Talk:Philip Needleman

references for different research areas where he made a large impact
Below are a few articles from each area of contributions--these are mostly from (leading) academic journals but also includes citations from national newspapers.

PROSTAGLANDINS

Nishikawa K, Morrison A, Needleman P. Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney. J Clin Invest. 1977 Jun;59(6):1143-50. doi: 10.1172/JCI108738. PMID: 864006; PMCID: PMC372327.

Morrison AR, Nishikawa K, Needleman P. Unmasking of thromboxane A2 synthesis by ureteral obstruction in the rabbit kidney. Nature. 1977 May 19;267(5608):259-60. doi: 10.1038/267259a0. PMID: 865616.

Morrison AR, Moritz H, Needleman P. Mechanism of enhanced renal prostaglandin biosynthesis in ureter obstruction. Role of de novo protein synthesis. J Biol Chem. 1978 Nov 25;253(22):8210-2. PMID: 711747.

Okegawa T, DeSchryver-Kecskemeti K, Needleman P. Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. J Pharmacol Exp Ther. 1983 Apr;225(1):213-8. PMID: 6403696.

Okegawa T, Jonas PE, DeSchryver K, Kawasaki A, Needleman P. Metabolic and cellular alterations underlying the exaggerated renal prostaglandin and thromboxane synthesis in ureter obstruction in rabbits. Inflammatory response involving fibroblasts and mononuclear cells. J Clin Invest. 1983 Jan;71(1):81-90. doi: 10.1172/jci110754. PMID: 6848562; PMCID: PMC436840.

ATRIOPEPTINS

Needleman P, Greenwald JE. Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med. 1986 Mar 27;314(13):828-34. doi: 10.1056/NEJM198603273141306. PMID: 2936957.

Currie MG, Geller DM, Cole BR, Siegel NR, Fok KF, Adams SP, Eubanks SR, Galluppi GR, Needleman P. Purification and sequence analysis of bioactive atrial peptides (atriopeptins). Science. 1984 Jan 6;223(4631):67-9. doi: 10.1126/science.6419347. PMID: 6419347.

Manning PT, Schwartz D, Katsube NC, Holmberg SW, Needleman P. Vasopressin-stimulated release of atriopeptin: endocrine antagonists in fluid homeostasis. Science. 1985 Jul 26;229(4711):395-7. doi: 10.1126/science.2990050. PMID: 2990050.

Schwartz D, Geller DM, Manning PT, Siegel NR, Fok KF, Smith CE, Needleman P. Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide. Science. 1985 Jul 26;229(4711):397-400. doi: 10.1126/science.3160114. PMID: 3160114.

Wide effects of heart hormone are found. New York Times, Science Times, October 21, 1986

ANGIOTENSION II

Needleman P, Kulkarni PS, Raz A. Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes. Science. 1977 Jan 28;195(4276):409-12. doi: 10.1126/science.831285. PMID: 831285.

Raz A, Isakson PC, Minkes MS, Needleman P. Characterization of a novel metabolic pathway of arachidonate in coronary arteries which generates a potent endogenous coronary vasodilator. J Biol Chem. 1977 Feb 10;252(3):1123-6. PMID: 838699.

Marshall GR, Vine W, Needlemann P. A specific competitive inhibitor of angiotensin II. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1624-30. doi: 10.1073/pnas.67.3.1624. PMID: 4322025; PMCID: PMC283399.

Needleman P, Minkes M, Raz A. Thromboxanes: selective biosynthesis and distinct biological properties. Science. 1976 Jul 9;193(4248):163-5. doi: 10.1126/science.945611. PMID: 945611.

CELEBREX CITES

Merlie JP, Fagan D, Mudd J, Needleman P. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J Biol Chem. 1988 Mar 15;263(8):3550-3. PMID: 2831188.

Raz A, Wyche A, Needleman P. Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1657-61. doi: 10.1073/pnas.86.5.1657. PMID: 2493647; PMCID: PMC286758.

Masferrer JL, Zweifel BS, Seibert K, Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest. 1990 Oct;86(4):1375-9. doi: 10.1172/JCI114850. PMID: 2120289; PMCID: PMC296874.

Needleman P, Isakson PC. The discovery and function of COX-2. J Rheumatol Suppl. 1997 Jul;49:6-8. PMID: 9249644.

P. Needleman, and P.C. Isakson. 1998. "Selective Inhibition of Cyclooxygenase 2" Science and Medicine 5, 26-35. '

Searle’s Arthritis Drug Relieves Pain, Apparently without Causing Ulcers, Wall St. J., 10-15-96, Robert Length

WSJ, Once a floundering business, Searle is now pharmaceutical plum, 6-2-1998, Thomas Burton

ORGANIC NITRATES

Needleman P, Blehm DJ, Rotskoff KS. Relationship between glutathione-dependent dentration and the vasodilator effectiveness of organic nitrates. J Pharmacol Exp Ther. 1969 Feb;165(2):286-8. PMID: 4973991.

Needleman P, Lang S, Johnson EM Jr. Organic nitrates: relationship between biotransformation and rational angina pectoris therapy. J Pharmacol Exp Ther. 1972 Jun;181(3):489-97. PMID: 4624401.

Philip Needleman, John C. Krantz,

The biotransformation of nitroglycerin,

Biochemical Pharmacology,

Volume 14, Issue 8,

1965,

Pages 1225-1230,

ISSN 0006-2952,

https://doi.org/10.1016/0006-2952(65)90299-6.

( https://www.sciencedirect.com/science/article/pii/0006295265902996 )

BooK:  Organic Nitrates, P. Needleman (ed.). Springer-Verlag, 1975.

Heart researcher finds ingested nitrates may be useless as long-term pain killer.

WSJ, 4-18-72 Lawrence Needleman (talk) 12:02, 15 June 2024 (UTC)


 * For science researchers, a common approach would be to create a section titled Selected publications, in which perhaps five journal articles could be listed. I recommend reviews and human work over in vitro or animal. David notMD (talk) 01:27, 16 June 2024 (UTC)
 * thanks! Lawrence Needleman (talk) 12:19, 18 June 2024 (UTC)