the arguably scarce [sic] results that it provides[...]" Clearly break WP:NPOV and WP:NOADS. In fact, excluding citation 23, citations 20-24 are taken directly from websites that sell these types of devices. I'll try to do some cleanup, but bare in mind I am a new user. Lebowbowbowski (talk) 02:01, 1 March 2011 (UTC)
 * Your work got reverted maybe? I went back in and cleaned it up.  The sources have made it to publication but links to those studies need paid accounts to see them so the one link is still connected to their sales site.  I made it clear that no complete reversals of the condition is possible and usually minor curvature improvements are effected.  The sources were misquoted and I corrected this and I removed the unsourced attacks against surgery.  Surgery can cause shortening but one of the techniques I saw in the source has postop patients using vacuum devices to gently stretch and avoid this. This page needs watching for the extender sales people are trying to pad it.  97.85.168.22 (talk) 14:09, 28 August 2012 (UTC)

Verapamil
The article states that calcium channel blockers can cause this disease; it also states that Verapamil is a possible treatment. Verapamil is a calcium channel blocker. Can someone please explain how/why a drug that causes the disease would also be used to treat it? This is very confusing. Thank you. 64.185.130.216 (talk) 16:44, 2 September 2012 (UTC)
 * Intralesional verapamil is alleged to work and there is a paper out on this. http://www.sciencedirect.com/science/article/pii/S0090429597007000  They have gotten small effects in small groups.  There is no medical consensus that it works...as many trials of verapamil have failed and led to no published papers.  On SITE the drug acts differently than taken orally. Here's what they say "Calcium channel blockers have been shown in vitro and in vivo to inhibit secretion and synthesis of extracellular matrix, including collagen, glycosaminoglycans, and fibronectin, as well as causing increased collagenase and anti transforming growth factor-beta activity. Calcium antagonists, including verapamil, are effective in stimulating the remodeling and degradation of extracellular matrix in tissue by altering the metabolic pathways of fibroblasts. Recently, a pilot study (1994) showed preliminary promising results in treating plaque caused by Peyronie’s disease. This randomized single-blind placebo-based study (1994 to 1996) was undertaken to confirm the hypothesis." Angelatomato (talk) 12:51, 31 December 2012 (UTC)

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please add link to https://commons.wikimedia.org/wiki/Category:Peyronie%27s_disease
please add link to https://commons.wikimedia.org/wiki/Category:Peyronie%27s_disease 2A02:8071:8C1:6000:F03B:951F:166D:1D58 (talk) 18:59, 27 April 2022 (UTC)